phosphodiesterase type 5 inhibitors

出典: meddic

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  • How to treat erectile dysfunction in men with diabetes: from pathophysiology to treatment.
  • Hatzimouratidis K1, Hatzichristou D.
  • Current diabetes reports.Curr Diab Rep.2014 Nov;14(11):545. doi: 10.1007/s11892-014-0545-6.
  • Erectile dysfunction (ED) is highly prevalent affecting at least 50 % of men with diabetes mellitus (DM). DM may cause ED through a number of pathophysiological pathways. These include neuropathy, endothelial dysfunction, cavernosal smooth muscle structural/functional changes, and hormonal changes.
  • PMID 25193347
  • Treatment satisfaction with tadalafil or tamsulosin vs placebo in men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH): results from a randomised, placebo-controlled study.
  • Oelke M1, Giuliano F, Baygani SK, Melby T, Sontag A.
  • BJU international.BJU Int.2014 Oct;114(4):568-75. doi: 10.1111/bju.12733.
  • OBJECTIVES: To assess treatment satisfaction with tadalafil or tamsulosin vs placebo in a 12-week, randomised, double-blind study of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH).PATIENTS AND METHODS: After a 4-week placebo lead-in period, men aged ≥45
  • PMID 24612148


  • Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus Without Inducing Intimal Thickening
  • ICHIKAWA Yasuhiro,YOKOYAMA Utako,IWAMOTO Mari,OSHIKAWA Jin,OKUMURA Satoshi,SATO Motohiko,YOKOTA Shumpei,MASUDA Munetaka,ASOU Toshihide,ISHIKAWA Yoshihiro
  • Circulation journal : official journal of the Japanese Circulation Society 76(10), 2456-2464, 2012-09-25
  • … The purpose of this study was therefore to investigate potential DA dilators, such as phosphodiesterase 3 (PDE3) inhibitors, as alternatives to PGE1. … Conclusions: Because PDE3 inhibitors induced longer-lasting vasodilation without causing apnea or HA-mediated IT, they may be good alternatives to PGE1 for patients with DA-dependent CHD. …
  • NAID 10030875150
  • Pulmonary hypertension associated with veno-occlusive disease in systemic sclerosis: Insight into the mechanism of resistance to vasodilator
  • Tada Hayato,Konno Tetsuo,Aizu Motohiko,Yokawa Junichiro,Tsubokawa Toshinari,Fujii Hiroshi,Hayashi Kenshi,Uchiyama Katsuharu,Matsumura Masami,Kawano Mitsuhiro,Kawashiri Masa-aki,Yamagishi Masakazu
  • Journal of Cardiology Cases 5(1), e44-e47, 2012-02-00
  • … Several aggressive treatments with pulmonary vasodilators, including oral prostaglandin, endothelin receptor antagonists, and phosphodiesterase 5 inhibitors, failed to improve her symptoms. … We suggest that prevalence of veno-occlusive type of disease could be one of the major mechanisms of less responsive or even refractory to pulmonary vasodilator therapies in patients with PAH associated with connective tissue disease. …
  • NAID 120003959455


What's the best choice for erectile dysfunction? A review of the three major PDE5 inhibitors. ... Eleven distinct PDE isozymes have been identified and characterised based on several factors including amino acid sequence, substrate ...
1. Int J Clin Pract. 2006 Aug;60(8):967-75. Epub 2006 Jun 16. Comparison of phosphodiesterase type 5 (PDE5) inhibitors. Wright PJ. Author information: Belmont Surgery, Belmont, Durham, UK. Erratum ...






  • n.
(windows)ファイル内容表示(linux -> cat])
ex. type | php a.php >
formmodepatterntype specimentyped

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「write by means of a keyboard with types; "type the acceptance letter, please"」

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「a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"」

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「(biology) the taxonomic group whose characteristics are used to define the next higher taxon」

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「a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"」

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「all of the tokens of the same symbol; "the word `element'' contains five different types of character"」

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「printed characters; "small type is hard to read"」

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「identify as belonging to a certain type; "Such people can practically be typed"」

PrepTutorEJDIC   license prepejdic

「〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ」



  • n.

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「a substance that retards or stops an activity」

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「抑制する人(物) / 化学反応抑制剤」



  • n.
  • タイプで打つこと、タイピング。分類

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「writing done with a typewriter」



  • adj.
  • 型の


  [★] ホスホジエステラーゼ PDE