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「a gene that disposes normal cells to change into cancerous tumor cells」
transforming gene

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/30 07:38:26」(JST)

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  • Apoptotic activity of 5-fluorouracil in breast cancer cells transformed by low doses of ionizing α-particle radiation.
  • Ponce-Cusi R1, Calaf GM1.
  • International journal of oncology.Int J Oncol.2016 Feb;48(2):774-82. doi: 10.3892/ijo.2015.3298. Epub 2015 Dec 18.
  • Globally, breast cancer in women is the leading cause of cancer death. This fact has generated an interest to obtain insight into breast tumorigenesis and also to develop drugs to control the disease. Ras is a proto-oncogene that is activated as a response to extracellular signals. As a member of th
  • PMID 26691280
  • Oncogenic role of the TP53-induced glycolysis and apoptosis regulator in nasopharyngeal carcinoma through NF-κB pathway modulation.
  • Zhao M1, Fan J1, Liu Y1, Yu Y1, Xu J1, Wen Q1, Zhang J1, Fu S1, Wang B1, Xiang L1, Feng J1, Wu J1, Yang L1.
  • International journal of oncology.Int J Oncol.2016 Feb;48(2):756-64. doi: 10.3892/ijo.2015.3297. Epub 2015 Dec 17.
  • The TP53-induced glycolysis and apoptosis regulator (TIGAR) is a p53 target gene, which functions to suppress reactive oxygen species (ROS) damage and protect cells from apoptosis. In this study, we investigated the role of TIGAR in nasopharyngeal carcinoma (NPC) tumorigenesis. Imnunohistochemical a
  • PMID 26691054
  • Targeting hedgehog signalling by arsenic trioxide reduces cell growth and induces apoptosis in rhabdomyosarcoma.
  • Boehme KA1, Zaborski JJ1, Riester R1, Schweiss SK1, Hopp U1, Traub F2, Kluba T2, Handgretinger R3, Schleicher SB3.
  • International journal of oncology.Int J Oncol.2016 Feb;48(2):801-12. doi: 10.3892/ijo.2015.3293. Epub 2015 Dec 15.
  • Rhabdomyosarcomas (RMS) are soft tissue tumours treated with a combination of surgery and chemotherapy. However, mortality rates remain high in case of recurrences and metastatic disease due to drug resistance and failure to undergo apoptosis. Therefore, innovative approaches targeting specific sign
  • PMID 26676886


  • Production of Growth-Related Oncogene Protein-α in a Human Oral Squamous Cell Carcinoma Cell Line Stimulated with Tumor Necrosis Factor-α: Role in Tumor Angiogenesis and Tumor Proliferation
  • Narita Norihiko,Matsumiya Tomoh,Kon Takao,Hayakari Ryo,Itoh Ryohei,Kubota Kosei,Sakaki Hirotaka,Furudate Ken,Yoshida Hidemi,Imaizumi Tadaatsu,Kobayashi Wataru,Kimura Hiroto
  • 弘前醫學 65(2/3/4), 147-155, 2014-09-30
  • NAID 110009838249
  • Drug Resistance to EGFR Tyrosine Kinase Inhibitors for Non-small Cell Lung Cancer
  • Shien Kazuhiko,Yamamoto Hiromasa,Soh Junichi,Miyoshi Shinichiro,Toyooka Shinichi
  • Acta Medica Okayama 68(4), 191-200, 2014-08
  • … These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). …
  • NAID 120005465582
  • DDR2を標的としたがん治療の可能性 (特集 注目すべき新標的と期待される次世代抗悪性腫瘍薬)


Oncogene is one of the world’s leading cancer journals. It is published weekly and covers all aspects of the structure and function of Oncogenes. ... A report that mammary tumor cells undergoing epithelial–mesenchymal transition ...
A gene that normally directs cell growth. If altered, an oncogene can promote or allow the uncontrolled growth of cancer. Alterations can be inherited or caused by an environmental exposure to carcinogens. Definition ...



リンク元癌遺伝子」「transforming gene」「cancer gene
拡張検索oncogene protein」「proto-oncogene protein c-Mos」「oncogene product」「proto-oncogene protein c-Myc」「proto-oncogene protein c-Ets-2



  • 原癌遺伝子に変異が導入されて原癌遺伝子の働きが異常になった場合、この状態の遺伝子を癌遺伝子という。
  • K-rasc-erbB2N-mycc-mycc-abl/bcrBcl-2

transforming gene」




cancer gene」

  [★] 癌遺伝子oncogene

oncogene protein」


oncogene productoncoprotein

proto-oncogene protein c-Mos」



c-Mos proteincytostatic factor

oncogene product」


oncogene proteinoncoprotein

proto-oncogene protein c-Myc」



c-Myc protein

proto-oncogene protein c-Ets-2」