WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
autosomal dominant disease characterized by numerous neurofibromas and by spots on the skin and often by developmental abnormalities (同)von Recklinghausen''s disease
informal term for information; "give me the gen on your new line of computers"

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1. 神経線維腫症2型 neurofibromatosis type 2
2. 神経線維腫症I型（NF1）：病因、臨床的特徴、および診断 neurofibromatosis type 1 nf1 pathogenesis clinical features and diagnosis
3. 神経線維腫症I型（NF1）：マネージメントおよび予後 neurofibromatosis type 1 nf1 management and prognosis
4. 髄膜腫：疫学、危険因子と病理 meningioma epidemiology risk factors and pathology
5. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia

Paganini I1, Mancini I2, Baroncelli M1, Arena G1, Gensini F1, Papi L1, Sestini R3.
The Journal of molecular diagnostics : JMD.J Mol Diagn.2014 Jul;16(4):393-9. doi: 10.1016/j.jmoldx.2014.02.007. Epub 2014 May 9.
Somatic mosaicism represents the coexistence of two or more cell populations with different genotypes in one person, and it is involved in >30 monogenic disorders. Somatic mosaicism characterizes approximately 25% to 33% of patients with de novo neurofibromatosis type 2 (NF2). The identification
PMID 24815379

The role of NF2 gene mutations and pathogenesis-related proteins in sporadic vestibular schwannomas in young individuals.

Chen H1, Zhang X, Zhang Z, Yang T, Wang Z, Wu H.
Molecular and cellular biochemistry.Mol Cell Biochem.2014 Jul;392(1-2):145-52. doi: 10.1007/s11010-014-2011-9. Epub 2014 Mar 12.
Vestibular schwannomas (VSs) are benign tumors arising from eighth cranial nerve and most often occur sporadically in individuals of middle age group. Sporadic VSs are rarely reported in the young population. In this study, we evaluated clinical behaviors of 12 young sporadic VSs by the statistical
PMID 24619252

Cutaneous and ophthalmic signs as a clue to early diagnosis of severe neurofibromatosis type 2: report of a novel mutation that predicts this poor prognosis.

Casado-Verrier B1, Feito-Rodriguez M, Noval S, Martínez-Glez V, Lapunzina P, De Lucas-Laguna R.
Clinical and experimental dermatology.Clin Exp Dermatol.2014 Jun;39(4):557-9. doi: 10.1111/ced.12306. Epub 2014 Apr 8.
PMID 24708049

尾上義浩,小池修治,那須隆 [他],野田大介,石田晃弘,石井健一,青柳優
耳鼻咽喉科臨床 102(11), 931-937, 2009-11-01
… We report a case of leiomyosarcoma of the nasal cavity with neurofibromatosis type 1 (NF1). … The risk of malignancy among NF1 patients is higher than among the general population, i.e., the NF1 gene is a tumor suppressor gene of which mutation involves a fourfold increased risk for cancer. … The NF1 gene product neurofibromin is thought to deliver much of its function by downregulating the oncogene ras. …
NAID 10025527376

GASTRIC SCHWANNOMA WITH ADJACENT EXTERNAL PROGRESSION HARBORED ABERRANT NF2 GENE

OGASAWARA NAOTAKA,SASAKI MAKOTO,ISHIGURO HIDEYUKI,ITOH YUKIMI,NOJIRI SYUNSUKE,KUBOTA EIJI,WADA TSUNEYA,KATAOKA HIROMI,KUWABARA YOSHIYUKI,JOH TAKASHI
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 21(3), 192-195, 2009-07-01
NAID 10026611357

Inducible and Transmissible Genetic Events and Pediatric Tumors of the Nervous System

Rice Jerry M.,NAKANE Chiyoko,TAKIMOTO Koichi
Journal of radiation research 47(Supplement_B), B1-B11, 2006-09-00
… Tumors of the nervous system most often occur in both children and adults as sporadic events with no family history of the disease, but they are also among the clinical manifestations of a significant number of familial cancer syndromes, including familial retinoblastoma, neurofibromatosis 1 and 2, tuberous sclerosis, and Cowden, Turcot, Li-Fraumeni and nevoid basal cell carcinoma (Gorlin) syndromes. …
NAID 110004810212