plasminogen activators

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/27 11:15:57」(JST)

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  • Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1.
  • Lemaire R1, Burwell T2, Sun H2, Delaney T2, Bakken J2, Cheng L2, Rebelatto MC2, Czapiga M2, de-Mendez I3, Coyle AJ2, Herbst R2, Lafyatis R4, Connor J2.
  • Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2016 Feb;68(2):473-83. doi: 10.1002/art.39443.
  • OBJECTIVE: Systemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation-fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI-1) is the major inhibitor of profibrinolytic plasminogen activators (PAs). This study
  • PMID 26414805
  • Tissue and urokinase plasminogen activators instigate the degeneration of retinal ganglion cells in a mouse model of glaucoma.
  • Chintala SK1.
  • Experimental eye research.Exp Eye Res.2016 Feb;143:17-27. doi: 10.1016/j.exer.2015.10.003. Epub 2015 Oct 22.
  • Elevated intraocular pressure (IOP) promotes the degeneration of retinal ganglion cells (RGCs) during the progression of Primary Open-Angle Glaucoma (POAG). However, the molecular mechanisms underpinning IOP-mediated degeneration of RGCs remain unclear. Therefore, by employing a mouse model of POAG,
  • PMID 26474495
  • Distinct encounter complexes of PAI-1 with plasminogen activators and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop.
  • Qureshi T1, Goswami S1, McClintock CS1, Ramsey MT1, Peterson CB1.
  • Protein science : a publication of the Protein Society.Protein Sci.2016 Feb;25(2):499-510. doi: 10.1002/pro.2841. Epub 2015 Dec 2.
  • Plasminogen activator inhibitor-1 (PAI-1) is a biologically important serine protease inhibitor (serpin) that, when overexpressed, is associated with a high risk for cardiovascular disease and cancer metastasis. Several of its ligands, including vitronectin, tissue-type and urokinase-type plasminoge
  • PMID 26548921


  • ヒト胎盤形成におけるプロテアーゼ系の寄与
  • 血栓溶解機構とその制御 (特集 血栓・塞栓症 : 治療・予防の最新動向) -- (基礎研究の進歩)
  • Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid.


1. Adv Cancer Res. 1985;44:139-266. Plasminogen activators, tissue degradation, and cancer. Danø K, Andreasen PA, Grøndahl-Hansen J, Kristensen P, Nielsen LS, Skriver L. PMID: 2930999 [PubMed - indexed for MEDLINE]
Rijken DC (1988). "Relationships between structure and function of tissue-type plasminogen activator". Klin. Wochenschr. 66 Suppl 12: 33–9. PMID 3126346. Bode W, Renatus M (1997). "Tissue-type plasminogen activator: variants ...






plasminogen activator, PA
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  • n.

WordNet   license wordnet

「(biology) any agency bringing about activation; a molecule that increases the activity of an enzyme or a protein that increases the production of a gene product in DNA transcription」


  [★] プラスミノゲン

WordNet   license wordnet

「an inactive form of plasmin that occurs in plasma and is converted to plasmin by organic solvents」