無動原体逆位、偏動原体逆位
WordNet
- a chemical process in which the direction of optical rotation of a substance is reversed from dextrorotatory to levorotary or vice versa
- abnormal condition in which an organ is turned inward or inside out (as when the upper part of the uterus is pulled into the cervical canal after childbirth)
- the layer of air near the earth is cooler than an overlying layer
- the act of turning inside out (同)eversion, everting
- a term formerly used to mean taking on the gender role of the opposite sex (同)sexual_inversion
- turning upside down; setting on end (同)upending
- (counterpoint) a variation of a melody or part in which ascending intervals are replaced by descending intervals and vice versa
- (genetics) a kind of mutation in which the order of the genes in a section of a chromosome is reversed
PrepTutorEJDIC
- 反対,転倒 / (文法で)倒置[法]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/04 20:43:46」(JST)
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A clay model showing why heterozygous inversion loops are visible in polytene chromosome preparations
An inversion loop in the A arm of a chromosome from an
Axarus species midge
An inversion is a chromosome rearrangement in which a segment of a chromosome is reversed end to end. An inversion occurs when a single chromosome undergoes breakage and rearrangement within itself. Inversions are of two types: paracentric and pericentric.
Paracentric inversions do not include the centromere and both breaks occur in one arm of the chromosome. Pericentric inversions include the centromere and there is a break point in each arm.
Cytogenetic techniques may be able to detect inversions, or inversions may be inferred from genetic analysis. Nevertheless, in most species small inversions go undetected. In insects with polytene chromosomes, for example Drosophila, preparations of larval salivary gland chromosomes allow inversions to be seen when they are heterozygous. This useful characteristic of polytene chromosomes was first advertised by Theophilus Shickel Painter in 1933.[1]
Inversions usually do not cause any abnormalities in carriers as long as the rearrangement is balanced with no extra or missing DNA. However, in individuals which are heterozygous for an inversion, there is an increased production of abnormal chromatids (this occurs when crossing-over occurs within the span of the inversion). This leads to lowered fertility due to production of unbalanced gametes.
The most common inversion seen in humans is on chromosome 9, at inv(9)(p12q13). This inversion is generally considered to have no harmful effects, but there is some suspicion it could lead to an increased risk for miscarriage or infertility for some affected individuals.[citation needed]
An inversion does not involve a loss of genetic information, but simply rearranges the linear gene sequence.
Families that may be carriers of inversions may be offered genetic counseling and genetic testing.[2]
References
- ^ Painter TS (1933). "A new method for the study of chromosome rearrangements and the plotting of chromosome maps". Science 78 (2034): 585–6. doi:10.1126/science.78.2034.585. PMID 17801695.
- ^ Gardner, R.J.M; Sutherland, Grant R.; Shaffer, Lisa G. (2011). "9 Inversions". Chromosome Abnormalities and Genetic Counseling (4th ed.). Oxford University Press. pp. 161–182. ISBN 978-0-19-974915-7.
- Lehtonen S, Myllys L, Huttunen S (2009). "Phylogenetic analysis of non-coding plastid DNAthtjtdjj in the presence of short inversions" (PDF-PREVIEW). Phytotaxa 1: 3–20. doi:10.11646/phytotaxa.1.1.2.
