出典: meddic


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「a disease caused by deficiency of niacin or tryptophan (or by a defect in the metabolic conversion of tryptophan to niacin); characterized by gastrointestinal disturbances and erythema and nervous or mental disorders; may be caused by malnutrition or alcoholism or other nutritional impairments」
Alpine scurvy, mal de la rosa, mal rosso, maidism, mayidism, Saint Ignatius'' itch

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/15 16:58:35」(JST)

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  • The biochemical pathways of central nervous system neural degeneration in niacin deficiency.
  • Fu L1, Doreswamy V2, Prakash R2.
  • Neural regeneration research.Neural Regen Res.2014 Aug 15;9(16):1509-13. doi: 10.4103/1673-5374.139475.
  • Neural degeneration is a very complicated process. In spite of all the advancements in the molecular chemistry, there are many unknown aspects of the phenomena of neurodegeneration which need to be put together. It is a common sequela of the conditions of niacin deficiency. Neural degeneration in Pe
  • PMID 25317166
  • Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.
  • Shibata K1, Fukuwatari T.
  • Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2014 Aug 13:1-8. [Epub ahead of print]
  • We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the liver, kidney, blood, and uri
  • PMID 25117986
  • The Thompson-McFadden Commission and Joseph Goldberger: contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina.
  • Mooney SJ, Knox J, Morabia A.
  • American journal of epidemiology.Am J Epidemiol.2014 Aug 1;180(3):235-44. doi: 10.1093/aje/kwu134. Epub 2014 Jun 24.
  • As pellagra reached epidemic proportions in the United States in the early 20th century, 2 teams of investigators assessed its incidence in cotton mill villages in South Carolina. The first, the Thompson-McFadden Commission, concluded that pellagra was likely infectious. The second, a Public Health
  • PMID 24966221
  • Black urine due to urobilinogen in a patient with alcoholic pellagra.
  • Chindarkar NS1, Rentmeester LL2, Ly BT3, Fitzgerald RL4.
  • Clinical biochemistry.Clin Biochem.2014 Aug;47(12):1132-5. doi: 10.1016/j.clinbiochem.2014.03.016. Epub 2014 Apr 5.
  • OBJECTIVES: Systemic exposure to drugs, chemicals and foods can cause abnormally colored urine. Food exposures are typically benign, but urine discoloration due to chemicals or drugs may indicate a potentially dangerous condition. Discolored urine can also be caused by medical problems. This brief r
  • PMID 24709296


  • True Niacin Deficiency in Quinolinic Acid Phosphoribosyltransferase (QPRT) Knockout Mice (Nutrition and Food for Longevity : For the Well-Being of All : Proceedings of the 12th Asian Congress of Nutrition)
  • SHIBATA Katsumi
  • Journal of nutritional science and vitaminology 61(Suppl.), S145-147, 2015-05
  • NAID 40020444490
  • 症例報告 摂食不良と飲酒が誘因と考えられたペラグラ
  • 藤原 明子,藤本 智子,高山 かおる [他]
  • 臨床皮膚科 = Japanese journal of clinical dermatology 69(1), 42-46, 2015-01
  • NAID 40020303996
  • ナイアシン欠乏と皮膚免疫
  • 杉田 篤子,杉田 和成
  • 日本臨床免疫学会会誌 38(1), 37-44, 2015
  •   ビタミンB3として知られているナイアシンは,生体内で補酵素として働く,nicotinamide adenine dinucleotide(NAD)とnicotinamide adenine dinucleotide phosphate(NADP)の合成に必須である.ナイアシンは皮膚ランゲルハンス細胞のG protein-coupled receptor(GPR)109Aと結合し,ナイアシン摂取 …
  • NAID 130004875950
  • 症例報告 アルコール依存症患者に生じたペラグラの1例
  • 白瀬 春奈,山口 さやか,深井 恭子 [他]
  • 臨床皮膚科 67(13), 1053-1057, 2013-12
  • NAID 40019901497


Pellagra. is a vitamin deficiency disease most commonly caused by a chronic lack of niacin (vitamin B3) in the diet. It can be caused by decreased intake of niacin or tryptophan, and possibly by excessive intake of leucine. It may also result ...
Pellagra is a disorder brought on by a deficiency of the nutrient called niacin or nicotinic acid, one of the B-complex vitamins. Description. Nicotinic acid plays a crucial role in the cellular process called respiration. Respiration is the process by ...


PellagraVitamin B3-mangel fører til pellagra pellagra che colpirono milioni di personePellagrapellagraPicture 2 – Pellagra Imagepellagra Images and GraphicsPellagra

リンク元ペラグラ」「population displacement



ニコチンアミドアデニンジヌクレオチド NAD


  • 男女比=2:1。これはエストロゲンの代謝産物によってトリプトファンの代謝(つまりナイアシンの生合成?)が阻害される事による。 (HBC.498) 


  • 1. 食事中のナイアシン不足。
  • 飢餓状態にあっては、ナイアシン欠乏のみならず、トリプトファンからナイアシンを合成するための補酵素(鉄、リボフラビン、ビリドキシン)の欠乏によっても生ずる
  • 2. トリプトファン吸収障害
  • Hartnup diseaseでは細胞膜上のトリプトファン輸送機構が障害されており、小腸からの吸収、腎尿細管での再吸収が障害されるるため(HBC.498)
  • 3. 体内での大量消費

pellagra 3D

  • 皮膚炎 dermatitis
  • 下痢 diarrhea
  • 痴呆 dementia
  • (死 death)


  • 皮膚・粘膜症状:皮膚炎(色素沈着/脱出を残す)、舌炎、口角炎、口内炎
  • 神経症状:知覚障害、運動失調
  • 消化器症状:
  • 精神症状:健忘症、認知症


  • 初期症状:食欲減退、全身倦怠感、易刺激性(irritability)、腹痛、嘔吐
  • 日光照射部位の皮疹(pigmented and scaling)(Casal's necklace, 進行例で見られる) → bright red glossitis
  • 食道炎、腟炎
  • 下痢(直腸炎 proctitisや消化不良に起因する)、うつ、てんかん発作、認知症


  • トウモロコシを主食とした人々に多い:中国、アフリカ、インド。
  • 北米では、アルコール中毒、先天的に小腸と腎臓でニコチン酸の吸収が低下しているヒト(Hartnup disease)、カルチノイド症候群(トリプトファンがセロトニンに変換されて消費される)

population displacement」


In the setting of famine or population displacement, the occurrence of pellagra results from the absolute lack of niacin but also the deficiency of micronutrients required for the conversion of tryptophan to niacin (e.g., iron, riboflavin, and pyridoxine).(HIM.443)