neurofibrillary tangles

出典: meddic

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/16 22:41:36」(JST)

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  • Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
  • Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, Lutz B, Behl C, Clement AB.SourceInstitute for Pathobiochemistry, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
  • Neurobiology of aging.Neurobiol Aging.2013 Nov;34(11):2574-84. doi: 10.1016/j.neurobiolaging.2013.05.027. Epub 2013 Jul 6.
  • Alzheimer's disease (AD) is characterized by amyloid-β deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits. Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition. Here, we studied the impact of cannabin
  • PMID 23838176
  • Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.
  • Armato U, Chiarini A, Chakravarthy B, Chioffi F, Pacchiana R, Colarusso E, Whitfield JF, Dal Prà I.SourceDepartment of Life and Reproduction Sciences, University of Verona Medical School, Verona, Italy.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1832(10):1634-52. doi: 10.1016/j.bbadis.2013.04.020. Epub 2013 Apr 26.
  • The "amyloid-β (Aβ) hypothesis" posits that accumulating Aβ peptides (Aβs) produced by neurons cause Alzheimer's disease (AD). However, the Aβs contribution by the more numerous astrocytes remains undetermined. Previously we showed that fibrillar (f)Aβ25-35, an Aβ42 proxy, evokes a surplus en
  • PMID 23628734


  • 石灰化を伴うびまん性神経原線維変化病(DNTC) (特集 脳変性疾患の臨床神経病理学から精神症状を再考する) -- (その他の変性疾患の病理と精神症状)
  • Quantification of neuropathological findings by image data for the diagnosis of dementia in forensic autopsy cases


Explore an interactive diagram of the formation of tangles through tau proteins and how this contributes to the development of Alzheimer's brain. / brain tour Get inside the human brain Brain Tour Brain Basics 1 2 3 4 5 6 7 8 ...
The formation of amyloid plaques and neurofibrillary tangles are thought to contribute to the degradation of the neurons (nerve cells) in the brain and the subsequent symptoms of Alzheimer's disease. Amyloid Plaques ...






  • vt.
  • もつれさせる(up)。(妨げるような具合に)巻き込む。絡み合わせる。紛糾させる。当惑させる、網にかける、からめとる、陥れる
  • vi.
  • もつれる。紛糾する。混乱する、巻き添えを食う。
  • n.
  • もつれ。当惑、困却。混乱、ごたごた、紛糾
tanglement, tangler

WordNet   license wordnet

「something jumbled or confused; "a tangle of government regulations"」
snarl, maze

WordNet   license wordnet

「a twisted and tangled mass that is highly interwoven; "they carved their way through the tangle of vines"」

PrepTutorEJDIC   license prepejdic

「〈糸など〉‘を'『もつれさせる』;(…と)…‘を'もつれさせる《+名+with+名》 / …‘を'『紛糾させる』,こみいらせる / もつれる / 紛糾する / 《話》(…と)けんかする《+with+名》 / もつれ / 紛糾 / 《話》けんか,仲たがい」



  • 神経原線維の