nevertheless

出典: meddic

  • adv.


albeitalthoughdespiteevenin spite ofnonethelessnotwithstandingregardlessstillthoughyet

PrepTutorEJDIC   license prepejdic

「『それでもやはり』 / 『それにもかかわらず』」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/22 19:24:31」(JST)

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英文文献

  • Innovative cell therapy in the treatment of serious adverse events related to both chemo-radiotherapy protocol and acute myeloid leukemia syndrome: the infusion of mesenchymal stem cells post-treatment reduces hematopoietic toxicity and promotes hematopoietic reconstitution.
  • Fouillard L, Francois S, Bouchet S, Bensidhoum M, Elm'selmi A, Chapel A1.Author information 1Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire de Radiopathologie et de Thérapie Expérimentale, BP 17, 92262 Fontenay- aux-Roses, France. alain.chapel@irsn.fr.AbstractBone marrow stroma is damaged by chemotherapy and irradiation protocol. Bone marrow microenvironment supports haematopoiesis and comprises Mesenchymal Stem Cells (MSCs). Coinfusion of MSCs with hematopoietic stem cells (HSC) improves engraftment and accelerates haematopoietic recovery. Stroma-derived factor-1 (SDF-1) is a chemotactic factor which plays a crucial role in stem cell transplantation by enhancing the ability of HSC to engraft. In this study expression of SDF-1 in bone marrow MSCs and the level of Colony Forming Unit Fibroblast (CFU-F) were evaluated in 8 patients with Acute Myeloid leukemia (AML). Evaluation was done at diagnosis and after induction/consolidation chemotherapy before the onset of haematopoietic stem cell transplantation (HSCT). CFU-F frequency increases from diagnosis to remission. Nevertheless level of stromal derived factor-1 (SDF-1) transcripts in bone marrow MSCs of patients with AML stays low. Considering the role of SDF-1 in the homing of HSC, the consequences of SDF-1 deficiency observed in this study might be deleterious on the engraftment after HSCT and haematopoietic recovery. The whole result of this clinical study is an argument for MSC infusion to restore a normal level of SDF1 in the bone marrow microenvironment that could reduce hematopoietic toxicity of chemotherapy and improve HSC engraftment after HSCT.
  • Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Oct;14(9):842-8.
  • Bone marrow stroma is damaged by chemotherapy and irradiation protocol. Bone marrow microenvironment supports haematopoiesis and comprises Mesenchymal Stem Cells (MSCs). Coinfusion of MSCs with hematopoietic stem cells (HSC) improves engraftment and accelerates haematopoietic recovery. Stroma-derive
  • PMID 24372262
  • Diagnosis of Epstein-Barr virus infection in clinical serum samples by an SPR biosensor assay.
  • Riedel T1, Rodriguez-Emmenegger C2, de Los Santos Pereira A2, Bědajánková A3, Jinoch P3, Boltovets PM4, Brynda E2.Author information 1Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic v.v.i., Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. Electronic address: riedel@imc.cas.cz.2Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic v.v.i., Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic.3Vidia s.r.o., Nad Safinou II, no. 365, Vestec, 252 42 Jesenice u Prahy, Czech Republic.4V. Lashkaryov Institute of Semiconductor Physics, National Academy of Sciences of Ukraine, Nauki 41, 03028 Kyiv, Ukraine.AbstractLabel-free affinity biosensors offer a promising platform for the development of a new generation of medical diagnostic technologies. Nevertheless, when such sensors are used in complex biological media, adsorption of non-targeted medium components prevents the specific detection of the analyte. In this work, we introduce for the first time a biosensor assay based on surface plasmon resonance (SPR) capable of diagnosing different stages of Epstein-Barr virus (EBV) infections in clinical serum samples. This was achieved by simultaneous detection of the antibodies against three different antigens present in the virus. To prevent the interference of the fouling from serum during the measurement, the SPR chips were coated by an antifouling layer of a polymer brush of poly[oligo(ethylene glycol) methacrylate] grown by surface-initiated atom transfer radical polymerization. The bioreceptors were then attached via hybridization of complementary oligonucleotides. This allowed the sensor surface to be regenerated after measurement by disrupting the complementary pairs above the oligonucleotides' melting temperature and attaching new bioreceptors. In this way, the same sensing surface could be used repeatedly. The procedure used in this work will serve as a prototype strategy for the development of label-free affinity biosensors for diagnostics in blood serum or plasma samples. This is the first example of detection of marker of a disease in clinical serum samples by an optical affinity biosensor.
  • Biosensors & bioelectronics.Biosens Bioelectron.2014 May 15;55:278-84. doi: 10.1016/j.bios.2013.12.011. Epub 2013 Dec 10.
  • Label-free affinity biosensors offer a promising platform for the development of a new generation of medical diagnostic technologies. Nevertheless, when such sensors are used in complex biological media, adsorption of non-targeted medium components prevents the specific detection of the analyte. In
  • PMID 24389391
  • Metabolomics driven analysis of six Nigella species seeds via UPLC-qTOF-MS and GC-MS coupled to chemometrics.
  • Farag MA1, Gad HA2, Heiss AG3, Wessjohann LA4.Author information 1Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini st., P.B. 11562, Cairo, Egypt. Electronic address: mfarag73@yahoo.com.2Pharmacognosy Department, College of Pharmacy, Ain Shams University, Cairo, Egypt.3Institute for Botany, University for Natural Resources and Life Sciences (BOKU), Vienna, Austria.4Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.AbstractNigella sativa, commonly known as black cumin seed, is a popular herbal supplement that contains numerous phytochemicals including terpenoids, saponins, flavonoids, alkaloids. Only a few of the ca. 15 species in the genus Nigella have been characterized in terms of phytochemical or pharmacological properties. Here, large scale metabolic profiling including UPLC-PDA-MS and GC-MS with further multivariate analysis was utilized to classify 6 Nigella species. Under optimized conditions, we were able to annotate 52 metabolites including 8 saponins, 10 flavonoids, 6 phenolics, 10 alkaloids, and 18 fatty acids. Major peaks in UPLC-MS spectra contributing to the discrimination among species were assigned as kaempferol glycosidic conjugates, with kaempferol-3-O-[glucopyranosyl-(1→2)-galactopyranosyl-(1→2)-glucopyranoside, identified as potential taxonomic marker for N. sativa. Compared with GC-MS, UPLC-MS was found much more efficient in Nigella sample classification based on genetic and geographical origin. Nevertheless, both GC-MS and UPLC-MS support the remote position of Nigella nigellastrum in relation to the other taxa.
  • Food chemistry.Food Chem.2014 May 15;151:333-42. doi: 10.1016/j.foodchem.2013.11.032. Epub 2013 Nov 16.
  • Nigella sativa, commonly known as black cumin seed, is a popular herbal supplement that contains numerous phytochemicals including terpenoids, saponins, flavonoids, alkaloids. Only a few of the ca. 15 species in the genus Nigella have been characterized in terms of phytochemical or pharmacological p
  • PMID 24423541

