posttraumatic stress disorder

出典: meddic

外傷後ストレス障害, PTSD

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/04 14:22:54」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/07/25 13:43:10」(JST)

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英文文献

  • The α1 adrenoceptor antagonist prazosin enhances sleep continuity in fear-conditioned Wistar-Kyoto rats.
  • Laitman BM1, Gajewski ND2, Mann GL2, Kubin L2, Morrison AR2, Ross RJ3.Author information 1Department of Animal Biology, School of Veterinary Medicine, Philadelphia, PA, United States. Electronic address: benjamin.laitman@mssm.edu.2Department of Animal Biology, School of Veterinary Medicine, Philadelphia, PA, United States.3Veterans Affairs Medical Center, Philadelphia, PA, United States; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; Department of Animal Biology, School of Veterinary Medicine, Philadelphia, PA, United States.AbstractFragmentation of rapid eye movement sleep (REMS) is well described in individuals with posttraumatic stress disorder (PTSD) and likely has significant functional consequences. Fear-conditioned rodents may offer an attractive model of the changes in sleep that characterize PTSD. Following fear conditioning (FC), Wistar-Kyoto (WKY) rats, a strain known to be particularly stress-sensitive, have increased REMS fragmentation that can be quantified as a shift in the distribution of REMS episodes towards the more frequent occurrence of sequential REMS (inter-REMS episode interval≤3 min) vs. single REMS (interval>3 min). The α1 adrenoceptor antagonist prazosin has demonstrated efficacy in normalizing sleep in PTSD. To determine the utility of fear-conditioned WKY rats as a model of sleep disturbances typical of PTSD and as a platform for the development of new treatments, we tested the hypothesis that prazosin would reduce REMS fragmentation in fear-conditioned WKY rats. Sleep parameters and freezing (a standard measure of anxiety in rodents) were quantified at baseline and on Days 1, 7, and 14 following FC, with either prazosin (0.01mg/kg, i.p.) or vehicle injections administered prior to testing in a between-group design. Fear conditioning was achieved by pairing tones with a mild electric foot shock (1.0mA, 0.5s). One, 7, and 14 days following FC, prazosin or vehicle was injected, the tone was presented, freezing was measured, and then sleep was recorded from 11 AM to 3 PM. WKY rats given prazosin, compared to those given vehicle, had a lower amount of seq-REMS relative to total REMS time 14 days after FC. They also had a shorter non-REMS latency and fewer non-REMS arousals at baseline and on Days 1 and 7 after FC. Thus, in FC rats, prazosin reduced both REMS fragmentation and non-REMS discontinuity.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Mar 3;49:7-15. doi: 10.1016/j.pnpbp.2013.11.004. Epub 2013 Nov 15.
  • Fragmentation of rapid eye movement sleep (REMS) is well described in individuals with posttraumatic stress disorder (PTSD) and likely has significant functional consequences. Fear-conditioned rodents may offer an attractive model of the changes in sleep that characterize PTSD. Following fear condit
  • PMID 24246572
  • Contextualisation in the revised dual representation theory of PTSD: A response to Pearson and colleagues.
  • Brewin CR, Burgess N.Author information University College London, UK. Electronic address: c.brewin@ucl.ac.uk.AbstractThree recent studies (Pearson, 2012; Pearson, Ross, & Webster, 2012) purported to test the revised dual representation theory of posttraumatic stress disorder (Brewin, Gregory, Lipton, & Burgess, 2010) by manipulating the amount of additional information accompanying traumatic stimulus materials and assessing the effect on subsequent intrusive memories. Here we point out that these studies involve a misunderstanding of the meaning of "contextual" within the theory, such that the manipulation would be unlikely to have had the intended effect and the results are ambiguous with respect to the theory. Past and future experimental tests of the theory are discussed.
  • Journal of behavior therapy and experimental psychiatry.J Behav Ther Exp Psychiatry.2014 Mar;45(1):217-9. doi: 10.1016/j.jbtep.2013.07.011. Epub 2013 Aug 6.
  • Three recent studies (Pearson, 2012; Pearson, Ross, & Webster, 2012) purported to test the revised dual representation theory of posttraumatic stress disorder (Brewin, Gregory, Lipton, & Burgess, 2010) by manipulating the amount of additional information accompanying traumatic stimulus mater
  • PMID 24041427
  • Substance use disorders and PTSD: An exploratory study of treatment preferences among military veterans.
  • Back SE, Killeen TK, Teer AP, Hartwell EE, Federline A, Beylotte F, Cox E.Author information Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC, United States; Ralph H. Johnson Veterans Affairs Medical Center, 109 Bee Street, Charleston, SC, United States. Electronic address: backs@musc.edu.AbstractBACKGROUND: Substance use disorders (SUDs) and Post Traumatic Stress Disorder (PTSD) frequently co-occur among Veterans and are associated with poor treatment outcomes. Historically, treatments for SUDs and PTSD have been delivered sequentially and independently. More recently, however, integrated treatments have shown promise. This study investigated Veterans' perceptions of the interrelationship between SUDs and PTSD, as well as treatment preferences.
  • Addictive behaviors.Addict Behav.2014 Feb;39(2):369-73. doi: 10.1016/j.addbeh.2013.09.017. Epub 2013 Oct 5.
  • BACKGROUND: Substance use disorders (SUDs) and Post Traumatic Stress Disorder (PTSD) frequently co-occur among Veterans and are associated with poor treatment outcomes. Historically, treatments for SUDs and PTSD have been delivered sequentially and independently. More recently, however, integrated t
  • PMID 24199930

