WordNet
- be a student; follow a course of study; be enrolled at an institute of learning
- a room used for reading and writing and studying; "he knocked lightly on the closed door of the study"
- applying the mind to learning and understanding a subject (especially by reading); "mastering a second language requires a lot of work"; "no schools offer graduate study in interior design" (同)work
- a composition intended to develop one aspect of the performers technique; "a study in spiccato bowing"
- a state of deep mental absorption; "she is in a deep study"
- someone who memorizes quickly and easily (as the lines for a part in a play); "he is a quick study"
- give careful consideration to; "consider the possibility of moving" (同)consider
- learn by reading books; "He is studying geology in his room"; "I have an exam next week; I must hit the books now" (同)hit the books
- think intently and at length, as for spiritual purposes; "He is meditating in his study" (同)meditate, contemplate
- provide with or construct with studs; "stud the wall"
- ornament consisting of a circular rounded protuberance (as on a vault or shield or belt) (同)rivet
- poker in which each player receives hole cards and the remainder are dealt face up; bets are placed after each card is dealt (同)stud poker
- adult male horse kept for breeding (同)studhorse
- a man who is virile and sexually active (同)he-man, macho-man
PrepTutorEJDIC
- 〈U〉(一般に)『勉強』,学習すること / 〈C〉(…の)勉強,研究《+of+名》 / 〈C〉〈U〉(…の)『綿密な調査』,検討《+of+名》 / 〈C〉研究対象(問題,事項);学科 / 〈C〉『書斎』,勉強部屋 / 〈C〉(美術・文学などの)習作,試作,スケッチ,(音楽の)練習曲,エチュード / …‘を'『勉強する』,学ぶ,研究する / …‘を'『よく注意して見る』,しげしげと見る / …‘を'『調査する』,検討する / …‘を'考慮する,配慮する / 〈せりふなど〉‘を'覚えようとする / 『勉強する』,学ぶ,研究する
- 《おもに米》種馬 / 《集合的に》(一群の)繁殖用動物(種馬,種牛など)
- (インテリアなどに用いる)飾りびょう / カフスボタン,カラーボタン / (建物の)間柱 / (…を)…‘に'ちりばめる《+名+with+名》 / …‘に'点在(散在)している / …‘に'間柱をつける
UpToDate Contents
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- 1. オフポンプ低浸襲直接的冠動脈バイパス手術：転帰 off pump and minimally invasive direct coronary artery bypass graft surgery outcomes
- 2. 冠動脈疾患の疫学 epidemiology of coronary heart disease
- 3. 急性虚血性脳卒中に対する再灌流療法 reperfusion therapy for acute ischemic stroke
- 4. 成人の非糖尿病性慢性腎臓病患者に対する降圧療法と病状の進展 antihypertensive therapy and progression of nondiabetic chronic kidney disease in adults
- 5. 原発性（本態性）高血圧における治療選択：臨床試験 choice of therapy in primary essential hypertension clinical trials
English Journal
- Observational infant exploratory [(14) C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis.
- Garner CR1,2, Park KB3, French NS3, Earnshaw C3, Schipani A3, Selby AM4, Byrne L4, Siner S4, Crawley FP5, Vaes WH6, van Duijn E6, deLigt R6, Varendi H7, Lass J7, Grynkiewicz G8, Maruszak W8, Turner MA9.
- British journal of clinical pharmacology.Br J Clin Pharmacol.2015 Jul;80(1):157-67. doi: 10.1111/bcp.12597. Epub 2015 Jun 1.
- AIMS: The aims of the study were to compare [(14) C]-paracetamol ([(14) C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age grou
- PMID 25619398
- An Assessment of the Oral Bioavailability of Three Ca-Channel Blockers Using a Cassette-Microdose Study: A New Strategy for Streamlining Oral Drug Development.
- Yamashita S1, Kataoka M1, Suzaki Y2, Imai H2, Morimoto T2, Ohashi K2, Inano A3, Togashi K4, Mutaguchi K4, Sugiyama Y5.
