phosphatidylinositol 4,5-bisphosphate

出典: meddic


phosphatidylinositol 4,5-biphosphate、phosphatidylinositol 4,5-diphosphate、PIP2PtdIns-4,5-P2

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/10 00:16:26」(JST)

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  • PIP kinases define PI4,5P2 signaling specificity by association with effectors.
  • Choi S1, Thapa N2, Tan X2, Hedman AC2, Anderson RA3.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jun;1851(6):711-723. doi: 10.1016/j.bbalip.2015.01.009. Epub 2015 Jan 21.
  • Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is an essential lipid messenger with roles in all eukaryotes and most aspects of human physiology. By controlling the targeting and activity of its effectors, PI4,5P2 modulates processes, such as cell migration, vesicular trafficking, cellular morphoge
  • PMID 25617736
  • PI(4,5)P2-binding effector proteins for vesicle exocytosis.
  • Martin TF1.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jun;1851(6):785-793. doi: 10.1016/j.bbalip.2014.09.017. Epub 2014 Oct 2.
  • PI(4,5)P2 participates directly in priming and possibly in fusion steps of Ca2+-triggered vesicle exocytosis. High concentration nanodomains of PI(4,5)P2 reside on the plasma membrane of neuroendocrine cells. A subset of vesicles that co-localize with PI(4,5)P2 domains appear to undergo preferential
  • PMID 25280637
  • Phosphoinositides in endocytosis.
  • Posor Y1, Eichhorn-Grünig M1, Haucke V2.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jun;1851(6):794-804. doi: 10.1016/j.bbalip.2014.09.014. Epub 2014 Sep 28.
  • The internalization and subsequent endosomal trafficking of proteins and membrane along the endocytic pathway is a fundamental cellular process. Over the last two decades, this pathway has emerged to be subject to extensive regulation by phosphoinositides (PIs), phosphorylated derivatives of the min
  • PMID 25264171


  • Negatively Charged Amino Acids Near and in Transient Receptor Potential (TRP) Domain of TRPM4 Channel Are One Determinant of Its Ca2+ Sensitivity.
  • Yamaguchi Soichiro,Tanimoto Akira,Otsuguro Ken-ichi,Hibino Hiroshi,Ito Shigeo
  • The Journal of biological chemistry 289(51), 35265-35282, 2014-12-19
  • … Transient receptor potential (TRP) channel melastatin subfamily member 4 (TRPM4) is a broadly expressed nonselective monovalent cation channel. … TRPM4 is activated by membrane depolarization and intracellular Ca2+, which is essential for the activation. …
  • NAID 120005522343
  • Changes in PtdIns(4,5)P2 Induced by Etoposide Treatment Modulates Small Intestinal P-Glycoprotein via Radixin
  • Kobori Takuro,Harada Shinichi,Nakamoto Kazuo [他]
  • Biological & pharmaceutical bulletin 37(7), 1124–1131, 2014-07
  • NAID 40020103495
  • A Novel OCRL1 Mutation in a Patient with the Mild Phenotype of Lowe Syndrome
  • , , , , ,
  • The Tohoku Journal of Experimental Medicine 232(3), 163-166, 2014
  • … Lowe syndrome is caused by mutations in the gene encoding a member of the inositol polyphosphate-5-phosphatase protein family (OCRL1) on chromosome Xq26.1. … OCRL1 contains 24 exons and encodes a 105-kDa phosphatidylinositol (4,5) bisphosphate 5-phosphatase. …
  • NAID 130004822400


Phosphoinositides regulate several actin-binding proteins but their role at intercellular adhesions has not been defined. We found that phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) was generated at sites of N-cadherin–mediated ...
In enzymology, a phosphatidylinositol-4,5-bisphosphate 3-kinase (EC is an enzyme that catalyzes the chemical reaction ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5 ...


phosphatidylinositol 4 5 bisphosphate c 8 Phosphatidylinositol 4,5-bisphosphatePhosphatidylinositol 4,5-bisphosphate diC8 » Phosphatidylinositol-4,5-bisphosphate  phosphatidylinositol (4,5) bisphosphate wiki/Phosphatidylinositol_4,5-bisphosphate

リンク元ホスファチジルイノシトール二リン酸」「ホスファチジルイノシトール2リン酸」「ホスファチジルイノシトール-4,5-二リン酸」「ホフファチジルイノシトール 4,5-ビスリン酸」「PtdIns-4,5-P2



phosphatidylinositol 4,5-bisphosphatePtdIns-4,5-P2PIP2



phosphatidylinositol 4
  • phosphatidylinositol 4,5-bisphosphate



phosphatidylinositol 4
  • phosphatidylinositol 4,5-bisphosphate

ホフファチジルイノシトール 4,5-ビスリン酸」


phosphatidylinositol 4,5-bisphosphate
phosphatidylinositol 4,5-bisphosphate



phosphatidylinositol 4,5-bisphosphatePIP2




diphosphatediphosphoric acidpyrophosphate


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