和文文献

  • PTSDの予防と緩和における魚油の可能性(シンポジウム:精神栄養・行動医学 : 抑うつや不安の予防・治療における新しい可能性,2013年,第54回日本心身医学会総会ならびに学術講演会(横浜))
  • 野口 普子,西 大輔,松岡 豊
  • 心身医学 54(9), 856-860, 2014-09-01
  • 心的外傷後ストレス障害(PTSD)は,恐怖記憶の過剰な固定化と馴化・消去学習が進まない病態として考えられる精神疾患である.動物実験から得られた海馬における恐怖記憶のメカニズムに関する知見から,海馬の神経新生を適切に制御することができれば,恐怖記憶が保存される脳領域をコントロールできる可能性が報告された(Kitamuraら,2009).また,ラットにω3系脂肪酸を投与すると,海馬における神経新生を促 …
  • NAID 110009841121
  • Brain Science(120)PTSDをめぐる最近の動向 : 中・長期ケアの視点から
  • PTSDと睡眠障害 (特集 さまざまな精神・神経疾患に伴う併存する睡眠障害(治療法を含めて))

関連リンク

What is Post-traumatic Stress Disorder (PTSD)? When in danger, it’s natural to feel afraid. This fear triggers many split-second changes in the body to prepare to defend against the danger or to avoid it. This “fight-or-flight” response is ...
Post Traumatic Stress Disorder (sometimes written 'Post-traumatic Stress Disorder', 'Posttraumatic Stress Disorder', or simply 'PTSD') is an anxiety disorder which develops in some individuals who have been exposed to a traumatic ...

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★リンクテーブル★
リンク元外傷後ストレス障害」「外傷後ストレス症」「PTSD
関連記事stress」「disorder」「stressed」「disordered

外傷後ストレス障害」

  [★]

posttraumatic stress disorder, posttraumatic stress disorder, post-traumatic stress disorder, PTSD
心的外傷後ストレス障害心的外傷性ストレス障害
  • 精神系 090424 IV
  急性ストレス反応 外傷後ストレス障害 適応障害
ストレス強度
個体要因
発現時間 1hr以内 遅発性
(数W~数M)
1M以内
症状 幻覚、抑うつ、不安、激怒、絶望、葛藤、引きこもり 再体験、回避、精神麻痺、過覚醒 抑うつ、不安、行為障害
経過 48hr以内に沈静化 慢性、動揺性の経過
1Y後に50%が回復
1M以内、遅くとも5M以内

国試



外傷後ストレス症」

  [★]

posttraumatic stress disorder
心的外傷後ストレス症候群外傷後ストレス障害


PTSD」

  [★] 外傷後ストレス障害, post-traumatic stress disorder, posttraumatic stress disorder


stress」

  [★]

  • n.
  • v.
  • 強調する
accentaccentuateaccentuationemphasisemphasizehighlightpower pointstraintonetonusunderscore


WordNet   license wordnet

「to stress, single out as important; "Dr. Jones emphasizes exercise in addition to a change in diet"」
emphasize, emphasise, punctuate, accent, accentuate

WordNet   license wordnet

「special emphasis attached to something; "the stress was more on accuracy than on speed"」
focus

WordNet   license wordnet

「difficulty that causes worry or emotional tension; "she endured the stresses and strains of life"; "he presided over the economy during the period of the greatest stress and danger"- R.J.Samuelson」
strain

WordNet   license wordnet

「(physics) force that produces strain on a physical body; "the intensity of stress is expressed in units of force divided by units of area"」

WordNet   license wordnet

「the relative prominence of a syllable or musical note (especially with regard to stress or pitch); "he put the stress on the wrong syllable"」
emphasis, accent

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉(精神的・感情的な)『緊張』,ストレス / 〈U〉(…に対する)『強調』,力説《+on+名》 / 〈C〉〈U〉『強勢』,アクセント / 〈U〉(一般に)『圧迫』,圧力 / …‘を'『強調する』,力説する / 〈音節・語〉‘に'強勢(アクセント)を置く / 《まれ》(に)圧力をかける」

WordNet   license wordnet

「put stress on; utter with an accent; "In Farsi, you accent the last syllable of each word"」
accent, accentuate


disorder」

  [★]

  • 障害:個人的苦痛や機能の障害があるので「疾病」とは言えるものの、その背景にある臓器障害がもう一つはっきりしない場合に用いられる。(PSY.9)
  • n.
  • an untidy state; a lack of order or organization (⇔order)
  • violent behaviour of large groups of people
  • an illness that cause a part of the body to stop functioning correctly
  • 注意
disease <> illness <> disorder
  • vt.
  • 乱す、乱雑にする。(人)の(心身の)調子を狂わせる。
  • vi.

WordNet   license wordnet

「bring disorder to」
disarray

WordNet   license wordnet

「a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time"」
upset

WordNet   license wordnet

「a disturbance of the peace or of public order」

PrepTutorEJDIC   license prepejdic

「〈U〉『無秩序』,混乱,乱雑(confusion) / 《しばしば複数形で》(社会的・政治的な)粉争,騒動 / 〈C〉(肉体的・精神的な)不調,異常,障害 / …‘の'秩序を乱す / 〈心身〉‘に'異常を起こさせる」


stressed」

  [★]

WordNet   license wordnet

「suffering severe physical strain or distress; "he dropped out of the race, clearly distressed and having difficulty breathing"」
distressed

WordNet   license wordnet

「bearing a stress or accent; "an iambic foot consists of an unstressed syllable followed by a stressed syllable as in `delay''"」
accented


disordered」

  [★]

WordNet   license wordnet

「not arranged in order」
unordered




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