- Journal of pharmaceutical sciences.J Pharm Sci.2015 Jun 2. doi: 10.1002/jps.24499. [Epub ahead of print]
- A cassette-microdose (MD) clinical study was performed to demonstrate its usefulness for identifying the most promising compound for oral use. Three Ca-channel blockers (nifedipine, nicardipine, and diltiazem) were chosen as model drugs. In the MD clinical study, a cassette-dose method was employed
- PMID 26037531
- Estradiol and Antagonist Pretreatment Prior to Microdose Leuprolide in in Vitro Fertilization. Does It Improve IVF Outcomes in Poor Responders as Compared to Oral Contraceptive Pill?
- Elassar A, Nulsen J, Engmann L, Benadiva C.
- The Journal of reproductive medicine.J Reprod Med.2015 May-Jun;60(5-6):199-204.
- OBJECTIVE: To compare in vitro fertilization (IVF) outcomes in low responders stimulated with microdose leuprolide protocol (ML) following pretreatment with either oral contraceptive pill (OCP) or luteal estradiol (E2) + GnRH antagonist (E2 + antag) for follicular synchronization prior to controlled
- PMID 26126304
Japanese Journal
- 前臨床段階におけるマイクロドース臨床治験のインパクト
- 金 淳二
- 薬学雑誌. 乙号 134(4), 459-463, 2014
- … A microdose clinical trial may be useful as a safe early-phase exploratory study using doses as low as 100 μg or less for determination of the disposition of a candidate compound in humans in a short period of time. … In this study, we examined microdose trials performed in the preclinical stage for two first-in-class compounds with a new mechanism of action. … For this reason, first-in-human microdose clinical trials were performed. …
- NAID 130003391191
- 超微量投与で最良の医薬品候補を選ぶ創薬におけるマイクロドーズ臨床試験の有用性
- 山浦 由之
- 日本薬理學雜誌 = Folia pharmacologica Japonica 141(3), 126-130, 2013-03-01
- NAID 10031156950
- Quantitation of 14C-Oxaliplatin Concentrations in Human Serum Samples by Using Accelerator Mass Spectrometry
- , , , ,
- RADIOISOTOPES 62(8), 517-523, 2013
- … Accelerator mass spectrometry (AMS) has high detection sensitivity and is expected to play an important role in microdose trials. … In this study, we used the AMS microdosing facility at Yamagata University to measure the concentration of 14C in 14C-oxaliplatin-spiked serum samples. …
- NAID 130004511687
Related Links
- 患者の為の治験・臨床試験ポータルサイト。患者サイドに立って治験及び臨床試験に関する情報を提供。 ... MD試験（マイクロドーズ試験） MD試験（microdose study、microdosing study） マイクロドーズ臨床試験（マイクロドーズ試験）の ...
- This study is a methodology study to evaluate a microdose strategy for Drug-Drug Interaction (DDI) which will be useful in the evaluation of the backup compounds for GSK706769, as well as possibly other assets. The safety ...
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★リンクテーブル★
| リンク元 | 「マイクロドーズ臨床試験」 |
| 関連記事 | 「study」「microdosing」「stud」 |
「マイクロドーズ臨床試験」
「study」
- n.
- 研究、勉学、学習
- (～の)研究、学問。[-ies](従事している)研究、学業(in,on,of,into)
- 慎重な調査、詳細な検討
- 研究対象/研究題目。研究論文、論考。[-ies]学科
- (～に関して)研究に値するもの、見もの、(～の)具体例(in)
- 書斎、勉強部屋、研究室
- vt.
- vi.
- 関
- examine、exploration、explore、inquire、inquiry、investigate、investigation、investigational、investigative、laboratory research、probing、research、scan、surveillance、survey、work
「microdosing」
- n.
- (有効量よりずっと少ない用量の治験薬を用いてヒト体内での代謝や分布を調べる方法)マイクロドージング、マイクロドーズ臨床試験
「stud」
- adj.
- 繁殖用の