neurofibrillary tangles

出典: meddic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/16 22:41:36」(JST)

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  • Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
  • Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, Lutz B, Behl C, Clement AB.SourceInstitute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
  • Neurobiology of aging.Neurobiol Aging.2013 Nov;34(11):2574-84. doi: 10.1016/j.neurobiolaging.2013.05.027. Epub 2013 Jul 6.
  • Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits. Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition. Here, we studied the impact of cannabin
  • PMID 23838176
  • Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.
  • Armato U, Chiarini A, Chakravarthy B, Chioffi F, Pacchiana R, Colarusso E, Whitfield JF, Dal Prà I.SourceDepartment of Life and Reproduction Sciences, University of Verona Medical School, Verona, Italy.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1832(10):1634-52. doi: 10.1016/j.bbadis.2013.04.020. Epub 2013 Apr 26.
  • The "amyloid-β (Aβ) hypothesis" posits that accumulating Aβ peptides (Aβs) produced by neurons cause Alzheimer's disease (AD). However, the Aβs contribution by the more numerous astrocytes remains undetermined. Previously we showed that fibrillar (f)Aβ25-35, an Aβ42 proxy, evokes a surplus en
  • PMID 23628734


  • 石灰化を伴うびまん性神経原線維変化病(DNTC) (特集 脳変性疾患の臨床神経病理学から精神症状を再考する) -- (その他の変性疾患の病理と精神症状)
  • Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases







  • vt.
  • もつれさせる(up)。(妨げるような具合に)巻き込む。絡み合わせる。紛糾させる。当惑させる、網にかける、からめとる、陥れる
  • vi.
  • もつれる。紛糾する。混乱する、巻き添えを食う。
  • n.
  • もつれ。当惑、困却。混乱、ごたごた、紛糾
tanglement, tangler

WordNet   license wordnet

「something jumbled or confused; "a tangle of government regulations"」
snarl, maze

WordNet   license wordnet

「a twisted and tangled mass that is highly interwoven; "they carved their way through the tangle of vines"」

PrepTutorEJDIC   license prepejdic

「〈糸など〉‘を'『もつれさせる』;(…と)…‘を'もつれさせる《+名+with+名》 / …‘を'『紛糾させる』,こみいらせる / もつれる / 紛糾する / 《話》(…と)けんかする《+with+名》 / もつれ / 紛糾 / 《話》けんか,仲たがい」



  • 神経原線維の