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1. 心電図チュートリアル：心室拡大および心室肥大 ecg tutorial chamber enlargement and hypertrophy
2. 左室肥大および不整脈 left ventricular hypertrophy and arrhythmia
3. 高血圧における左室肥大の臨床的意義および治療 clinical implications and treatment of left ventricular hypertrophy in hypertension
4. 高血圧における左室肥大の定義および病因 definition and pathogenesis of left ventricular hypertrophy in hypertension
5. 左室肥大が認められる患者におけるファブリー病の臨床症状およびスクリーニング cardiac manifestations of fabry disease and screening in patients with left ventricular hypertrophy

Genetic and Pharmacological Inhibition of Rheb1-mTORC1 Signaling Exerts Cardioprotection against Adverse Cardiac Remodeling in Mice.

Wu X, Cao Y, Nie J, Liu H, Lu S, Hu X, Zhu J, Zhao X, Chen J, Chen X, Yang Z, Li X.SourceDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.
The American journal of pathology.Am J Pathol.2013 Apr 5. pii: S0002-9440(13)00189-2. doi: 10.1016/j.ajpath.2013.02.012. [Epub ahead of print]
A previous study indicated that Rheb1 is required for mammalian target of TOR complex 1 (mTORC1) signaling in the brain. However, the function of Rheb1 in the heart is still elusive. In the present study, we deleted Rheb1 specifically in cardiomyocytes and found that reduced Rheb1 levels conferred c
PMID 23567640

Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise.

Willis MS, Min JN, Wang S, McDonough H, Lockyer P, Wadosky KM, Patterson C.SourceMcAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.
Cell biochemistry and function.Cell Biochem Funct.2013 Apr 2. doi: 10.1002/cbf.2962. [Epub ahead of print]
The carboxyl terminus of Hsp70-interacting protein (CHIP) is a ubiquitin ligase/cochaperone critical for the maintenance of cardiac function. Mice lacking CHIP (CHIP-/-) suffer decreased survival, enhanced myocardial injury and increased arrhythmias compared with wild-type controls following challen
PMID 23553918

The benefits of endurance training in cardiomyocyte function in hypertensive rats are reversed within four weeks of detraining.

Carneiro-Júnior MA, Quintão-Júnior JF, Drummond LR, Lavorato VN, Drummond FR, da Cunha DN, Amadeu MA, Felix LB, de Oliveira EM, Cruz JS, Prímola-Gomes TN, Mill JG, Natali AJ.SourceDepartment of Physiological Sciences, Federal University of Espírito Santo (UFES), Vitória, Espírito Santo, Brazil.
Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2013 Apr;57:119-28. doi: 10.1016/j.yjmcc.2013.01.013. Epub 2013 Jan 30.
The aim of the present study was to verify the effects of low-intensity endurance training and detraining on the mechanical and molecular properties of cardiomyocytes from spontaneously hypertensive rats (SHRs). Male SHRs and normotensive control Wistar rats at 16-weeks of age were randomly divided
PMID 23376037

西田基宏,斎木翔太,北島直幸,仲矢道雄,佐藤陽治,黒瀬等
薬学雑誌 130(11), 1427-1433, 2010
… A canonical transient receptor potential protein subfamily member, TRPC6, which is activated by diacylglycerol and mechanical stretch, works as an upstream regulator of the Ca2+ signaling pathway required for pathological hypertrophy. … We have recently found that the inhibition of cGMP-selective phosphodiesterase 5 (PDE5) suppresses agonist- and mechanical stretch-induced hypertrophy through inhibition of Ca2+ influx in rat cardiomyocytes. …
NAID 130000451691

Long-Term Angiotensin II Blockade May Improve Not Only Hyperglycemia but Also Age-Associated Cardiac Fibrosis

JIN Denan,TAKAI Shinji,SUGIYAMA Tetsuya,HAYASHI Tetsuya,FUKUMOTO Masanori,OKU Hidehiro,KITAURA Yasushi,IKEDA Tsunehiko,MIYAZAKI Mizuo
Journal of pharmacological sciences 109(2), 275-284, 2009-02-20
… Cardiac function deteriorated in SDT rats and was accompanied by severe cardiac fibrosis, cardiac hypertrophy, and microstructural pathologic change in cardiomyocytes. …
NAID 10025734617

Effects of β-Blocker on Left Ventricular Remodeling in Rats with Volume Overload Cardiac Failure(Internal Medicine)

KOBAYASHI Masayuki,MACHIDA Noboru,TANAKA Ryou,YAMANE Yoshihisa
The journal of veterinary medical science 70(11), 1231-1237, 2008-11-25
… The effects of MP were evaluated at 1, 4 and 12 weeks post-surgery through echocardiographic, hemodynamic and pathologic studies. … In conclusion, MP did not prevent early eccentric hypertrophy in response to volume overload. …
NAID 110006987060