WordNet
- (physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
- instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
- a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
- a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
- a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
- a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
- the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
PrepTutorEJDIC
- 〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
UpToDate Contents
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- 1. 二次性中枢神経系リンパ腫の臨床症状および診断 clinical presentation and diagnosis of secondary central nervous system lymphoma
- 2. 中枢神経系病変を有するHIV感染患者に対するアプローチ approach to hiv infected patients with central nervous system lesions
- 3. 中枢神経系シャントおよび他のデバイスの感染 infections of central nervous system shunts and other devices
- 4. 成人における中枢神経系の原発性血管炎 primary angiitis of the central nervous system in adults
- 5. 心不全におけるアンギオテンシン変換酵素阻害剤およびアンギオテンシン受容体拮抗剤：作用機序 angiotensin converting enzyme inhibitors and receptor blockers in heart failure mechanisms of action
English Journal
- P2X7 receptors in neurohypophysial terminals: evidence for their role in arginine-vasopressin secretion.
- Cuadra AE, Custer EE, Bosworth EL, Lemos JR.Author information Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts.AbstractArginine-vasopressin (AVP) plays a major role in maintaining cardiovascular function and related pathologies. The mechanism involved in its release into the circulation is complex and highly regulated. Recent work has implicated the purinergic receptor, P2X7R, in a role for catecholamine-enhanced AVP release in the rat hypothalamic-neurohypophysial (NH) system. However, the site of P2X7R action in this endocrine system, and whether or not it directly mediates release in secretory neurons have not been determined. We hypothesized that the P2X7R is expressed and mediates AVP release in NH terminals. P2X7R function was first examined by patch-clamp recordings in isolated NH terminals. Results revealed that subpopulations of isolated terminals displayed either high ATP-sensitivity or low ATP-sensitivity, the latter of which was characteristic of the rat P2X7R. Additional recordings showed that terminals showing sensitivity to the P2X7R-selective agonist, BzATP, were further inhibited by P2X7R selective antagonists, AZ10606120 and brilliant blue-G. In confocal micrographs from tissue sections and isolated terminals of the NH P2X7R-immunoreactivity was found to be localized in plasma membranes. Lastly, the role of P2X7R on AVP release was tested. Our results showed that BzATP evoked sustained AVP release in NH terminals, which was inhibited by AZ10606120. Taken together, our data lead us to conclude that the P2X7R is expressed in NH terminals and corroborates its role in AVP secretion.
- Journal of cellular physiology.J Cell Physiol.2014 Mar;229(3):333-42. doi: 10.1002/jcp.24453.
- Arginine-vasopressin (AVP) plays a major role in maintaining cardiovascular function and related pathologies. The mechanism involved in its release into the circulation is complex and highly regulated. Recent work has implicated the purinergic receptor, P2X7R, in a role for catecholamine-enhanced AV
- PMID 24037803
- Male endocrine dysfunction.
- Hotaling JM, Patel Z.Author information Division of Urology, Department of Surgery, School of Medicine, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA. Electronic address: jim.hotaling@gmail.com.AbstractEvaluation for endocrine function is a pivotal part of the male infertility workup. Endocrine dysfunction may result from endogenous and exogenous sources. This article describes the traditional roles that the hypothalamic-pituitary-gonadal endocrine axis plays in spermatogenesis and testicular dysfunction, as well as other insults that may contribute to hypospermatogenesis. Recent research into the role alternative hormonal axes play in spermatogenesis and promising new technologies that may correct inborn or acquired endocrinopathies leading to impaired sperm growth and maturation are discussed.
- The Urologic clinics of North America.Urol Clin North Am.2014 Feb;41(1):39-53. doi: 10.1016/j.ucl.2013.08.010. Epub 2013 Oct 3.
- Evaluation for endocrine function is a pivotal part of the male infertility workup. Endocrine dysfunction may result from endogenous and exogenous sources. This article describes the traditional roles that the hypothalamic-pituitary-gonadal endocrine axis plays in spermatogenesis and testicular dysf
- PMID 24286766
- Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus.
