moxifloxacin

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モキシフロキサシン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/01 03:28:59」(JST)

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英文文献

  • Effect of fluoroquinolones on mitochondrial function in pancreatic beta cells.
  • Ghaly H1, Jörns A2, Rustenbeck I3.Author information 1Institute of Pharmacology and Toxicology, University of Braunschweig, D-38106 Braunschweig, Germany.2Institute of Clinical Biochemistry, Hannover Medical School, 30623 Hannover, Germany.3Institute of Pharmacology and Toxicology, University of Braunschweig, D-38106 Braunschweig, Germany. Electronic address: i.rustenbeck@tu-bs.de.AbstractHyper- and hypoglycaemias are known side effects of fluoroquinolone antibiotics, resulting in a number of fatalities. Fluoroquinolone-induced hypoglycaemias are due to stimulated insulin release by the inhibition of the KATP channel activity of the beta cell. Recently, it was found that fluoroquinolones were much less effective on metabolically intact beta cells than on open cell preparations. Thus the intracellular effects of gatifloxacin, moxifloxacin and ciprofloxacin were investigated by measuring NAD(P)H- and FAD-autofluorescence, the mitochondrial membrane potential, and the adenine nucleotide content of isolated pancreatic islets and beta cells. 100μM of moxifloxacin abolished the NAD(P)H increase elicited by 20mM glucose, while gatifloxacin diminished it and ciprofloxacin had no significant effect. This pattern was also seen with islets from SUR1 Ko mice, which have no functional KATP channels. Moxifloxacin also diminished the glucose-induced decrease of FAD-fluorescence, which reflects the intramitochondrial production of reducing equivalents. Moxifloxacin, but not ciprofloxacin or gatifloxacin significantly reduced the effect of 20mM glucose on the ATP/ADP ratio. The mitochondrial hyperpolarization caused by 20mM glucose was partially antagonized by moxifloxacin, but not by ciprofloxacin or gatifloxacin. Ultrastructural analyses after 20h tissue culture showed that all three compounds (at 10 and 100μM) diminished the number of insulin secretory granules and that gatifloxacin and ciprofloxacin, but not moxifloxacin induced fission/fusion configurations of the beta cell mitochondria. In conclusion, fluoroquinolones affect the function of the mitochondria in pancreatic beta cells which may diminish the insulinotropic effect of KATP channel closure and contribute to the hyperglycaemic episodes.
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Feb 14;52:206-14. doi: 10.1016/j.ejps.2013.11.011. Epub 2013 Nov 24.
  • Hyper- and hypoglycaemias are known side effects of fluoroquinolone antibiotics, resulting in a number of fatalities. Fluoroquinolone-induced hypoglycaemias are due to stimulated insulin release by the inhibition of the KATP channel activity of the beta cell. Recently, it was found that fluoroquinol
  • PMID 24284031
  • Comparison of automated measurements of electrocardiographic intervals and durations by computer-based algorithms of digital electrocardiographs.
  • Kligfield P1, Badilini F2, Rowlandson I3, Xue J3, Clark E4, Devine B4, Macfarlane P4, de Bie J5, Mortara D5, Babaeizadeh S6, Gregg R6, Helfenbein ED6, Green CL7.Author information 1Division of Cardiology, Weill Cornell Medical College, New York, NY. Electronic address: pkligfi@med.cornell.edu.2AMPS-LLC, New York, NY.3GE Healthcare, Milwaukee, WI.4Glasgow Program, University of Glasgow, Glasgow, United Kingdom.5Mortara Instrument, Milwaukee, WI.6Philips Healthcare, Andover, MA.7Duke Clinical Research Institute, Duke University Medical Center, Durham, NC.AbstractBACKGROUND AND PURPOSE: Automated measurements of electrocardiographic (ECG) intervals are widely used by clinicians for individual patient diagnosis and by investigators in population studies. We examined whether clinically significant systematic differences exist in ECG intervals measured by current generation digital electrocardiographs from different manufacturers and whether differences, if present, are dependent on the degree of abnormality of the selected ECGs.
  • American heart journal.Am Heart J.2014 Feb;167(2):150-159.e1. doi: 10.1016/j.ahj.2013.10.004. Epub 2013 Oct 17.
  • BACKGROUND AND PURPOSE: Automated measurements of electrocardiographic (ECG) intervals are widely used by clinicians for individual patient diagnosis and by investigators in population studies. We examined whether clinically significant systematic differences exist in ECG intervals measured by curre
  • PMID 24439975
  • The Steroids for Corneal Ulcers Trial (SCUT): Secondary 12-Month Clinical Outcomes of a Randomized Controlled Trial.
  • Srinivasan M1, Mascarenhas J1, Rajaraman R2, Ravindran M3, Lalitha P1, O'Brien KS4, Glidden DV5, Ray KJ4, Oldenburg CE4, Zegans ME6, Whitcher JP4, McLeod SD7, Porco TC8, Lietman TM9, Acharya NR10; Steroids for Corneal Ulcers Trial Group.Author information 1Aravind Eye Care System, Madurai, India.2Aravind Eye Care System, Coimbatore, India.3Aravind Eye Care System, Tirunelveli, India.4Francis I. Proctor Foundation, University of California, San Francisco, California.5Department of Epidemiology and Biostatistics, University of California, San Francisco, California.6Departments of Surgery (Ophthalmology) and Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire.7Francis I. Proctor Foundation, University of California, San Francisco, California; Department of Ophthalmology, University of California, San Francisco, California.8Francis I. Proctor Foundation, University of California, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, California.9Francis I. Proctor Foundation, University of California, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, California; Department of Ophthalmology, University of California, San Francisco, California.10Francis I. Proctor Foundation, University of California, San Francisco, California; Department of Ophthalmology, University of California, San Francisco, California. Electronic address: nisha.acharya@ucsf.edu.AbstractPURPOSE: To determine whether topical corticosteroids as adjunctive therapy for bacterial keratitis improves long-term clinical outcomes.
  • American journal of ophthalmology.Am J Ophthalmol.2014 Feb;157(2):327-333.e3. doi: 10.1016/j.ajo.2013.09.025. Epub 2013 Oct 1.
  • PURPOSE: To determine whether topical corticosteroids as adjunctive therapy for bacterial keratitis improves long-term clinical outcomes.DESIGN: Randomized, placebo-controlled, double-masked clinical trial.METHODS: This multicenter trial compared 1.0% prednisolone sodium phosphate to placebo in the
  • PMID 24315294

和文文献

  • モキシフロキサシン添加灌流液を用いた白内障手術の安全性 (特集 第68回日本臨床眼科学会講演集(2))
  • Effect of moxifloxacin on survival, lipid peroxidation and inflammation in immunosuppressed rats with soft tissue infection caused by Stenotrophomonas maltophilia
  • ニューキノロン系抗菌剤による即時型アレルギーの3例:―交差反応についての検討―

関連リンク

Moxifloxacin [MFLX] モキシフロキサシン, ニューキノロン系 1. 商品名 先発品 アベロックス錠400mg 【バイエル薬品】 2. 日本における発売年 2005(平成17)年 3. 特長 呼吸器感染症において1日1回投与で高い臨床効果を示す 高い血中 ...
Generic equivalents In 2007, the U.S. District Court for the District of Delaware held that two Bayer patents on Avelox (moxifloxacin hydrochloride) are valid and enforceable, and infringed by Dr. Reddy's ANDA for a generic version of ...

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