phosphodiesterase inhibitors

出典: meddic

PDE inhibitors

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/19 23:05:01」(JST)

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  • Nexavar/Stivarga and viagra interact to kill tumor cells.
  • Tavallai M1, Hamed HA1, Roberts JL1, Cruickshanks N1, Chuckalovcak J2, Poklepovic A3, Booth L1, Dent P1.
  • Journal of cellular physiology.J Cell Physiol.2015 Sep;230(9):2281-98. doi: 10.1002/jcp.24961.
  • We determined whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with phosphodiesterase 5 (PDE5) inhibitors such as Viagra (sildenafil) to kill tumor cells. PDE5 and PDGFRα/β were over-expressed in liver tumors compared to normal liver tissue. In multiple cell ty
  • PMID 25704960
  • KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.
  • Liou SF1, Hsu JH2,3, Chu HC4, Lin HH1, Chen IJ4, Yeh JL4.
  • Journal of cellular physiology.J Cell Physiol.2015 Sep;230(9):2038-48. doi: 10.1002/jcp.24904.
  • Phosphodiesterase (PDE) inhibitors have been suggested as a possible candidate for the treatment of osteopenia, including osteoporosis. KMUP-1 is a novel xanthine derivative with inhibitory activities on the PDE 3, 4, and 5 iso-enzymes to suppress the degradation of cAMP and cGMP. This study aimed t
  • PMID 25536014
  • Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies.
  • Dees C1, Beyer C1, Distler A1, Soare A2, Zhang Y1, Palumbo-Zerr K1, Distler O3, Schett G1, Sandner P4, Distler JH1.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2015 Aug;74(8):1621-5. doi: 10.1136/annrheumdis-2014-206809. Epub 2015 Mar 27.
  • OBJECTIVES: Stimulators of the soluble guanylate cyclase (sGC) have recently been shown to inhibit transforming growth factor-β signalling. Here, we aimed to demonstrate that riociguat, the drug candidate for clinical trials in systemic sclerosis (SSc), is effective in experimental fibrosis and to
  • PMID 25817717


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  • Pharma tribune : なりたい薬剤師になる! 7(1), 5-11, 2015-01
  • NAID 40020327767
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The development of PDE3 inhibitors to treat congestive heart failure PDE3 has high affinity for cAMP but can also hydrolyse cGMP. However, it hydrolyses cAMP at 10 times the rate it hydrolyses cGMP and therefore ...
phos·pho·di·es·ter·ase inhibitor (fŏs′fō-dī-ĕs′tə-rās′, -rāz′) n. Any of a class of drugs that suppress the enzyme phosphodiesterase ... Since phosphodiesterase inhibitors aren't natural compounds, the new analyses suggest that some ...


Erectile Dysfunction: Phosphodiesterase Repurposing phosphodiesterase-5 inhibitors Phosphodiesterase 5 inhibitors: current PHOSPHODIESTERASE INHIBITORSFIGURE 7 | Phosphodiesterase-4 inhibitors Unfortunately we are unable to provide

先読みPDE inhibitors

PDE inhibitors」


Phosphodiesterase inhibitors



  • n.

WordNet   license wordnet

「a substance that retards or stops an activity」

PrepTutorEJDIC   license prepejdic

「抑制する人(物) / 化学反応抑制剤」


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