WordNet

relating to or containing an alkali; having a pH greater than 7; "alkaline soils derived from chalk or limestone" (同)alkalic
any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphates
a mixture of soluble salts found in arid soils and some bodies of water; detrimental to agriculture
the chief phagocytic leukocyte; stains with either basic or acid dyes (同)neutrophile

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アルカリの
アルカリ,塩基

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1. 好中球増多症の患者へのアプローチ approach to the patient with neutrophilia
2. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia
3. Disorders of arousal from non-rapid eye movement sleep in adults
4. CPAP for pediatric obstructive sleep apnea
5. 原発性骨髄線維症の臨床症状および診断 clinical manifestations and diagnosis of primary myelofibrosis

English Journal

Combination of carvacrol with methotrexate suppresses Complete Freund's Adjuvant induced synovial inflammation with reduced hepatotoxicity in rats.

Banji OJ1, Banji D2, Soumya N1, Chilipi KK1, Kalpana CH1, Kranthi Kumar CH3, Annamalai AR4.Author information 1Department of Pharmacology and Toxicology, Nalanda College of Pharmacy, Cherlapally, Nalgonda 508001, A.P., India.2Department of Pharmacology and Toxicology, Nalanda College of Pharmacy, Cherlapally, Nalgonda 508001, A.P., India. Electronic address: davidbanji@gmail.com.3Department of Pharmaceutical Analysis, Nalanda College of Pharmacy, Cherlapally, Nalgonda 508001, A.P., India.4Department of Pharmacology and Toxicology, Rajah Muthiah Medical College, Annamalai University, Chitambaram, India.AbstractThe present study evaluated the therapeutic benefit of the combination of carvacrol, an isoprenoid having potential anti-inflammatory action, with methotrexate in suppressing Complete Freund's Adjuvant induced arthritis and attenuating methotrexate induced hepatic damage. Arthritis was induced in rats with Complete Freund's Adjuvant. Animals received methotrexate (2mg/kg) intraperitonealy once a week for 5 weeks alone and along with carvacrol orally (50 and 100mg/kg) respectively from the 10th to the 42nd day. Control and carvacrol alone group were also studied. Paw volume, hypernociception, and erythrocyte sedimentation rate were evaluated as arthritic markers. Hepatic marker enzymes in serum; myeloperoxidase, protein oxidation, and oxidative measures were determined in the liver homogenate. Liver histological assessments were also carried out. Methotrexate significantly controlled arthritis; however, liver damage was evident due to oxidative stress and rise in myeloperoxidase levels. Carvacrol suppressed the hyperalgesic response, significantly alleviated arthritis and reduced damage to the hepatocytes owing to a decline in the levels of myeloperoxidase and oxidative markers. High dose of the combination reduced the levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and alkaline phosphatase by 24.74%, 30.2% and 28.14% compared with methotrexate treatment. Histological assessment also revealed that carvacrol minimizes methotrexate induced liver toxicity. In combination, carvacrol promoted the anti-arthritic action of methotrexate, reduced neutrophils infiltration and peroxidative damage to the liver. Therefore, carvacrol can serve as a useful adjuvant and promote the safe use of methotrexate in the management of arthritis.
European journal of pharmacology.Eur J Pharmacol.2013 Dec 12;723C:91-98. doi: 10.1016/j.ejphar.2013.12.009. [Epub ahead of print]
The present study evaluated the therapeutic benefit of the combination of carvacrol, an isoprenoid having potential anti-inflammatory action, with methotrexate in suppressing Complete Freund's Adjuvant induced arthritis and attenuating methotrexate induced hepatic damage. Arthritis was induced in ra
PMID 24333217

Safety pharmacology--current and emerging concepts.

Hamdam J, Sethu S, Smith T, Alfirevic A, Alhaidari M, Atkinson J, Ayala M, Box H, Cross M, Delaunois A, Dermody A, Govindappa K, Guillon JM, Jenkins R, Kenna G, Lemmer B, Meecham K, Olayanju A, Pestel S, Rothfuss A, Sidaway J, Sison-Young R, Smith E, Stebbings R, Tingle Y, Valentin JP, Williams A, Williams D, Park K, Goldring C.Author information MRC Centre for Drug Safety Science, University of Liverpool, UK.AbstractSafety pharmacology (SP) is an essential part of the drug development process that aims to identify and predict adverse effects prior to clinical trials. SP studies are described in the International Conference on Harmonisation (ICH) S7A and S7B guidelines. The core battery and supplemental SP studies evaluate effects of a new chemical entity (NCE) at both anticipated therapeutic and supra-therapeutic exposures on major organ systems, including cardiovascular, central nervous, respiratory, renal and gastrointestinal. This review outlines the current practices and emerging concepts in SP studies including frontloading, parallel assessment of core battery studies, use of non-standard species, biomarkers, and combining toxicology and SP assessments. Integration of the newer approaches to routine SP studies may significantly enhance the scope of SP by refining and providing mechanistic insight to potential adverse effects associated with test compounds.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2013 Dec 1;273(2):229-41. doi: 10.1016/j.taap.2013.04.039. Epub 2013 Jun 1.
Safety pharmacology (SP) is an essential part of the drug development process that aims to identify and predict adverse effects prior to clinical trials. SP studies are described in the International Conference on Harmonisation (ICH) S7A and S7B guidelines. The core battery and supplemental SP studi
PMID 23732082

Paroxysmal nocturnal haemoglobinuria. Experience over a 10 years period.

Canalejo K, Riera Cervantes N, Felippo M, Sarandría C, Aixalá M.Author information Apoyo Médico, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina.AbstractINTRODUCTION: Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic, clonal and acquired disorder of the hematopoietic stem cell with a deficiency of all glycophosphatidyl-inositol (GPI) linked proteins. The aim of this retrospective study was to analyse haematological and biochemical data from 152 patients referred to our laboratory for diagnosis of PNH by flow cytometry (FC).
International journal of laboratory hematology.Int J Lab Hematol.2013 Nov 5. doi: 10.1111/ijlh.12156. [Epub ahead of print]
INTRODUCTION: Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic, clonal and acquired disorder of the hematopoietic stem cell with a deficiency of all glycophosphatidyl-inositol (GPI) linked proteins. The aim of this retrospective study was to analyse haematological and biochemical data from 1
PMID 24188430

Japanese Journal

好中球アルカリホスファターゼ(NAP)スコア (広範囲血液・尿化学検査免疫学的検査(第7版・2)その数値をどう読むか) -- (血球化学検査)

仲村祐子,三谷絹子
日本臨床 68(-) (970), 844-847, 2010-01
NAID 40016932973

Neutrophil alkaline phosphatase activity in respiratory viral infection

KUBOTA Masaru,HARUTA Tsunekazu
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 12(6), 387-390, 2006-12-01
NAID 10018697301