monoclonal gammopathies

出典: meddic


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  • Current Controversies in the Management of Myeloma Bone Disease.
  • Silbermann R1, Roodman GD1,2.
  • Journal of cellular physiology.J Cell Physiol.2016 Nov;231(11):2374-9. doi: 10.1002/jcp.25351. Epub 2016 Mar 10.
  • Recent significant advances in the treatment of multiple myeloma have resulted in an improvement in median overall survival from 4.6 years, for patients diagnosed between 2001 and 2005, to 6.1 years, for those diagnosed between 2006 and 2010 (Kumar et al., 2014). However, myeloma bone lesions persis
  • PMID 26910829
  • Benefits of new immunoglobulin-derived biomarkers for the diagnosis and follow-up of patients with dysglobulinemia.
  • Ermak N1, Nguyen-Khoa T1, Alyanakian MA2.
  • Annales de biologie clinique.Ann Biol Clin (Paris).2016 Oct 1;74(5):597-605.
  • The diagnostics and follow-up of monoclonal gammopathies such as multiple myeloma require precise analysis of the monoclonal component as well as the other immunoglobulins isotypes, which might be limited by the sensitivity of standard laboratory methods. New serum biomarkers were developed for rout
  • PMID 27707674
  • Screening Method for M-Proteins in Serum Using Nanobody Enrichment Coupled to MALDI-TOF Mass Spectrometry.
  • Kohlhagen MC1, Barnidge DR1, Mills JR1, Stoner J1, Gurtner KM1, Liptac AM1, Lofgren DI1, Vanderboom PM2, Dispenzieri A3, Katzmann JA1, Willrich MA1, Snyder MR1, Murray DL4.
  • Clinical chemistry.Clin Chem.2016 Oct;62(10):1345-52. doi: 10.1373/clinchem.2015.253781. Epub 2016 Aug 11.
  • BACKGROUND: Current recommendations for screening for monoclonal gammopathies include serum protein electrophoresis (PEL), imunofixation electrophoresis (IFE), and free light chain (FLC) ratios to identify or rule out an M-protein. The aim of this study was to examine the feasibility of an assay bas
  • PMID 27515443


  • CMTと炎症性ニューロパチー (特集 シャルコー・マリー・トゥース病)
  • Brain and nerve : 神経研究の進歩 68(1), 31-42, 2016-01
  • NAID 40020711432
  • Clinical, electrophysiological and immunological study of peripheral nerves in Egyptian patients with monoclonal gammopathies
  • 単クローン性γグロブリン血症における血清遊離軽鎖測定の臨床的有用性


Symptoms of monoclonal gammopathies differ among these conditions, but can include: Anemia, or low red blood cells counts Fatigue, or tiredness Weakness Pain in the bones or soft tissues Tingling or numbness in the feet or ...
... monitoring and risk stratification of the monoclonal gammopathies which range in severity from the usually benign monoclonal gammopathy of undetermined significance (MGUS) to the incurable multiple myeloma (MM) and ...






monoclonal gammopathy MG
単クローン性高免疫グロブリン血症 monoclonal hyperimmunoglobulinemia単クローン性高ガンマグロブリン血症 単クローン性高γグロブリン血症 monoclonal hypergammaglobulinemiaM蛋白血症 M proteinemia
  • 080626 免疫学

Clasification WCH.2566

  • monoclonal gammopathy of undetermined significance
  • benign(IgG, IgA, IgD, IgM, and, rarely, free light chains)
  • associated with neoplasms of cell types not known to produce M-proteins
  • biclonal gammopathy
  • idiopathic Nence Jones proteinuria
  • malignant monoclonal gammopathies
  • overt multiple myeloma
  • smoldering multiple myeloma
  • plasma cell leukemia
  • nonsecretory myeloma
  • IgD myeloma
  • POEMS: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (osteosclerotic myeloma)
  • solitary plsmacytoma of bone
  • extramedullary plamacytoma
  • malignant lymphoproliferative disorders
  • heavy chain diseases
  • γ heary chain disease
  • α heary chain disease
  • μ heary chain disease
  • amyloidosis
  • primary amyloidosis
  • with multiple myeloma (secondary, localized, and familial amyloidosis with no M-protein)

frequency WCH.2567

  • monoclonal gammopathy of underteermined significance: 62%
  • multiple myeloma: 16%
  • amyloidosis: 8%
  • lymphoproliferative: 3%
  • smoldering multiple myeloma: 4%
  • solitary or extramedullary: 1%
  • Walderstrom maroglobulinemia: 3%
  • other: 3%



  • adj.

WordNet   license wordnet

「forming or derived from a single clone」