mitochondrial disorders

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/21 15:23:36」(JST)

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  • A Mitochondrial DNA A8701G Mutation Associated with Maternally Inherited Hypertension and Dilated Cardiomyopathy in a Chinese Pedigree of a Consanguineous Marriage.
  • Zhu Y, Gu X1, Xu C.
  • Chinese medical journal.Chin Med J (Engl).2016 5th Feb;129(3):259-266. doi: 10.4103/0366-6999.174491.
  • BACKGROUND: Cardiovascular diseases, including dilated cardiomyopathy (DCM) and hypertension, are the leading cause of death worldwide. The role of mitochondrial DNA (mtDNA) in the pathogenesis of these diseases has not been completely clarified. In this study, we evaluate whether A8701G mutation is
  • PMID 26831225
  • Mg(++) requirement for MtHK binding, and Mg(++) stabilization of mitochondrial membranes via activation of MtHK & MtCK and promotion of mitochondrial permeability transition pore closure: A hypothesis on mechanisms underlying Mg(++)'s antioxidant and cytoprotective effects.
  • Golshani-Hebroni S.
  • Gene.Gene.2016 Apr 25;581(1):1-13. doi: 10.1016/j.gene.2015.12.046. Epub 2015 Dec 28.
  • Evidence points to magnesium's antioxidant, anti-necrotic, and anti-apoptotic effects in cardio- and neuroprotection. With magnesium being involved in over 300 biochemical reactions, the mechanisms underlying its cytoprotective and antioxidant effects have remained elusive. The profound anti-apoptot
  • PMID 26732303


  • G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice
  • Shimizu Akinori,Mito Takayuki,Hashizume Osamu,Yonekawa Hiromichi,Ishikawa Kaori,Nakada Kazuto,Hayashi Jun-Ichi
  • Biochemical and biophysical research communications 459(1), 66-70, 2015-03
  • … We previously generated mito-mice-tRNALys7731 as a model for primary prevention of mitochondrial diseases. … Unlike young mito-mice-tRNALys7731, aged mito-mice-tRNALys7731 developed muscle atrophy, renal failures, and various metabolic abnormalities, such as lactic acidosis and anemia, characteristic of patients with mitochondrial diseases. …
  • NAID 120005608167
  • Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders
  • Mito Takayuki,Ishizaki Hikari,Suzuki Michiko,Morishima Hitomi,Ota Azusa,Ishikawa Kaori,Nakada Kazuto,Maeno Akiteru,Shiroishi Toshihiko,Hayashi Jun-Ichi
  • Biochemical and biophysical research communications 456(4), 933-937, 2015-01
  • … The spectra of phenotypes associated with aging and mitochondrial diseases sometimes appear to overlap with each other. … We used aged mice and a mouse model of mitochondrial diseases (transmitochondrial mito-miceΔ with deleted mtDNA) to study whether premature aging phenotypes observed in mtDNA mutator mice are associated with aging or mitochondrial diseases. …
  • NAID 120005555603


NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. Pagon RA, Adam MP, Bird TD, et al., editors. GeneReviews [Internet]. ... Summary Disease characteristics. Mitochondrial diseases are a ...
Mitochondrial disorders Definition Mitochondrial disorders, also called mitochondrial cytopathies, are a diverse group of diseases caused by damage to small structures found in human cells that are essential in converting food to ...






  • 障害:個人的苦痛や機能の障害があるので「疾病」とは言えるものの、その背景にある臓器障害がもう一つはっきりしない場合に用いられる。(PSY.9)
  • n.
  • an untidy state; a lack of order or organization (⇔order)
  • violent behaviour of large groups of people
  • an illness that cause a part of the body to stop functioning correctly
  • 注意
disease <> illness <> disorder
  • vt.
  • 乱す、乱雑にする。(人)の(心身の)調子を狂わせる。
  • vi.

WordNet   license wordnet

「bring disorder to」

WordNet   license wordnet

「a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time"」

WordNet   license wordnet

「a disturbance of the peace or of public order」

PrepTutorEJDIC   license prepejdic

「〈U〉『無秩序』,混乱,乱雑(confusion) / 《しばしば複数形で》(社会的・政治的な)粉争,騒動 / 〈C〉(肉体的・精神的な)不調,異常,障害 / …‘の'秩序を乱す / 〈心身〉‘に'異常を起こさせる」



  • adj.
  • ミトコンドリアの