multidrug-resistant Streptococcus pneumoniae

多剤耐性肺炎球菌

WordNet

1. impervious to being affected; "resistant to the effects of heat"; "resistant to persuasion"
2. respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants
3. spherical Gram-positive bacteria occurring in pairs or chains; cause e.g. scarlet fever and tonsillitis (同)streptococci, strep

PrepTutorEJDIC

1. 抵抗力のある;(…に)抵抗する《+『to』+『名』》
2. 肺炎
3. 連鎖球菌

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 難治性肺炎 nonresolving pneumonia
• 2. 成人における市中肺炎の治療に関する抗菌薬の研究 antibiotic studies for the treatment of community acquired pneumonia in adults
• 3. 小児における急性中耳炎：治療 acute otitis media in children treatment
• 4. メチシリン耐性黄色ブドウ球菌およびバンコマイシン耐性腸球菌の治療のための抗菌薬の薬理学 pharmacology of antimicrobial agents for treatment of methicillin resistant staphylococcus aureus and vancomycin resistant enterococcus

English Journal

• Prevalence of antimicrobial resistant Streptococcus pneumoniae serotype 11A isolates in Korea, during 2004-2013, due to the increase of multidrug-resistant clone, CC166.

• Baek JY1, Kim SH1, Kang CI2, Chung DR3, Peck KR2, Ko KS4, Song JH5.
• Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.Infect Genet Evol.2016 Mar;38:122-5. doi: 10.1016/j.meegid.2015.12.018. Epub 2015 Dec 28.
• Since the introduction of the pneumococcal conjugate vaccine (PCV7) in Korea in 2003, the proportion of non-vaccine serotypes has increased. Among non-vaccine serotypes, serotype 11A is highly prevalent in Korea. We investigated the prevalence and characteristics of Streptococcus pneumoniae serotype
• PMID 26733441

• The impact of heptavalent pneumococcal conjugate vaccine on the incidence of childhood community-acquired pneumonia and bacteriologically confirmed pneumococcal pneumonia in Japan.

• Naito S1, Tanaka J1, Nagashima K2, Chang B3, Hishiki H1, Takahashi Y1, Oikawa J1, Nagasawa K1, Shimojo N1, Ishiwada N4.
• Epidemiology and infection.Epidemiol Infect.2016 Feb;144(3):494-506. doi: 10.1017/S0950268815001272. Epub 2015 Jun 30.
• Heptavalent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2010. We investigated the impact of PCV7 on childhood community-acquired pneumonia (CAP) and pneumococcal pneumonia (PP). Children aged <5 years living in Chiba city, Japan, who were admitted to hospitals were enrolled t
• PMID 26122538

• Antimicrobial susceptibility trends among gram-positive and -negative clinical isolates collected between 2005 and 2012 in Mexico: results from the Tigecycline Evaluation and Surveillance Trial.

• Morfin-Otero R1, Noriega ER2, Dowzicky MJ3.
• Annals of clinical microbiology and antimicrobials.Ann Clin Microbiol Antimicrob.2015 Dec 15;14:53. doi: 10.1186/s12941-015-0116-y.
• BACKGROUND: The Tigecycline Evaluation and Surveillance Trial (T.E.S.T) is a global antimicrobial surveillance study of both gram-positive and gram-negative organisms. This report presents data on antimicrobial susceptibility among organisms collected in Mexico between 2005 and 2012 as part of T.E.S
• PMID 26667651

Japanese Journal

• 介護施設入所の高齢者肺炎例から分離されたMeropenem耐性を含む多剤耐性肺炎球菌の遺伝子学的解析

• 太田 和子,千葉 菜穂子,佐藤 謙太郎 [他]
• 感染症学雑誌 = The journal of Japanese the Association for Infectious Diseases 88(4), 444-451, 2014-07
• NAID 40020184926

• Clinical Characteristics of Nursing and Healthcare-Associated Pneumonia: A Japanese Variant of Healthcare-Associated Pneumonia