和文文献

  • スイスにおける新地域政策の運営状況について ―Neuchâtel 州を中心とした実地調査をつうじた考察―
  • 田口 博雄
  • 地域イノベーション : Journal for Regional Policy Studies 6, 27-42, 2014-03-31
  • Nevertheless, this case study seems to indicate that Japan can draw some lessons for its regional policy from the NRP. … Nevertheless, Neuchâtel, involving the neighboring regions, pursues regional policy actively on four dimensions: cantonal, Jura-region, western Switzerland and trans-frontal with France. …
  • NAID 120005435602
  • 下町の学堂―河川の記憶と交差する大学の空間―
  • 佐藤 みなみ,SATO Minami
  • 法政大学大学院紀要 デザイン工学研究科編 (3), 2014-03-31
  • … The university was originally place for open discussion but, nevertheless, present universities are closed and far apart from the town life. …
  • NAID 120005423269
  • 都市域における橋上空間用途の多様性促進に向けた考察
  • 金子 修平,KANEKO Shuhei
  • 法政大学大学院紀要 デザイン工学研究科編 (3), 2014-03-31
  • … On the other hand, such multi-use bridges are technically feasible, nevertheless modern regulations limit activities except traffics on bridges. …
  • NAID 120005423259

関連リンク

nevertheless 【副】それにもかかわらず、それでもなお[やはり]、それにしても... - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。
neverthelessとは。意味や和訳。[副]((文修飾))((形式))それにもかかわらず,それでもやはり;とは言ってもNo matter what people say, it is nevertheless the truth.人が何と言おうとそれは真実ですHe had a high fever. Nevertheless, he ...

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 back door that proclaims, wisdom, patience & neverthelessneverthelessNevertheless squareNevertheless.In The Making. this album is Nevertheless , the rector of


★リンクテーブル★
リンク元even」「yet」「regardless」「though」「despite

even」

  [★]

  • adj.
  • 平らな、平均の、偶数の
  • adv.
  • (名刺、代名詞を修飾)~さえ、~すら
  • (比較級を強調)いっそう([[still])
  • 実のところ(indeed)
  • ~にもかかわらず(in spite of)
albeitalthoughaveragedespiteeven numbereven-numberedflatin spite ofmeanneverthelessnonethelessnotwithstandingplaneregardlesssmoothstillthoughyet

