関: mosapramine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/28 14:31:17」(JST)

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Mosapramine (Cremin) is an atypical antipsychotic used in Japan.^[1] It is a potent dopamine antagonist with high affinity to the D₂, D₃, and D₄ receptors,^[2] and with moderate affinity for the 5-HT₂ receptors.^[3]

References

^ Takahashi N, Terao T, Oga T, Okada M. Comparison of risperidone and mosapramine addition to neuroleptic treatment in chronic schizophrenia. Neuropsychobiology. 1999;39(2):81-5. PMID 10072664
^ Futamura T, Ohashi Y, Yano K, Takahashi Y, Haga K, Fukuda T. The affinities of mosapramine for the dopamine receptor subtypes in human cell lines expressing D2, D3 and D4 receptors. Nippon Yakurigaku Zasshi. (Japanese) 1996 May;107(5):247-53. PMID 8690306
^ Sumiyoshi T, Suzuki K, Sakamoto H, Yamaguchi N, Mori H, Shiba K, Yokogawa K. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64. doi:10.1016/0893-133X(94)00064-7 PMID 7766287

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English Journal

Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.

Oka T, Hamamura T, Lee Y, Miyata S, Habara T, Endo S, Taoka H, Kuroda S.SourceDepartment of Neuropsychiatry, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. toka@md.okayama-u.ac.jp
Life sciences.Life Sci.2004 Nov 26;76(2):225-37.
Acute administration of typical and atypical antipsychotics has been reported to induce regionally distinct patterns of c-Fos expression in the rat forebrain. Furthermore, atypical index, the difference in the extent of increased Fos-like immunoreactivity (Fos-LI) in the nucleus accumbens (NAc) shel
PMID 15519367

Perospirone.

Onrust SV, McClellan K.SourceAdis International Limited, Mairangi Bay, Auckland, New Zealand.
CNS drugs.CNS Drugs.2001;15(4):329-37; discussion 338.
Perospirone is an atypical antipsychotic agent for the treatment of schizophrenia. Its primary mode of action is through antagonism of serotonin 5-HT2A and dopamine D2 receptors. An 8-week course of oral perospirone 8 to 48 mg/day displayed efficacy in up to 75% of patients with schizophrenia partic
PMID 11463136

Japanese Journal

セロトニン2・ドーパミン2受容体拮抗薬(SDA)塩酸perospironeの精神分裂病に対する臨床評価 : 塩酸mosapramineを対照薬とした第III相試験

工藤義雄
臨床評価 24, 207-248, 1997
NAID 80009640719

モサプラミンのドパミン受容体サブタイプヘの親和性-ヒトのドパミンD2,D3およびD4受容体発現細胞を用いた評価-

二村隆史,大橋良孝,矢野和宏,高橋有紀子,芳賀慶一郎,福田武美
日本薬理学雑誌 107(5), 247-253, 1996-05-01
Iminodibenzy1系抗精神病薬である塩酸モサプラミンのドパミンD2，D3およびD4受容体に対する親和性を，ヒトの同受容体を発現させた細胞を用いて各種抗精神病薬と比較検討した．ヒト受容体発現細胞から調製したP2画分を用いた場合の[<SUP>3</SUP>H]スピペロンの結合は，いずれの受容体に対しても飽和性を示し，スキャッチャード解析から算出された各受容体に対する親和 …
NAID 10006061364

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★リンクテーブル★

リンク元	「モサプラミン」
拡張検索	「mosapramine hydrochloride」

「モサプラミン」

Mosapramine
Systematic (IUPAC) name
	1'-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	89419-40-9
ATC code	N05AX10
PubChem	CID 4257
ChemSpider	4107
UNII	04UZQ7O9SJ
KEGG	D08235
Chemical data
Formula	C28H35ClN4O
Mol. mass	479.057 g/mol
	SMILES C1CCN2C(C1)NC(=O)C23CCN(CC3)CCCN4C5=CC=CC=C5CCC6=C4C=C(C=C6)Cl;
	InChI InChI=1S/C28H35ClN4O/c29-23-12-11-22-10-9-21-6-1-2-7-24(21)32(25(22)20-23)16-5-15-31-18-13-28(14-19-31)27(34)30-26-8-3-4-17-33(26)28/h1-2,6-7,11-12,20,26H,3-5,8-10,13-19H2,(H,30,34); Key:PXUIZULXJVRBPC-UHFFFAOYSA-N ;
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