- Black JA1, Vasylyev D2, Dib-Hajj SD3, Waxman SG4.Author information 1Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address: joel.black@yale.edu.2Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address: dmytro.vasylyev@yale.edu.3Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address: sulayman.dib-hajj@yale.edu.4Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address: stephen.waxman@yale.edu.AbstractOsmoregulation in mammals is tightly controlled by the release of vasopressin and oxytocin from magnocellular neurosecretory cells (MSC) of the supraoptic nucleus (SON). The release of vasopressin and oxytocin in the neurohypophysis by axons of MSC is regulated by bursting activity of these neurons, which is influenced by multiple sources, including intrinsic membrane properties, paracrine contributions of glial cells, and extrinsic synaptic inputs. Previous work has shown that bursting activity of MSC is tetrodotoxin (TTX)-sensitive, and that TTX-S sodium channels Nav1.2, Nav1.6 and Nav1.7 are expressed by MSC and upregulated in response to osmotic challenge in rats. The TTX-resistant sodium channels, NaV1.8 and Nav1.9, are preferentially expressed, at relatively high levels, in peripheral neurons, where their properties are linked to repetitive firing and subthreshold electrogenesis, respectively, and are often referred to as "peripheral" sodium channels. Both sodium channels have been implicated in pain pathways, and are under study as potential therapeutic targets for pain medications which might be expected to have minimal CNS side effects. We show here, however, that Nav1.9 is expressed by vasopressin- and oxytocin-producing MSC of the rat supraoptic nucleus (SON). We also show that cultured MSC exhibit sodium currents that have characteristics of Nav1.9 channels. In contrast, Nav1.8 is not detectable in the SON. These results suggest that Nav1.9 may contribute to the firing pattern of MSC of the SON, and that careful assessment of hypothalamic function be performed as NaV1.9 blocking agents are studied as potential pain therapies.
- Experimental neurology.Exp Neurol.2014 Jan 11;253C:174-179. doi: 10.1016/j.expneurol.2014.01.004. [Epub ahead of print]
- Osmoregulation in mammals is tightly controlled by the release of vasopressin and oxytocin from magnocellular neurosecretory cells (MSC) of the supraoptic nucleus (SON). The release of vasopressin and oxytocin in the neurohypophysis by axons of MSC is regulated by bursting activity of these neurons,
- PMID 24424281
Japanese Journal
- An FXPRLamide Neuropeptide Induces Seasonal Reproductive Polyphenism Underlying a Life-History Tradeoff in the Tussock Moth
- Uehara Hiroshi,Senoh Yukiko,Yoneda Kyohei,Kato Yoshiomi,Shiomi Kunihiro
- PLOS ONE 6(8), 2011-08-26
- … This gene is expressed in neurosecretory cells within the subesophageal ganglion whose axonal projections reach the neurohemal organ, the corpus cardiacum, suggesting that the DH neuroendocrine system is conserved in Lepidoptera. …
- NAID 120004702591
- Identification of a cis-regulatory element that directs prothoracicotropic hormone gene expression in the silkworm Bombyx mori
- Ohtsuka Kazunori,Atsumi Tsutomu,Fukushima Yoshihisa,Shiomi Kunihiro
- INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY 41(6), 356-361, 2011-06
- … Using an AcNPV (Autographa californica nucleopolyhedrovirus)mediated transient gene transfer system, we identified a cis-regulatory element that participates in the decision to switch expression of PTTH on or off in PTTH-producing neurosecretory cells (PTPCs). …
- NAID 80021794454
- 神経分泌細胞の同定と神経活動のイメージング
- 上田 陽一,藤原 広明
- 自律神経 = The Autonomic nervous system
- NAID 10026905345
Related Links
- Neurosecretory system information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Neurosecretory system Description of Neurosecretory system Neurosecretory ...
- 1971] KAsUGA & TAKAHASHI: Preoptic neurosecretory system of the medaka The dendrites or axons of the neurosecretory neurons were stained plainly with AF. The neurosecretory nerve tracts extending from PON ...
Related Pictures
★リンクテーブル★
| リンク元 | 「神経分泌系」「neurohemal organ」 |
| 関連記事 | 「system」「neurosecretory」 |
「神経分泌系」
「neurohemal organ」
「system」
- n.
「neurosecretory」
- 神経分泌の