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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/13 00:23:16」(JST)

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Metenolone (or methenolone) is a long-acting anabolic steroid with weak androgenic (testosterone or androsterone-like) properties. It is a naturally occurring drug, found within the adrenal glands of pregnant domesticated felines, and is supplied as the acetate ester for oral administration and as the enanthate ester for intramuscular injection. Adult doses for the treatment of aplastic anemia are usually in a range of 1–3 mg/kg per day.

Side effects[edit]

Adverse side effects include fluid and electrolyte retention, hypercalcaemia, increased bone growth and skeletal weight. In men, additional side priapism, azoospermia, hirsutism, male pattern baldness, acne and oedema. In women, side effects include virilization, amenorrhoea, menstrual irregularities, suppressed lactation, and increased libido. In children, side effects may include premature closure of epiphyses, cessation of linear growth, and virilization symptoms. Metenolone may enhance effects of antidiabetics, ciclosporin, levothyroxine, warfarin. Resistance to the effects of neuromuscular blockers may occur, and metenolone also has the potential to interfere with glucose tolerance and thyroid function tests.

Use in sports[edit]

As an anabolic steroid, the use of metenolone is banned from use in sports governed by the World Anti-Doping Agency.^[1] Belarusian shot putter Nadzeya Ostapchuk was stripped of her gold medal after testing positive for metenolone at the London 2012 Olympic Games.^[2] She has been excluded from future IOC events.

The NBA and NBPA also banned the use of methenolone under the Anti-Drug Program. As of February 2013, Hedo Türkoğlu of the Orlando Magic has been suspended for 20 games without pay by the league after testing positive for methenolone.^[3]

References[edit]

^ "The World Anti-Doping Code: The 2012 Prohibited List". World Anti-Doping Agency. Retrieved 2012-05-10.
^ "IOC withdraws gold medal from shot put athlete Nadzeya Ostapchuk". International Olympic Committee. Retrieved 13 August 2012.
^ "Magic's Hedo Turkoglu suspended 20 games".

English Journal

Myelodysplastic syndrome treated effectively with testosterone enanthate.

Iijima M, Shigehara K, Sugimoto K, Kouji I, Fukushima M, Maeda Y, Konaka H, Mizokami A, Koh E, Namiki M.SourceDepartment of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
International journal of urology : official journal of the Japanese Urological Association.Int J Urol.2011 Jun;18(6):469-71. doi: 10.1111/j.1442-2042.2011.02757.x. Epub 2011 Mar 30.
We report a case of myelodysplastic syndrome (MDS) treated effectively with testosterone enanthate. A 70-year-old man was diagnosed with low-risk MDS in 1998, and he was first given methenolone acetate orally because of gradual progression of anemia and thrombocytopenia. However, this treatment was
PMID 21449972

Development and application of stir bar sorptive extraction with polyurethane foams for the determination of testosterone and methenolone in urine matrices.

Sequeiros RC, Neng NR, Portugal FC, Pinto ML, Pires J, Nogueira JM.SourceUniversity of Lisbon, Faculty of Sciences, Chemistry and Biochemistry Department and Center of Chemistry and Biochemistry, Campo Grande Ed. C8, 1749-016 Lisbon, Portugal.
Journal of chromatographic science.J Chromatogr Sci.2011 Apr;49(4):297-302.
This work describes the development, validation, and application of a novel methodology for the determination of testosterone and methenolone in urine matrices by stir bar sorptive extraction using polyurethane foams [SBSE(PU)] followed by liquid desorption and high-performance liquid chromatography
PMID 21439121

Japanese Journal

高速液体クロマトグラフィーによるウマ血しょう及び尿中フェニルブタゾンとその代謝物の定量(<特集>医薬品の分析)

篠原達美,石高治,田中恒夫,百瀬篤
分析化学 35(3), 278-282, 1986-03-05
ウマ血しょう及び尿中のフェニルフタゾン及び代謝物のオキシフェンブタゾン,γ-ヒドロキシフェニルブタゾンの高速液体クロマトグラフィーによる定量法を検討した.抽出溶媒はジクロルメタン又はベンゼンを使用した.カラムはCosmosil 5C_<18>を用い,移動相は血しょうの場合,アセトニトリル-水-酢酸(55:42:3,v/v),尿では(49:48:3,v/v)を使用し,流速1.0ml/mi …
NAID 110002909329

Androgenの造血促進作用に関する基礎的研究--in vivoにおけるFluoxymesteroneおよびMethenoloneの効果 (Androgenと造血作用<特集>)

堀田知光 [他]
ホルモンと臨床 26(12), p1279-1281, 1978-12
NAID 40003550376

Related Pictures

★リンクテーブル★

リンク元	「メテノロン」「metenolone」

「メテノロン」

Metenolone
Systematic (IUPAC) name
	(5α,17β)-17-Hydroxy-1-methylandrost-1-en-3-one
Clinical data
Trade names	Nibal, Primbolan
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	153-00-4
ATC code	A14AA04
PubChem	CID 3037705
ChemSpider	2301378
UNII	9062ZT8Q5C
Synonyms	17-Hydroxy-1,10,13-trimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
Chemical data
Formula	C20H30O2
Mol. mass	302.451 g/mol
	SMILES O=C2\C=C(\C)[C@@]3([C@H]1CC[C@@]4([C@@H](O)CC[C@H]4[C@@H]1CC[C@H]3C2)C)C;
	InChI InChI=1S/C20H30O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10,13,15-18,22H,4-9,11H2,1-3H3/t13-,15-,16-,17-,18-,19-,20-/m0/s1 ; Key:ANJQEDFWRSLVBR-VHUDCFPWSA-N ;
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