WordNet

material of a particular kind or constitution; "the immune response recognizes invading substances"
a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
the real physical matter of which a person or thing consists; "DNA is the substance of our genes"
having a number or series of holes; "a perforated steel plate"; "perforated cancellation"; "perforated stamp"

PrepTutorEJDIC

〈U〉『物質』,物 / 〈U〉《the~》(…の)『趣旨』,本音《+of+名》 / 〈U〉(スープなどの)濃さ,こく,中身[の詰まっていること] / 〈U〉『実質』,実 / 〈U〉《古》財産,資産
…‘に'穴をあける,‘を'突き通す / 〈紙など〉‘に'ミシン目を入れる,(穴で)切り取り線をつける / (…に)穴をあける,(…を)貫通する《+『into(through)』+『名』》

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1. 重複診断：重度の精神障害と物質使用障害 dual diagnosis severe mental illness and substance use disorders
2. 不安障害および物質使用障害を併発した場合の治療 treatment of co occurring anxiety disorders and substance use disorders
3. 物質使用障害（SUD）：一般診療における認識と評価の原則 substance use disorders principles for recognition and assessment in general medical care
4. HIV感染患者における薬物乱用および中毒 substance abuse and addiction in hiv infected patients
5. 物質使用障害に対する動機づけ面接 motivational interviewing for substance use disorders

β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.

Connor M1, Bagley EE, Chieng BC, Christie MJ.
British journal of pharmacology.Br J Pharmacol.2015 Jan;172(2):492-500. doi: 10.1111/bph.12673. Epub 2014 Jul 1.
BACKGROUND AND PURPOSE: Tolerance to the behavioural effects of morphine is blunted in β-arrestin-2 knockout mice, but opioid withdrawal is largely unaffected. The cellular mechanisms of tolerance have been studied in some neurons from β-arrestin-2 knockouts, but tolerance and withdrawal mechanism
PMID 24597632

Complex investigation of the effects of lambertianic acid amide in female mice under conditions of social discomfort.

Avgustinovich DF1, Fomina MK, Sorokina IV, Tolstikova TG.
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2014 Sep;157(5):583-7. doi: 10.1007/s10517-014-2621-y. Epub 2014 Sep 26.
The effects of chronic administration of a new substance lambertianic acid amide and previously synthesized methyl ester of this acid were compared in female mice living under conditions of social discomfort. For modeling social discomfort, female mouse was housed for 30 days in a cage with aggressi
PMID 25257419

Gao B1, Xue X1, Tai W2, Zhang J1, Chang H3, Ma X1, Qi Y1, Cui L3, Yan F3, Pan L1.
Oncology letters.Oncol Lett.2014 Sep;8(3):1119-1122. Epub 2014 Jun 16.
The present study aimed to investigate polypoid colonic metastases from gastric stump carcinoma by performing a retrospective analysis of the clinical data of a patient with such a diagnosis, and by discussing other previous case studies from the literature. The patient of the present study was an 8
PMID 25120669

On-chip genotoxic bioassay based on bioluminescence reporter system using three-dimensional microfluidic network

Maehana Koji,Tani Hirofumi,Kamidate Tamio
Analytica Chimica Acta 560(1-2), 24-29, 2006-02-23
… In this method, the assay was conducted in three-dimensional microfluidic network constructed by a silicon perforated microwell array chip and two poly(dimethylsiloxane) (PDMS) multi-microchannel chips. … The optimum conditions of the assay in the on-chip format have been investigated using mitomycin C (MMC) as a genotoxic substance. …
NAID 120000955371

山本健人,欠畑誠治,山田武千代,赤池紀扶,斎藤武久,斎藤等
Otology Japan 5(2), 112-118, 1995-05-15
… This review describes the recent studies of intracellular signaling pathways in dissociated outer hair cells (OHCs) of guinea-pig cochlea by using both the conventional whole-cell mode and the nystatin perforated-patch mode. … Substance P (SP) response, decreasing the non-selective cation channel conductance, was involved in pertussis toxin (PTX)-insensitive G protein, but not in any second messengers. …
NAID 10009317390