WordNet

place at intervals; "Space the interviews so that you have some time between the different candidates"
an empty area (usually bounded in some way between things); "the architect left space in front of the building"; "they stopped at an open space in the jungle"; "the space between his teeth"
the unlimited expanse in which everything is located; "they tested his ability to locate objects in space"; "the boundless regions of the infinite" (同)infinite
a blank character used to separate successive words in writing or printing; "he said the space is the most important character in the alphabet" (同)blank
a blank area; "write your name in the space provided" (同)blank space, place
an area reserved for some particular purpose; "the laboratorys floor space"
one of the areas between or below or above the lines of a musical staff; "the spaces are the notes F-A-C-E"
the time between occurrences of a repeating event; "some women do not control the spacing of their children"
the property possessed by an array of things that have space between them (同)spatial_arrangement
arranged with spaces between; often used as a combining form; "widely spaced eyes"

PrepTutorEJDIC

〈U〉『空間』,広がり / 〈U〉『宇宙』,地球の大気圏外(outer space) / 〈C〉〈U〉『間隔』,距離;《しばしば複数形で》空地 / 〈C〉(特定目的のための)『場所』 / 〈U〉《しばしばa~》時間 / 〈C〉〈U〉スペース,余白,余地 / 〈C〉線間(譜表において五線の間の部分) / …‘を'間隔をおいて配置する《+『out』+『名,』+『名』+『out』》
スペースをあけること,間隔をとること / (印刷された行・語・文の)スペース,間隔
鉱泉,温泉 / 温泉場

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/30 16:47:46」(JST)

wiki en

The perisinusoidal space (or space of Disse) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the endothelium, as well as its basement membrane,^[1] facilitates this transport.^[2] This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes (like bilirubin, for example).

The Space of Disse also contains Ito cells, also called hepatic stellate cells, which store fat or fat soluble vitamins (like vitamin A). A variety of insults that cause inflammation can result in Ito cells transforming to myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis.

The Space of Disse was named after German anatomist Joseph Disse (1852–1912).^[3]

References

^ Mescher, Anthony L. "The Circulatory System." Junquiera's Basic Histology. 12th Ed. New York: McGraw-Hill, 2010. Print. 197.
^ Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999). Robbins pathologic basis of disease. Philadelphia: Saunders. ISBN 0-7216-7335-X.
^ Haubrich WS (2004). "Disse of the space of Disse". Gastroenterology 127 (6): 1684. doi:10.1053/j.gastro.2004.10.021. PMID 15578505.

External links

UIUC Histology Subject 1317
Histology image: 22103loa – Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
Histology image: 15204loa – Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"
Anatomy photo: digestive/mammal/liver5/liver7 - Comparative Organology at University of California, Davis - "Mammal, liver (EM, Low)"

This human digestive system article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 深頸部の感染症 deep neck space infections
2. 歯性感染症の合併症、診断、および治療 complications diagnosis and treatment of odontogenic infections
3. Noncirrhotic portal hypertension
4. 小児における後咽頭部感染 retropharyngeal infections in children
5. 幼児および小児における巨頭症の病因および評価 etiology and evaluation of macrocephaly in infants and children

English Journal

Morphometric alterations, steatosis, fibrosis and active caspase-3 detection in carbamate bendiocarb treated rabbit liver.

Petrovova E, Purzyc H, Mazensky D, Luptakova L, Torma N, Sopoliga I, Sedmera D.SourceDepartment of Anatomy, Histology and Physiology, University of Veterinary Medicine and Pharmacy, Komenskeho 73, 04011, Kosice, Slovakia.
Environmental toxicology.Environ Toxicol.2013 Jul 9. doi: 10.1002/tox.21887. [Epub ahead of print]
Increasing use of pesticides all over the world makes it necessary to reveal the toxic risk in populations of nontargeted organisms. Bendiocarb is one of the 12 insecticides recommended by the World Health Organization for use in malaria control in Africa, and is used against a variety of insects. T
PMID 23836410

Oxaliplatin-related sinusoidal obstruction syndrome mimicking metastatic liver tumors.

Arakawa Y, Shimada M, Utsunomya T, Imura S, Morine Y, Ikemoto T, Hanaoka J, Sugimoto K, Bando Y.SourceDepartment of Surgery, Institute of Health Biosciences, University of Tokushima.
Hepatology research : the official journal of the Japan Society of Hepatology.Hepatol Res.2013 Jun;43(6):685-9. doi: 10.1111/j.1872-034X.2012.01114.x.
A 40-year-old woman who had undergone a curative low anterior resection for advanced rectal cancer was admitted to our hospital. She had been administrated oxaliplatin-based chemotherapy as postoperative adjuvant chemotherapy. The contrast-enhanced computed tomography revealed three hypovascular tum
PMID 23730707

Japanese Journal

Epigenetic Modifications in Hepatic Stellate Cells Contribute to Liver Fibrosis

The Tohoku Journal of Experimental Medicine 229(1), 35-43, 2013
NAID 130004460041

腎不全，肝不全が急速に進行したＬｉｇｈｔ　Ｃｈａｉｎ　Ｄｅｐｏｓｉｔｉｏｎ　Ｄｉｓｅａｓｅ（ＬＣＤＤ）の１症例

日本腎臓学会誌 49(4), 459-463, 2007
NAID 130004170810

Tubulovesicle Network in the Intercellular Space between Hepatocytes of Laboratory Animals : A Freeze-Fracture Study

群馬保健学紀要 25, 133-137, 2005-03
NAID 110004599268

Related Pictures

★リンクテーブル★

リンク元	「類洞周囲腔」
関連記事	「space」「SPACE」「spacing」

「類洞周囲腔」

Perisinusoidal space
	Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.
	Basic liver structure
Details
Latin	spatium perisinusoideum
Identifiers
Code	TH H3.04.05.0.00012
	Anatomical terminology