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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/03/17 15:27:05」(JST)

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  • Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma.
  • Fernandes-Rosa FL1, Williams TA1, Riester A1, Steichen O1, Beuschlein F1, Boulkroun S1, Strom TM1, Monticone S1, Amar L1, Meatchi T1, Mantero F1, Cicala MV1, Quinkler M1, Fallo F1, Allolio B1, Bernini G1, Maccario M1, Giacchetti G1, Jeunemaitre X1, Mulatero P1, Reincke M1, Zennaro MC2.
  • Hypertension.Hypertension.2014 Aug;64(2):354-61. doi: 10.1161/HYPERTENSIONAHA.114.03419. Epub 2014 May 27.
  • Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs). Our aim was to investigate the prevalence of somatic mutations in these genes in unselected patients with APA
  • PMID 24866132
  • Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate.
  • Kim W1, Jones JO2, Diamond M3, Haqq C4, Molina A5, Small EJ1, Ryan CJ1.
  • Prostate cancer and prostatic diseases.Prostate Cancer Prostatic Dis.2014 Jul 22. doi: 10.1038/pcan.2014.27. [Epub ahead of print]
  • Background:Abiraterone acetate (AA), a highly potent CYP17A1 inhibitor, has demonstrated marked clinical benefit in patients with metastatic castration-resistant prostate cancer (CRPC). Phase I trials of AA without prednisone showed significant elevation of serum mineralocorticoid concentrations. Th
  • PMID 25047002
  • Addison's Disease and Pituitary Enlargement.
  • Winters SJ1, Vitaz T, Nowacki MR, Craddock DC, Silverman C.
  • The American journal of the medical sciences.Am J Med Sci.2014 Jul 7. [Epub ahead of print]
  • : A 60-year-old man with Addison's disease, primary hypothyroidism and type 2 diabetes mellitus who was treated with stable doses of hydrocortisone and fludrocortisone developed increasing skin pigmentation and a bitemporal hemianopia. The plasma ACTH level was 14,464 pg/mL, and an invasive pituitar
  • PMID 25004119


  • Blood Pressure Variability Activates Cardiac Mineralocorticoid Receptor and Induces Cardiac Remodeling in Hypertensive Rats
  • YASUOKA Suguru,KAI Hisashi,KAJIMOTO Hidemi,KUDO Hiroshi,TAKAYAMA Narimasa,ANEGAWA Takahiro,KOGA Mitsuhisa,MIYAMOTO Takanobu,MIFUNE Hiroharu,KAGE Masayoshi,HIROOKA Yoshitaka,IMAIZUMI Tsutomu
  • Circulation journal : official journal of the Japanese Circulation Society 77(6), 1474-1481, 2013-05-25
  • NAID 10031158877
  • Molecular cloning and characterization of the corticoid receptors from the American alligator
  • Oka Kaori,Kohno Satomi,Urushitani Hiroshi,Guillette Louis J. Jr.,Ohta Yasuhiko,Iguchi Taisen,Katsu Yoshinao
  • Molecular and Cellular Endocrinology 365(2), 153-161, 2013-01-30
  • … Although extensively studied in mammals and some non-mammalian species, the molecular mechanisms of corticosteroid hormone (glucocorticoids and mineralocorticoids) action are poorly understood in reptiles. …
  • NAID 120005228364
  • Blood Pressure Variability Activates Cardiac Mineralocorticoid Receptor and Induces Cardiac Remodeling in Hypertensive Rats
  • Yasuoka Suguru,Kai Hisashi,Kajimoto Hidemi,Kudo Hiroshi,Takayama Narimasa,Anegawa Takahiro,Koga Mitsuhisa,Miyamoto Takanobu,Mifune Hiroharu,Kage Masayoshi,Hirooka Yoshitaka,Imaizumi Tsutomu
  • Circulation Journal 77(6), 1474-1481, 2013
  • Background: Hypertensive patients with large blood pressure variability (BPV) have aggravated target organ damage. Because the aldosterone/mineralocorticoid receptor (MR) system is a possible mechanis …
  • NAID 130003361669


mineralocorticoids (min´əral´ōkôr´tikoidz), n.pl (proinflammatory hormones), adrenal corticosteroids that are active in the retention of salt and in the maintenance of life of adrenalectomized animals. Typical are deoxycorticosterone and ...
... and can largely be prevented by replacement of salts and mineralocorticoids. Clearly mineralocorticoids are acutely critical for maintenance of life! Aldosterone and Mineralocorticoid Receptors The principal steroid with ...


secrete 1 outer zone mineralocorticoids CHRONIC ADRENOCORTICAL INSUFFICIENCY. too many mineralocorticoids in the bloodTreating Dogs with Hypoadrenocorticism Changes in pituitary function with ageing  to measure levels of mineralocorticoids




mineral corticoid MC, mineralocorticoid
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  • 副腎皮質で産生・分泌され、電解質代謝に関与する。




  • ステロイド


  • 副腎皮質球状層の細胞(主に)



  • 腎集合管、唾液腺、乳腺、汗腺などに働いてNa+の再吸収を促進し、K+の排出(分泌)を促進する
  • 腎集合管でH+の排出(分泌)を促進する  →  血中HCO3-濃度上昇


  • アンジオテンシンIIが副腎皮質球状層細胞に作用してアルドステロンの分泌合成を促す (SP.899)
  • レニン-アンジオテンシン-アルドステロン系の最後のホルモン


  [★] 鉱質コルチコイド

WordNet   license wordnet

「hormone that is one of the steroids of the adrenal cortex that influences the metabolism of sodium and potassium」