関: pramoxine、pramoxine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/09 00:09:26」(JST)

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Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic used as an antipruritic.

The popular itch creams Gold Bond and Calamine Lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble, and therefore more easily absorbed into the skin.

Usage

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches.^[1] Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.

Notes

^ http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682429.html

English Journal

[A case of prostate cancer presenting as extensive abdominal metastasis].

Shirono Y, Hanyu S, Ikarashi T.Author information The Department of Urology, Kariwagun General Hospital.AbstractA 73-year-old man was admitted to our hospital with a chief complaint of hematemesis. Two years before admission, adenocarcinoma of unknown origin was diagnosed. Since then, the patient had been taking TS-1 (pramoxine hydrochloride) medication, which caused gastroduodenal mucosal damage. A large abdominal tumor and elevated prostate specific antigen (PSA) level of 13,190 ng/ml, caused by this damage, were detected. Extensive abdominal metastasis of prostate cancer was diagnosed and combined androgen blockade was initiated. After 3 months, the PSA level decreased to 4.4 ng/ml and the abdominal tumor shrunk significantly. Physicians should keep in mind prostate cancer in the differential diagnosis of unexplained adenocarcinoma.
Hinyokika kiyo. Acta urologica Japonica.Hinyokika Kiyo.2013 Jan;59(1):51-5.
A 73-year-old man was admitted to our hospital with a chief complaint of hematemesis. Two years before admission, adenocarcinoma of unknown origin was diagnosed. Since then, the patient had been taking TS-1 (pramoxine hydrochloride) medication, which caused gastroduodenal mucosal damage. A large abd
PMID 23412126

Ion-Selective Electrodes for the Potentiometric Determination of Pramoxine HCl Using Different Ionophores.

Ramadan NK, Merey HA.AbstractFour novel pramoxine HCl (PAM) selective electrodes were investigated with 2-nitrophenyl octylether as a plasticiser in a polymeric matrix of polyvinyl chloride (PVC). Sensor 1 was fabricated using sodium-tetraphenylborate (TPB) as an anionic exchanger without incorporation of an ionophore. Sensor 2 used 2-hydroxy propyl -cyclodextrin as an ionophore, while sensors 3 and 4 were constructed using 4-sulfocalix-6-arene and 4-sulfocalix-8-arene respectively as ionophores. Linear responses of PAM within the concentration ranges of 1.0 × 10-4 to 1.0 × 10-2 mol L-1 and 1.0 × 10-5 to 1.0 × 10-2 mol L-1 were obtained using sensors 1 and 2, respectively and 1.0 × 10-6 to 1.0 × 10-2 mol L-1 were obtained using sensors 3 and 4. Nernstian slopes of 50.4 ± 0.6, 54.3 ± 0.8, 56.3 ± 0.3 and 59.1 ± 0.5 mV/decade over the pH range of 3.0-6.0 were observed. The selectivity coefficients of the developed sensors indicated excellent selectivity for PAM. The utility of 2-hydroxy- propylcyclodextrin (2HP-β-CD) and 4-sulfocalix [6,8] arene (SC 6, 8) as ionophores had a significant influence on increasing the membrane sensitivity and selectivity of sensors 2, 3 and 4 compared to sensor 1. The proposed sensors displayed useful analytical characteristics for the determination of PAM in bulk powder, pharmaceutical formulation, and in biological fluid. Validation of the method showed the suitability of the proposed electrodes for the use in the quality control assessment of the drug. Furthermore, statistical comparison between the results obtained by the proposed method and the official method of the drug was performed and no significant difference was found.
Acta chimica Slovenica.Acta Chim Slov.2012 Dec;59(4):870-8.
Four novel pramoxine HCl (PAM) selective electrodes were investigated with 2-nitrophenyl octylether as a plasticiser in a polymeric matrix of polyvinyl chloride (PVC). Sensor 1 was fabricated using sodium-tetraphenylborate (TPB) as an anionic exchanger without incorporation of an ionophore. Sensor 2
PMID 24061370

Local cooling for relieving pain from perineal trauma sustained during childbirth.

East CE, Begg L, Henshall NE, Marchant PR, Wallace K.Author information Department ofObstetrics and Gynaecology, University ofMelbourne, Pregnancy Research Centre,Department of PerinatalMedicine,RoyalWomen’sHospital, Parkville, Australia. eastc@unimelb.edu.au.AbstractBACKGROUND: Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2012 May 16;5:CD006304. doi: 10.1002/14651858.CD006304.pub3.
BACKGROUND: Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments.OBJECTIVES: To evaluate the effectiveness and side effects of localised cooling tre
PMID 22592710

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★リンクテーブル★

リンク元	「プラモカイン」「pramoxine」

「プラモカイン」

Pramocaine
Systematic (IUPAC) name
	4-[3-(4-butoxyphenoxy)propyl]morpholine
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682429
Pregnancy cat.	?
Legal status	OTC (CA) POM (UK) ℞-only (US) (with hydrocortisone)
Routes	Topical, rectal
Identifiers
CAS number	140-65-8 637-58-1
ATC code	D04AB07 C05AD07
PubChem	CID 4886
ChemSpider	4717
UNII	068X84E056
ChEBI	CHEBI:8357
ChEMBL	CHEMBL1198
Chemical data
Formula	C17H27NO3
Mol. mass	293.401 g/mol
	SMILES O(c2ccc(OCCCN1CCOCC1)cc2)CCCC;
	InChI InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3 ; Key:DQKXQSGTHWVTAD-UHFFFAOYSA-N ;
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