methylene diphosphonate

同

MDP

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/02 07:38:35」(JST)

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Medronic acid
IUPAC name Methanediylbis(phosphonic acid)
Other names Methanediphosphonic acid; Methylenebis(phosphonic acid); Methylene diphosphonate; Medronate; Phosphonomethylphosphonic acid; MDP
Identifiers
CAS number	1984-15-2 N
PubChem	16124
ChemSpider	15308 Y
KEGG	D04887 Y
ChEBI	CHEBI:43945 N
ChEMBL	CHEMBL180570 Y
Jmol-3D images	Image 1
SMILES O=P(O)(O)CP(=O)(O)O
InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) Y Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N Y
Properties
Molecular formula	CH6O6P2
Molar mass	176.00 g mol−1
Melting point	199–200 °C
Hazards
LD50	45-50 mg/kg (i.v., mice, rabbits)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N (verify) (what is: Y/N?)
Infobox references

Not to be confused with mildronate, a clinically used cardioprotective drug that is used for the treatments of angina and myocardial infarction by inhibiting gamma-butyrobetaine dioxygenase.

Medronic acid is the smallest bisphosphonate. Its complex with radioactive technetium, ^99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

References

UpToDate Contents

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• 1. 閉経後女性における骨粗鬆症に対するビスホスホネート投与 the use of bisphosphonates in postmenopausal women with osteoporosis
• 2. 多発性骨髄腫患者のビスフォスフォネート製剤の使用 the use of bisphosphonates in patients with multiple myeloma
• 3. 早期乳癌における骨吸収抑制剤の使用の概要 overview of the use of osteoclast inhibitors in early breast cancer
• 4. 骨粗鬆症患者におけるビスホスホネート療法のリスク risks of bisphosphonate therapy in patients with osteoporosis
• 5. ビスホスホネートの薬理学 pharmacology of bisphosphonates

English Journal

• Diagnostic value of 99mTc-MDP SPECT/spiral CT combined with three-phase bone scintigraphy in assessing suspected bone tumors in patients with no malignant history.

• Zhang Y1, Shi H, Li B, Xiu Y, Cai L, Gu Y, Chen S.
• Nuclear medicine communications.Nucl Med Commun.2015 Jul;36(7):686-94. doi: 10.1097/MNM.0000000000000299.
• INTRODUCTION: Three-phase bone scintigraphy using technetium-99m-methylene diphosphonate is used to diagnose skeletal lesions, whereas single-photon emission computed tomography/computed tomography (SPECT/CT) improves the diagnostic accuracy of bone disease. We investigated the usefulness of SPECT/C
• PMID 25757199

• The role of bone SPECT/CT in the evaluation of painful joint prostheses.

• Arcan P1, Okudan Tekin B, Şefizade R, Naldöken S, Baştuğ A, Özkurt B.
• Nuclear medicine communications.Nucl Med Commun.2015 Jun 5. [Epub ahead of print]
• OBJECTIVE: In this study, we aimed to evaluate the contribution of single-photon emission computerized tomography/computed tomography (SPECT/CT) to three-phase planar bone scintigraphy/SPECT in the assessment of aseptic and septic prosthesis loosening in patients with painful hip and knee prostheses
• PMID 26049374

• Lumbosacral Transitional Vertebra Diagnosed on 99mTc-Methylene Diphosphonate SPECT/CT.

• Kassir MA1, Al-Faham Z2, Abel N2, Balon HR2.
• Journal of nuclear medicine technology.J Nucl Med Technol.2015 Jun;43(2):137-138. Epub 2015 Feb 5.
• Lumbosacral transitional vertebra (LSTV) is a congenital anomaly of the lumbosacral junction. The association between back pain and LSTV is controversial; however, in our patient the symptoms localized to a hemisacralized left transverse process of L5. LSTV should be included in the differential dia
• PMID 25655340

Japanese Journal

• 下顎関節突起を含む下顎骨区域切除術に至った放線菌性骨髄炎の1例

• 日本口腔診断学会雑誌 27(3), 272-278, 2014
• NAID 130004715631

• 骨シンチグラフィ診断支援ソフトウェアにおける空間適応型ノイズ除去処理の有用性

• 日本放射線技術学会雑誌 70(5), 461-466, 2014
• NAID 130004486920

• CZT検出器搭載型小動物用SPECT装置における適切なコリメータの検討

• Annals of Nuclear Medicine 27(3), 271-278, 2013-04
• NAID 120005254012

Related Links

• 99mTc-Methyl diphosphonate - Molecular Imaging and ...

Chemical name: 99m Tc-Methyl diphosphonate Abbreviated name: 99m Tc -MDP Synonym: 99m Tc -Methylene diphosphonate, Technetium 99mTc Medronate Agent Category: Compound Target: Type 2 class of ...

• methylene diphosphonate - Wiktionary

Molecular structure of methylene diphosphonate Noun [] methylene diphosphonate (uncountable) (organic chemistry, oncology) A compound consisting of a methylene bound to two phosphonate groups; in radiology, it is used [] ...

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★リンクテーブル★

リンク元	「MDP」「メチレンジホスホン酸」
拡張検索	「technetium(99mTc) hydroxymethylene diphosphonate」「99mTc-methylene diphosphonate」「technetium(99mTc) methylene diphosphonate」
関連記事	「diphosphonate」

「MDP」

　　[★]

• メチレンジホスホン酸 methylene diphosphonate
• 混合粉じん線維症 mixed-dust pneumoconiosis

「メチレンジホスホン酸」

　　[★]

英

methylene diphosphonate, MDP

関

放射性医薬品

「technetium(99mTc) hydroxymethylene diphosphonate」

　　[★]

関

ヒドロキシメチレンジホスホン酸テクネチウム(99mTc)

「99mTc-methylene diphosphonate」

　　[★] 99mTcメチレンジホスホネート

「technetium(99mTc) methylene diphosphonate」

　　[★] 99mTcメチレンジホスホネート

「diphosphonate」

　　[★] ジホスホン酸、ジホスホン酸塩、ジホスホン酸エステル

関

bisphosphonate