WordNet   license wordnet

「used as an intensive especially to indicate something unexpected; "even an idiot knows that"; "declined even to consider the idea"; "I don''t have even a dollar!"」

PrepTutorEJDIC   license prepejdic

「『平らな』,平たんな / 『同じ高さの』,同一平面の,平行の / (運動・動作・品質などが)『均一の』,規則的な,一様の,むらのない / (数・量などが)『同じの』,等しい,釣り合のとれた互角の / 『偶数の』 / 公平な,公正な(fair) / 平静な,穏やかな,落ち着いた(calm) / 貸借にない,清算済みの / 端数のない,ちょうどの,きっかりの / 《意味を強めて,不審や意外の念を含み》…『でさえも』,までも / 《比較級の前に用いて》『なおいっそう』,さらに(still,yet) / 《形容詞の前または後の用いて》(…と)すら言える;《古》《時を表す副詞の前に用いて》ちょうど / …‘を'平らにする,ならす / …‘を'釣り合わせる,平均させる《+『up』+『名』,+『名』+『up』》 / …‘の'変動をなくする,‘を'安定させる《+『out』+『名』,+『名』+『out』》」

PrepTutorEJDIC   license prepejdic

「夕べ,晩」

WordNet   license wordnet

「become even or more even; "even out the surface"」
even out

WordNet   license wordnet

「make even or more even」
even out

WordNet   license wordnet

「equal in degree or extent or amount; or equally matched or balanced; "even amounts of butter and sugar"; "on even terms"; "it was a fifty-fifty (or even) split"; "had a fifty-fifty (or even) chance"; "an even fight"」
fifty-fifty

WordNet   license wordnet

「occurring at fixed intervals; "a regular beat"; "the even rhythm of his breathing"」
regular

WordNet   license wordnet

「symmetrically arranged; "even features"; "regular features"; "a regular polygon"」
regular

WordNet   license wordnet

「to a greater degree or extent; used with comparisons; "looked sick and felt even worse"; "an even (or still) more interesting problem"; "still another problem must be solved"; "a yet sadder tale"」
yet, still

WordNet   license wordnet

「being level or straight or regular and without variation as e.g. in shape or texture; or being in the same plane or at the same height as something else (i.e. even with); "an even application of varnish"; "an even floor"; "the road was not very even"; "the picture is even with the window"」

WordNet   license wordnet

「divisible by two」

WordNet   license wordnet

「in spite of; notwithstanding; "even when he is sick, he works"; "even with his head start she caught up with him"」

WordNet   license wordnet

「to the full extent; "loyal even unto death"」

yet」

  [★]

  • adv.
  • conj.
albeitalreadyalthoughbutdespiteevenhoweverin spite ofneverthelessnonethelessnotwithstandingregardlessstillthough

WordNet   license wordnet

「up to the present time; "I have yet to see the results"; "details are yet to be worked out"」

PrepTutorEJDIC   license prepejdic

「《否定文で》『まだ』 / 《疑問文で》『もう』 / 《進行・継続を表す動詞と共に》『まだ』,今なお / 《比較級を強めて》なおいっそう,その上さらに(still) / 《通例and, butと共に》それにもかかわらず,ではあるが / 『それにもかかわらず』,ではあるが,がしかし」

WordNet   license wordnet

「within an indefinite time or at an unspecified future time; "he longed for the flowers that were yet to show themselves"; "sooner or later you will have to face the facts"; "in time they came to accept the harsh reality"」
in time


regardless」

  [★]

  • adj.
  • adv.
albeitalthoughdespiteevenin spite ofneverthelessnonethelessnotwithstandingstillthoughyet

WordNet   license wordnet

「in spite of everything; without regard to drawbacks; "he carried on regardless of the difficulties"」
irrespective, disregardless, no matter, disregarding

PrepTutorEJDIC   license prepejdic

「『むとんじゃくな』,不注意な;(…に)むとんじゃくな《+『of』+『名』》 / とにかく(anyway) / (…に)かかわらず《+『of』+『名』》」


though」

  [★]

  • conj.
albeitalthoughbutdespiteevenhoweverin spite ofneverthelessnonethelessnotwithstandingregardlessstillyet

WordNet   license wordnet

「(postpositive) however; "it might be unpleasant, though"」

PrepTutorEJDIC   license prepejdic

「『…にもかかわらず』,…だけれども)although) / 『たとえ…でも』 / 《補足的に主節の後に置いて》『もっとも…ではあるが』」


despite」

  [★]

  • prep.
albeitalthoughevenin spite ofneverthelessnonethelessnotwithstandingregardlessstillthoughyet

WordNet   license wordnet

「contemptuous disregard; "she wanted neither favor nor despite"」

PrepTutorEJDIC   license prepejdic

「…『にもかかわらず』」




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