See also
- Chromosome abnormalities
- Karyotype
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Wikimedia Commons has media related to Chromosome inversion. |
Cytogenetics: chromosomes
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General
concepts |
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Classification |
- Autosome/Sex chromosome (or allosome or heterosome)
- Macrochromosome/Microchromosome
- Circular chromosome/Linear chromosome
- Extra chromosome (or accessory chromosome)
- Supernumerary chromosome
- A chromosome/B chromosome
- Lampbrush chromosome
- Polytene chromosome
- Dinoflagellate chromosomes
- Homologous chromosome
- Isochromosome
- Satellite chromosome
- Centromere position
- Metacentric
- Submetacentric
- Telocentric
- Acrocentric
- Holocentric
- Centromere number
- Acentric
- Monocentric
- Dicentric
- Polycentric
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Processes
and evolution |
- Mitosis
- Meiosis
- Structural alterations
- Chromosomal inversion
- Chromosomal translocation
- Numerical alterations
- Aneuploidy
- Euploidy
- Polyploidy
- Paleopolyploidy
- Polyploidization
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Structure |
- Nucleosome
- Telomere: Telomere-binding protein (TINF2)
- Chromatid
- Protamine
Chromatin
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- Euchromatin
- Heterochromatin
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Histone
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Centromere
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- A
- B
- C1
- C2
- E
- F
- H
- I
- J
- K
- M
- N
- O
- P
- Q
- T
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See also |
- Extrachromosomal DNA
- List of organisms by chromosome count
- List of chromosome lengths for various organisms
- List of sequenced genomes
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Index of cells
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Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
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Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
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Mutation
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Mechanisms of mutation |
- Insertion
- Deletion
- Substitution
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Mutation with respect to structure |
Point mutation
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- Nonsense mutation
- Missense mutation
- Silent mutation
- Frameshift mutation
- Dynamic mutation
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Large-scale mutation
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- Chromosomal translocations
- Chromosomal inversions
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Mutation with respect to overall fitness |
- Deleterious mutation
- Advantageous mutation
- Neutral mutation
- Nearly neutral mutation
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UpToDate Contents
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English Journal
- BCOR-CCNB3 (Ewing-like) Sarcoma: A Clinicopathologic Analysis of 10 Cases, In Comparison With Conventional Ewing Sarcoma.
- Puls F1, Niblett A, Marland G, Gaston CL, Douis H, Mangham DC, Sumathi VP, Kindblom LG.
- The American journal of surgical pathology.Am J Surg Pathol.2014 May 6. [Epub ahead of print]
- BCOR-CCNB3 fusion transcripts resulting from an X-chromosomal paracentric inversion were recently identified in a series of unclassifiable soft tissue and bone sarcomas with Ewing sarcoma-like morphology. The morphologic and clinical features of these sarcomas are, as yet, not well characterized. He
- PMID 24805859
- Gene-targeted deletion of OPCML and Neurotrimin in mice does not yield congenital heart defects.
- Ye M1, Parente F, Li X, Perryman MB, Zelante L, Wynshaw-Boris A, Chen J, Grossfeld P.
- American journal of medical genetics. Part A.Am J Med Genet A.2014 Apr;164A(4):966-74. doi: 10.1002/ajmg.a.36441. Epub 2014 Mar 10.
- Jacobsen syndrome (11q-) is a rare chromosomal disorder caused by deletions in distal11q. Many of the most common and severe congenital heart defects that occur in the general population occur in 11q-. Previous studies have demonstrated that gene-targeted deletion in mice of ETS-1, a cardiac transcr
- PMID 24616287
- Diagnostic utility of molecular and cytogenetic analysis in lipoblastoma: a study of two cases and review of the literature.
- Choi J1, Bouron Dal Soglio D, Fortier A, Fetni R, Mathonnet G, Cournoyer S, Lallier M, Isler M, Beaulieu Bergeron M, Patey N.
- Histopathology.Histopathology.2014 Apr;64(5):731-40. doi: 10.1111/his.12317. Epub 2014 Jan 17.
- AIMS: Lipoblastoma is a benign neoplasm of embryonic white fat tissue that results from the proliferation of primitive adipocytes, in which histological features can be ambiguous. In order to discriminate between lipoblastoma and other lipogenic and lipomatous tumours, we studied chromosomal alterat
- PMID 24433523
Japanese Journal
- Characterization of Three Varieties of <i>Lathyrus sativus</i> L. by Fluorescent Karyotype and RAPD Analysis
- バラタナゴ(タナゴ亜科魚類)における偏動原体逆位を伴った染色体多型
- Characterization of Four Specimens of<i> Allium sativum</i> L. by Differential Karyotype and RAPD Analysis
Related Links
- inversion 1. a turning inward, inside out, or other reversal of the normal relation of a part. 2. a chromosomal aberration due to the inverted reunion of the middle segment after breakage of a chromosome at two points, resulting in a ...
- Translations of Paracentric inversion. Paracentric inversion synonyms, Paracentric inversion antonyms. Information about Paracentric inversion in the free online English dictionary and encyclopedia. Printer Friendly forum Join the ...
Related Pictures
★リンクテーブル★
[★]
- 英
- paracentric inversion
- 関
- 無動原体逆位
[★]
- 英
- paracentric inversion
- 関
- 偏動原体逆位
[★]
- (解剖学)内反。内返し。(足・子宮などの)反転(retroflexion)。(心臓などの)逆位