WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/25 14:13:44」(JST)

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Metipranolol (OptiPranolol, Betanol, Disorat, Trimepranol) is a non-selective beta blocker used in eye drops to treat glaucoma. It is rapidly metabolized into desacetylmetipranolol.^[1]

References

^ Maffei Facino, R.; Bertuletti, R.; Carini, M.; Tofanetti, O. (1980). "In vitro metabolism of methypranolol by rat liver". Analytical Chemistry Symposia Series 4 (6): 217–223.

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1. 原発性乳児緑内障 primary infantile glaucoma

English Journal

Cost analysis of glaucoma medications: a 3-year review.

Vold SD1, Riggs WL, Jackimiec J.
Journal of glaucoma.J Glaucoma.2002 Aug;11(4):354-8.
PURPOSE: To evaluate yearly cost of glaucoma medications at a university-affiliated teaching hospital with its own health maintenance organization from 1998 through 2000.METHODS: We retrieved data from the Scott and White prescription claims file for 1,484 patients concerning Health Plan glaucoma-me
PMID 12169974

Comparison of the effects of 0.5% timolol maleate, 2% carteolol hydrochloride, and 0.3% metipranolol on intraocular pressure and perimetry findings and evaluation of their ocular and systemic effects.

Mirza GE1, Karaküçük S, Temel E.
Journal of glaucoma.J Glaucoma.2000 Feb;9(1):45-50.
PURPOSE: To compare the effects of 0.5% timolol maleate, 2% carteolol, and 0.3% metipranolol on intraocular pressure (IOP) in 45 patients with primary open-angle glaucoma (POAG) and ocular hypertension. A secondary goal of this study was to evaluate the ocular and systemic side effects of these medi
PMID 10708231

Daily cost of beta-adrenergic blocker therapy.

Stewart WC1, Sine C, Cate E, Minno GE, Hunt HH.
Archives of ophthalmology (Chicago, Ill. : 1960).Arch Ophthalmol.1997 Jul;115(7):853-6.
OBJECTIVE: To evaluate the daily cost of beta-blocker therapy among commercially available products.METHODS: Ten different beta-adrenergic blocker preparations, each in 10-mL bottles (except Timoptic-XE [Merck brand of timolol maleate gel-forming solution], which was in a 5-mL bottle), were acquired
PMID 9230824

「メチプラノロール」

Metipranolol
Systematic (IUPAC) name
	(RS)-4-{[-2-hydroxy-3-(isopropylamino)propyl]oxy}-2,3,6-trimethylphenyl acetate
Clinical data
Trade names	Optipranolol
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601078
Identifiers
CAS Number	22664-55-7
ATC code	S01ED04 (WHO) C07BA68
PubChem	CID 31477
IUPHAR/BPS	7239
DrugBank	DB01214
ChemSpider	29193
UNII	X39AL81KEB
KEGG	D02374
ChEMBL	CHEMBL1291
Chemical data
Formula	C17H27NO4
Molar mass	309.401 g/mol
Chirality	Racemic mixture
	SMILES O=C(Oc1c(c(c(OCC(O)CNC(C)C)cc1C)C)C)C ;
	InChI InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3 ; Key:BQIPXWYNLPYNHW-UHFFFAOYSA-N ;
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