中性スフィンゴ糖脂質

WordNet

possessing no distinctive quality or characteristics
one who does not side with any party in a war or dispute
having no net electric charge (同)electroneutral
lacking distinguishing quality or characteristics; "a neutral personality that made no impression whatever"
not supporting or favoring either side in a war, dispute, or contest

PrepTutorEJDIC

『中立の』;中立国の / 『公平な』,不偏不党の / (人・物が)特色のはっきりしない;(色が)はっきりしない,くすんだ / (酸性でもアルカリ性でもない)中性の / (電気が)中性の,(物体が)帯電していない / (自動車などのギアが)ニュートラルの / (文法で)中性の / 〈C〉(戦争・論争などで)中立の人;中立国民;中立国 / 〈C〉くすんだ色,灰色 / 〈U〉(自動車などのギヤの)ニュートラル(動力のかかっていない状態・位置)

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1. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism
2. 小児の頚椎固定 pediatric cervical spine immobilization
3. 原発性高シュウ酸尿症 primary hyperoxaluria
4. 膜性腎症の原因および診断 causes and diagnosis of membranous nephropathy
5. ACE 阻害薬誘発性血管浮腫 ace inhibitor induced angioedema

English Journal

A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis.

Taguchi A, Maruyama H, Nameta M, Yamamoto T, Matsuda J, Kulkarni AB, Yoshioka H, Ishii S.AbstractFabry disease is a lysosomal storage disorder in which neutral glycosphingolipids, predominantly globotriaosylceramide (Gb3), accumulate due to deficient α-galactosidase A (α-Gal A) activity. The α-Gal A-knockout (GLAko) mouse has been used as a model for Fabry disease, but it does not have any symptomatic abnormalities. In this study, we generated a symptomatic mouse model (G3Stg/GLAko) by crossbreeding GLAko mice with transgenic mice expressing human Gb3 synthase. G3Stg/GLAko mice had high Gb3 levels in major organs, and their serum Gb3 level at 5-25 weeks of age was 6-10 times higher than that in GLAko mice of the same age. G3Stg/GLAko mice showed progressive renal impairment, with albuminuria at 3 weeks of age, decreased urine osmolality at 5 weeks, polyuria at 10 weeks, and increased blood urea nitrogen at 15 weeks. The urine volume and urinary albumin concentration were significantly reduced in the G3Stg/GLAko mice when human recombinant α-Gal A was administered intravenously. These data suggest that Gb3 accumulation is a primary pathogenic factor in the symptomatic phenotype of G3Stg/GLAko mice, and that this mouse line is suitable for studying the pathogenesis of Fabry disease and for preclinical studies of candidate therapies.
The Biochemical journal.Biochem J.2013 Oct 7. [Epub ahead of print]
Fabry disease is a lysosomal storage disorder in which neutral glycosphingolipids, predominantly globotriaosylceramide (Gb3), accumulate due to deficient α-galactosidase A (α-Gal A) activity. The α-Gal A-knockout (GLAko) mouse has been used as a model for Fabry disease, but it does not have any s
PMID 24094090

Cholesterol and glycosphingolipids of human trabecular meshwork and aqueous humor: comparative profiles from control and glaucomatous donors.

Aribindi K, Guerra Y, Piqueras Mdel C, Banta JT, Lee RK, Bhattacharya SK.SourceBascom Palmer Eye Institute, University of Miami, FL, USA.
Current eye research.Curr Eye Res.2013 Oct;38(10):1017-26. doi: 10.3109/02713683.2013.803123. Epub 2013 Jun 21.
PURPOSE: To determine the differential profiles of cholesterol and glycosphingolipid species and their quantitative differences between control and glaucomatous aqueous humor (AQH) and the trabecular meshwork (TM) derived from human donors.METHODS: Control TM and selected primary open angle glaucoma
PMID 23790057

New insights on glucosylated lipids: metabolism and functions.

Ishibashi Y, Kohyama-Koganeya A, Hirabayashi Y.SourceLaboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama, Japan.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Sep;1831(9):1475-85. doi: 10.1016/j.bbalip.2013.06.001. Epub 2013 Jun 13.
Ceramide, cholesterol, and phosphatidic acid are major basic structures for cell membrane lipids. These lipids are modified with glucose to generate glucosylceramide (GlcCer), cholesterylglucoside (ChlGlc), and phosphatidylglucoside (PtdGlc), respectively. Glucosylation dramatically changes the func
PMID 23770033

Japanese Journal

Structural Elucidation of the Neutral Glycosphingolipids, Mono-, Di-, Tri- and Tetraglycosylceramides from the Marine Crab Erimacrus isenbeckii

Kimura Koji,Itonori Saki,Kajiwara Chiho [他]
Journal of Oleo Science 63(3), 269-280, 2014-03
NAID 40019986022

Structural Elucidation of the Neutral Glycosphingolipids, Mono-, Di-, Tri- and Tetraglycosylceramides from the Marine Crab Erimacrus isenbeckii

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Journal of Oleo Science 63(3), 269-280, 2014
… The neutral glycosphingolipids, mono-, di-, tri- and tetraglycosylceramides (GL-1, GL-2, GL-3, GL-4a and GL-4b), were identified from whole tissues of the marine crab Erimacrus isenbeckii by successive column chromatography with ion exchange Sephadex (QAE-Sephadex), magnesium silicate (Florisil) and silicic acid (Iatrobeads) resins. … By immunological detection, an arthro-series glycosphingolipid (At3Cer; …
NAID 130004436120

Synthetic Studies on Glycosphingolipids from Protostomia Phyla: Synthesis of Glycosphingolipids from the Parasite Schistosoma mansoni

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Chemical and Pharmaceutical Bulletin 58(6), 811-817, 2010
… Synthetic access to three neutral glycosphingolipids from the parasite Schistosoma mansoni adult worm has been achieved. …
NAID 130000255853