WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/22 14:58:56」(JST)

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Methoxamine is an α₁-adrenergic receptor agonist,^[1] similar in structure to phenylephrine and 2,5-DMA. It was developed by Burroughs-Wellcome in the 1940s.^[2] The drug induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure. Because of its hypertensive effects, it may evoke a compensatory reflex bradycardia via the baroreceptors.

References

^ Pazdernik, Thomas L.; Kerecsen, Laszlo (2007) [2003]. "5". In Goljan, Edward F. Pharmacology (Paperback)|format= requires |url= (help). Rapid Review (Second ed.). Philadelphia, PA: Mosby-Elsevier. p. 39. ISBN 978-0-323-04550-6. |access-date= requires |url= (help)
^ US Patent 2359707 - DIMETHOXYPHENYL beta-HYDROXY ISOPROPYLAMINE

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1. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
2. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
3. 小児における徐脈 bradycardia in children
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5. コーガン症候群 cogans syndrome

English Journal

Estimation of left ventricular stroke volume by impedance cardiography: its relation to the aortic reservoir.

Wang JJ, de Vries G, Tyberg JV.SourceJ.-J. Wang: School of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Road, Xinzhuang District, New Taipie City 24205, Taiwan. 078625@mail.fju.edu.tw.
Experimental physiology.Exp Physiol.2013 Jul;98(7):1213-24. doi: 10.1113/expphysiol.2012.068205. Epub 2013 Mar 28.
Impedance cardiography is a non-invasive technique used to estimate left ventricular (LV) stroke volume (SV) using the change in thoracic impedance (ΔZ). It remains controversial, partly because impedance cardiographic parameters have not been successfully related to haemodynamic events. We hypothe
PMID 23538461

Functional remodeling of arterial endothelium during early postnatal development in rats.

Gaynullina D, Lubomirov LT, Sofronova SI, Kalenchuk VU, Gloe T, Pfitzer G, Tarasova OS, Schubert R.SourceCardiovascular Physiology, Centre for Biomedicine and Medical Technology Mannheim, Ruprecht-Karls-University Heidelberg, 68167 Mannheim, Germany.
Cardiovascular research.Cardiovasc Res.2013 May 31. [Epub ahead of print]
AIMS: Functional remodeling takes place permanently in the circulatory system. Whether this process also affects the anticontractile effect of the endothelium during vasoconstrictor action is unknown. Therefore, the hypothesis was tested that the impact of the anticontractile effect of the endotheli
PMID 23729664

Japanese Journal

Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride

LIU Han,FENG Fang,MA Ming,CUI Shuangjin,XIE Darong,XU Sizhi
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 858(1), 42-48, 2007-10-15
NAID 10025809878

Arterial and Left Ventricular Pressures Illude Transient Alternans of Contractility during Postextrasystolic Potentiation

Iribe G.,Shimizu J.,Mohri S.,Syuu Yi,Imaoka T.,Kiyooka T.,Araki J.,Kanmura Y.,Kajiya F.,Suga H.
The Japanese Journal of Physiology 54(4), 373-383, 2004
… We changed Ea by changing the total peripheral resistance (TPR) with methoxamine hydrochloride (iv) and repeated the measurements. …
NAID 130004921735

冠攣縮性狭心症における圧受容体反射感受性(baroreflex sensitivity)の特徴

松村憲太郎,佐藤清人
日本冠疾患学会雑誌 = Journal of the Japanese Coronary Association 9(3), 134-139, 2003-09-25
NAID 10015747794

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★リンクテーブル★

リンク元	「塩酸メトキサミン」
関連記事	「methoxamine」「hydrochloride」

「塩酸メトキサミン」

Methoxamine
Systematic (IUPAC) name
	2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	390-28-3
ATC code	C01CA10
PubChem	CID 6082
IUPHAR/BPS	483
DrugBank	DB00723
ChemSpider	5857
UNII	HUQ1KC1YLI
KEGG	D08201
ChEMBL	CHEMBL524
Chemical data
Formula	C11H17NO3
Molar mass	211.258
	SMILES O(c1ccc(OC)cc1C(O)C(N)C)C ;
	InChI InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3 ; Key:WJAJPNHVVFWKKL-UHFFFAOYSA-N ;
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