Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/04/08 20:21:45」(JST)

wiki en

D-3-phosphoglycerate dehydrogenase is an enzyme that in humans is encoded by the PHGDH gene.^[1]

3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.^[1] Certain breast cancers are dependent on the overexpression of PHGDH.^[2]

References

^ ^a ^b "Entrez Gene: PHGDH phosphoglycerate dehydrogenase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26227.
^ Possemato, Richard; Marks, Kevin M., Shaul, Yoav D., Pacold, Michael E., Kim, Dohoon, Birsoy, Kıvanç, Sethumadhavan, Shalini, Woo, Hin-Koon, Jang, Hyun G., Jha, Abhishek K., Chen, Walter W., Barrett, Francesca G., Stransky, Nicolas, Tsun, Zhi-Yang, Cowley, Glenn S., Barretina, Jordi, Kalaany, Nada Y., Hsu, Peggy P., Ottina, Kathleen, Chan, Albert M., Yuan, Bingbing, Garraway, Levi A., Root, David E., Mino-Kenudson, Mari, Brachtel, Elena F., Driggers, Edward M., Sabatini, David M. (17 August 2011). "Functional genomics reveal that the serine synthesis pathway is essential in breast cancer". Nature 476 (7360): 346–350. doi:10.1038/nature10350.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症 phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency
2. グルコース-6-リン酸脱水素酵素欠損症の診断および治療 diagnosis and treatment of glucose 6 phosphate dehydrogenase deficiency
3. グルコースおよびグリコーゲン代謝の遺伝性疾患の概要 overview of inherited disorders of glucose and glycogen metabolism
4. 代謝性ミオパチーへのアプローチ approach to the metabolic myopathies
5. 乳酸脱水素酵素欠損症 lactate dehydrogenase deficiency

English Journal

Comparative analysis of the hepatopancreas transcriptome of grass carp (Ctenopharyngodon idellus) fed with lard oil and fish oil diets.

Tian JJ1, Lu RH2, Ji H3, Sun J1, Li C1, Liu P1, Lei CX1, Chen LQ4, Du ZY4.
Gene.Gene.2015 Jul 10;565(2):192-200. doi: 10.1016/j.gene.2015.04.010. Epub 2015 Apr 10.
n-3 highly unsaturated fatty acids (n-3 HUFAs) have been shown to suppress lipid accumulation and improve protein utilization in grass carp; however, little is known about the underlying molecular mechanism. Hence, we analyzed the hepatopancreas transcriptome of grass carp (Ctenopharyngodon idellus)
PMID 25865300

Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease.

Triplett JC1, Zhang Z, Sultana R, Cai J, Klein JB, Büeler H, Butterfield DA.
Journal of neurochemistry.J Neurochem.2015 Jun;133(5):750-65. doi: 10.1111/jnc.13039. Epub 2015 Mar 1.
Parkinson's disease (PD) is an age-related, neurodegenerative motor disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta and presence of α-synuclein-containing protein aggregates. Mutations in the mitochondrial Ser/Thr kinase PTEN-induced
PMID 25626353

Evaluation of a Hypoxia Regulated Gene Panel in Ovarian Cancer.

Baker AF1, Malm SW, Pandey R, Laughren C, Cui H, Roe D, Chambers SK.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society.Cancer Microenviron.2015 May 22. [Epub ahead of print]
A panel of nine hypoxia regulated genes, selected from a previously published fifty gene panel, was investigated for its ability to predict hypoxic ovarian cancer phenotypes. All nine genes including vascular endothelial growth factor A, glucose transporter 1, phosphoglycerate mutase 1, lactate dehy
PMID 25998313

Japanese Journal

養殖ブリやけ肉における筋形質タンパク質の変化

梁簫,吉田朝美,長富潔 [他],原研治
日本食品化学学会誌 19(1), 14-22, 2012-04-23
SDS-PAGE法及び二次元電気泳動法を用いて、養殖ブリやけ肉発生に伴う筋形質タンパク質の変化を調べた。やけ肉発生時に減少した筋形質タンパク質を質量分析法(MALDI-QIT-TOFMS)法により分析したところ、グリコーゲンホスホリラーゼ(PYMG)、ホスホグリセリン酸キナーゼ(PGK)、クレアチンキナーゼ(CK)、グリセルアルデヒド三リン酸脱水素酵素(GAPDH)、乳酸脱水素酵素(LDH)及びア …
NAID 110009436676

Detection of D-3-phosphoglycerate dehydrogenase autoantibodies in patients with autoimmune hepatitis : Clinical significance evaluation

XIANG Daijun,XIA Qing,CHEN Dexi,FENG Xia,ZHAO Yan,LIU Yan,LIAO Huiyu,LIU Yanmin,LI Ning,YAN Huiping
Hepatology research : the official journal of the Japan Society of Hepatology 41(9), 867-876, 2011-09-01
NAID 10031144159

Role of satellite cell-derived l-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy

Kiya T,Kawamata T,Namiki A,Yamakage M
NEUROSCIENCE 174, 190-199, 2011-02-03
… Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and L-serine concentration were examined. …
NAID 120005248088

Related Pictures

★リンクテーブル★

リンク元	「ホスホグリセリン酸脱水素酵素」「ホスホグリセリン酸デヒドロゲナーゼ」
関連記事	「dehydrogenase」「dehydrogenases」「phosphoglycerate」

「ホスホグリセリン酸脱水素酵素」

Phosphoglycerate dehydrogenase
	; PDB rendering based on 2g76.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2G76
Identifiers
Symbols	PHGDH; 3-PGDH; 3PGDH; PDG; PGAD; PGD; PGDH; SERA
External IDs	OMIM: 606879 MGI: 1355330 HomoloGene: 39318 GeneCards: PHGDH Gene
EC number	1.1.1.95
Gene Ontology
Molecular function	• phosphoglycerate dehydrogenase activity; • phosphoglycerate dehydrogenase activity; • electron carrier activity; • oxidoreductase activity; • cofactor binding; • NAD binding;
Cellular component	• cytosol;
Biological process	• L-serine biosynthetic process; • L-serine biosynthetic process; • brain development; • cellular amino acid biosynthetic process; • cellular nitrogen compound metabolic process; • small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;