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- 1. 細胞遺伝学的および分子遺伝学的診断ツール cytogenetic and molecular genetic diagnostic tools
- 2. C型肝炎ウイルス感染に対する試験的治療 investigational therapies for hepatitis c virus infection
- 3. クローン病の内科的マネージメントにおける試験研究治療 investigational therapies in the medical management of crohns disease
- 4. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency
- 5. ポリメラーゼ連鎖反応(PCR) polymerase chain reaction
English Journal
- Formation of the N(2)-acetyl-2,6-diaminopurine oligonucleotide impurity caused by acetyl capping.
- Rodriguez AA1, Cedillo I2, Mowery BP2, Gaus HJ2, Krishnamoorthy SS2, McPherson AK2.
- Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Aug 1;24(15):3243-6. doi: 10.1016/j.bmcl.2014.06.025. Epub 2014 Jun 18.
- The acetyl 'capping' reaction routinely employed during phosphorothioate oligonucleotide synthesis has been implicated in the formation of an impurity species with a mass 41amu greater than the expected oligonucleotide molecule. The impurity has been found to arise by conversion of a protected guani
- PMID 24980055
- Importance of rigorous in vitro evaluation of prospective cell binding aptamers.
- Avci-Adali M1, Mludek K, Perle N, Stoll H, Schlensak C, Wendel HP.
- Nucleic acid therapeutics.Nucleic Acid Ther.2014 Aug;24(4):250-7. doi: 10.1089/nat.2014.0487.
- Hitherto, several aptamers have been selected against cell surface molecules. The use of these aptamers for in vivo applications requires the prior in-depth in vitro evaluation of cell specific binding. Here, we demonstrate the in vitro tests, which are imperatively necessary to evaluate aptamers pr
- PMID 25054517
- TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells.
- Liang XH1, Shen W2, Sun H2, Prakash TP3, Crooke ST2.
- Nucleic acids research.Nucleic Acids Res.2014 Aug 1;42(12):7819-32. doi: 10.1093/nar/gku484. Epub 2014 May 26.
- Phosphorothioate (PS) antisense oligonucleotides (ASOs) have been successfully developed as drugs to reduce the expression of disease-causing genes. PS-ASOs can be designed to induce degradation of complementary RNAs via the RNase H pathway and much is understood about that process. However, interac
- PMID 24861627
Japanese Journal
- The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice
- Hatakeyama Hiroto,Murata Manami,Sato Yusuke,Takahashi Mayumi,Minakawa Noriaki,Matsuda Akira,Harashima Hideyoshi
- Journal of controlled release 173, 43-50, 2014-01-10
- … Anti-microRNA oligonucleotides including 2'-OMe and phosphorothioate modifications against miR-122 (AMO122) were encapsulated in the YSK05-MEND. …
- NAID 120005476214
- In vitro optimization of 2 '-OMe-4 '-thioribonucleoside-modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle
- Takahashi Mayumi,Yamada Naoki,Hatakeyama Hiroto,Murata Manami,Sato Yusuke,Minakawa Noriaki,Harashima Hideyoshi,Matsuda Akira
- Nucleic acids research 41(22), 10659-10667, 2013-12
- … 2'-O-Methyl (2'-OMe)-4'-thioRNA is a hybrid type of chemically modified oligonucleotide, exhibiting high binding affinity to complementary RNAs and high resistance to nuclease degradation. … Further investigation showed that phosphorothioate modification contributed to long-term miR-122 inhibition by the 2'-OMe-4'-thioribonucleoside-modified AMO. …
- NAID 120005394557
- Restoration of antibiotic susceptibility in fluoroquinolone-resistant Escherichia coli by targeting acrB with antisense phosphorothioate oligonucleotide encapsulated in novel anion liposome
- MENG Jingru,BAI Hui,JIA Min,MA Xue,HOU Zheng,XUE Xiaoyan,ZHOU Ying,LUO Xiaoxing
- Journal of antibiotics 65(3), 129-134, 2012-03-25
- NAID 10030711067
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| 関連記事 | 「phosphorothioated」「oligonucleotide」「phosphorothioate」 |
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