類洞周囲腔
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/01 14:48:39」(JST)
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| Perisinusoidal space |
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Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago.
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Basic liver structure
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| Details |
| Latin |
spatium perisinusoideum |
| Identifiers |
| Code |
TH H3.04.05.0.00012 |
| TH |
H3.04.05.0.00012 |
| Anatomical terminology
[edit on Wikidata]
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The perisinusoidal space (or space of Disse) is a location in the liver between a hepatocyte and a sinusoid. It contains the blood plasma. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be absorbed by the hepatocytes. Fenestration and discontinuity of the endothelium, as well as its basement membrane,[1] facilitates this transport.[2] This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes (like bilirubin, for example).
The Space of Disse also contains Ito cells, also called hepatic stellate cells, which store fat or fat soluble vitamins (like vitamin A). A variety of insults that cause inflammation can result in Ito cells transforming to myofibroblasts, resulting in collagen production, fibrosis, and cirrhosis.
The Space of Disse was named after German anatomist Joseph Disse (1852–1912).[3]
References
- ^ Mescher, Anthony L. "The Circulatory System." Junquiera's Basic Histology. 12th Ed. New York: McGraw-Hill, 2010. Print. 197.
- ^ Robbins, Stanley L.; Cotran, Ramzi S.; Kumar, Vinay; Collins, Tucker (1999). Robbins pathologic basis of disease. Philadelphia: Saunders. ISBN 0-7216-7335-X.
- ^ Haubrich WS (2004). "Disse of the space of Disse". Gastroenterology 127 (6): 1684. doi:10.1053/j.gastro.2004.10.021. PMID 15578505.
External links
- UIUC Histology Subject 1317
- Histology image: 22103loa – Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
- Histology image: 15204loa – Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver; sinusoids and Kupffer cells"
- Anatomy photo: digestive/mammal/liver5/liver7 - Comparative Organology at University of California, Davis - "Mammal, liver (EM, Low)"
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Accessory digestive glands
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| Liver |
- Bare area of the liver
- Ligamentum venosum
- Porta hepatis
- Round ligament of liver
- Lobes
- Left
- Right (Caudate
- Quadrate)
- Fibrous capsule of Glisson
- Perisinusoidal space
- Liver sinusoid
- Periportal space
- Portal triad
- Lobules of liver
- Microanatomy
- Hepatocyte
- Hepatic stellate cell
- Kupffer cell
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| Biliary tract |
| Bile ducts |
- Intrahepatic bile ducts
- Bile canaliculus
- Canals of Hering
- Interlobular bile ducts
- Left hepatic duct
- Right hepatic duct
- Common hepatic duct
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| Gallbladder |
- Cystic duct
- Common bile duct
- Ampulla of Vater
- Cells
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| Pancreas |
- Gross
- Tail
- Body
- Neck
- Head (Uncinate process)
- Ducts
- Microanatomy
- Pancreatic islets
- Centroacinar cell
- stellate cell
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Index of digestion
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| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
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| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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English Journal
- Ultrastructural changes in livers of young and aging rats exposed to methylated benzenes.
- Bowers DE Jr, Cannon MS, Jones DH.AbstractULtrastructural examination was conducted on livers of young rats which were given (intraperitoneal injection) several methylated benzenes (73 mg/kg of body weight) for 3 consecutive days and on livers of aging rats (12 to 19 months old) which were fed methylated benzenes in the diet (200 mg/1,000 g of feed) for periods of 1, 2, 3, and 6 months. The young animals demonstrated white, raised, nodular lesions along the free margins of the liver. The lesions in young animals consisted of lipid droplets surrounded by macrophages and fibroblasts. Some fibroblasts in these lesions appeared to be active in collagen synthesis. Mast cells and eosinophils also occurred in the lesions. Hepatocytes in these young animals appeared morphologically normal. In contrast, hepatocytes in the aging rats developed 2 types of vacuoles. The 1st type of vacuole was bound by a double-unit membrane--the other unit membrane possibly derived from smooth endoplasmic reticulum; it contained a mottled, globular, electron-lucent material. The 2nd type of vacuole was peripherally located in hepatocytes, was single membrane-bound, and occasionally was observed opening into the space of Disse (spatium perisinusoideum). Our observations indicated that acute exposures (3 days) to at least some methylated benzenes does not cause ultrastructurally observable abnormalities in hepatocytes of young rats, but chronic oral ingestion of some can cause formation of vacuolar structures in aging rat hepatocytes.
- American journal of veterinary research.Am J Vet Res.1982 Apr;43(4):679-83.
- ULtrastructural examination was conducted on livers of young rats which were given (intraperitoneal injection) several methylated benzenes (73 mg/kg of body weight) for 3 consecutive days and on livers of aging rats (12 to 19 months old) which were fed methylated benzenes in the diet (200 mg/1,000 g
- PMID 7073090
Related Links
- Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. Scanning electron micrograph by Robin Fraser, University of Otago. Hepatic structure2.svg. Basic liver structure. Latin, spatium perisinusoideum. Code, TH H3.04.05.
- The 2nd type of vacuole was peripherally located in hepatocytes, was single membrane-bound, and occasionally was observed opening into the space of Disse (spatium perisinusoideum). Our observations indicated that acute exposures (3 ...
★リンクテーブル★
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- 英
- perisinusoidal space
- ラ
- spatium perisinusoideum
- 同
- ディッセ腔, Disse腔, Disse space, space of Disse
- 関
- 類洞周囲腔