• , , , , ,
• Internal Medicine 51(18), 2537-2544, 2012
• … Streptococcus pneumoniae was the leading pathogen in both groups, whereas the frequency of multidrug-resistant pathogens was higher in the NHCAP patients. …
• NAID 130002062394

• Trends in Antimicrobial Susceptibility of Streptococcus pneumoniae in the Tohoku District of Japan: A Longitudinal Analysis from 1998 to 2007

• , , , , , , , , , , , , , , , , ,
• The Tohoku Journal of Experimental Medicine 220(1), 47-57, 2010
• … Streptococcus pneumoniae is a common cause of respiratory tract infections (RTIs). … The prevalence of Streptococcus pneumoniae strains with reduced susceptibility to antimicrobial agents has dramatically increased worldwide. …
• NAID 130004822220

---

★リンクテーブル★

リンク元	「多剤耐性肺炎球菌」
関連記事	「Streptococcus pneumoniae」「resistant」「pneumoniae」「multidrug」

「多剤耐性肺炎球菌」

　　[★]

英

multidrug-resistant Streptococcus pneumoniae

関

Streptococcus pneumoniae、多剤耐性菌

「Streptococcus pneumoniae」

　　[★]

ラ

Streptococcus pneumoniae

同

肺炎球菌、肺炎レンサ球菌、肺炎連鎖球菌、肺炎双球菌、ストレプトコッカス・ニューモニエ

関

連鎖球菌

• first aid step1 2006 p.134,138

細菌学

• グラム陽性球菌
• 西洋槍(ランセット)型の双球菌
• α溶血性。ランスフィールド分類には分類されない
• オプトヒン感受性
• 自己融解 autolysis ←　培養しすぎに注意
• 中心部の陥凹した集落
• 莢膜多糖体を有する　←　抗食菌作用(C3bの付着に抵抗する)
• IgA proteaseを分泌
• 健常人の5-250%の気道に存在するが莢膜がない弱毒の株

感染症

• 肺炎球菌感染症

• 肺炎(大葉性肺炎)

• 慢性気道感染症の急性増悪

• 中耳炎、心内膜炎、関節炎、腹膜炎、軟部組織の炎症(SMB.248)
• 髄膜炎(化膿性髄膜炎)
• 敗血症：sickle cell anemia, splenectomy

易感染性宿主

• 2歳以下の乳幼児や老人で重症化しやすい
• 脾臓を受けた患者、急性骨髄性白血病、骨髄移植、HIV感染症で発症しやすい

most common cause of:

MOPS are Most OPtochin Sensitive

• meningitis 髄膜炎
• otitis media 中耳炎
• pneumonia 肺炎
• sinusitis 副鼻腔炎

診断

• 臨床像から疑い、胸部X線、喀痰のグラム染色、尿中抗原を行う。グラム染色と尿中抗原が陽性であれば特異的な治療を開始する。 (IRE.1010)
• (経験的治療の前に？)診断及び感受性検査のために喀痰培養、血液培養検査を行う。

参考

• 光顕像

• http://www.fujita-hu.ac.jp/~kimigaai/byouri/syourei/syourei21.htm
• http://www.kamimutsukawa.com/vaccine.html
• http://fp-the-ambiguous.blogspot.com/2008/02/blog-post.html

USMLE

• Q book p.192 29

「resistant」

　　[★]

• adj.

• 抵抗性の、耐性の、抵抗する

関

recalcitrance、refractory、resist、resistance、resistive、stand、tolerance、tolerant、withstand

　 　

「pneumoniae」

　　[★] Streptococcus pneumoniae、Klebsiella pneumoniae、Mycoplasma pneumoniae、Chlamydia pneumoniae、Chlamydophila pneumoniae

「multidrug」

　　[★]

• 多剤の、多種薬剤の

関

multiagent、multiple drug、polydrug