関: methacycline、methacycline hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/21 16:01:53」(JST)

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Metacycline is a tetracycline antibiotic. It is used as a precursour in the industrial synthesis of doxycycline hyclate. It should not be confused with the antibiotic methicillin (aka meticillin).

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English Journal

Antibiotics in the coastal environment of the Hailing Bay region, South China Sea: Spatial distribution, source analysis and ecological risks.

Chen H1, Liu S2, Xu XR3, Zhou GJ2, Liu SS4, Yue WZ2, Sun KF2, Ying GG4.
Marine pollution bulletin.Mar Pollut Bull.2015 Jun 15;95(1):365-73. doi: 10.1016/j.marpolbul.2015.04.025. Epub 2015 Apr 22.
In this study, the occurrence and spatial distribution of 38 antibiotics in surface water and sediment samples of the Hailing Bay region, South China Sea, were investigated. Twenty-one, 16 and 15 of 38 antibiotics were detected with the concentrations ranging from <0.08 (clarithromycin) to 15,163
PMID 25913795

pH-dependent spectroscopy of tetracycline and its analogs.

Mojica ER1, Nguyen E, Rozov M, Bright FV.
Journal of fluorescence.J Fluoresc.2014 Jul;24(4):1183-98. doi: 10.1007/s10895-014-1399-7. Epub 2014 May 9.
Tetracyclines (TCs), broad spectrum antibiotics widely used in the prevention and treatment of infectious diseases, are amphoteric molecules containing several ionizable functional groups that exist predominantly as zwitterions at a given pH value. TCs are reported to undergo a wide variety of react
PMID 24806484

Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline.

Xi Y1, Tan K, Brumwell AN, Chen SC, Kim YH, Kim TJ, Wei Y, Chapman HA.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2014 Jan;50(1):51-60. doi: 10.1165/rcmb.2013-0099OC.
A high-throughput small-molecule screen was conducted to identify inhibitors of epithelial-mesenchymal transition (EMT) that could be used as tool compounds to test the importance of EMT signaling in vivo during fibrogenesis. Transforming growth factor (TGF)-β1-induced fibronectin expression and E-
PMID 23944988

Japanese Journal

Lysozyme-Enhanced Europium(III)-Metacycline Luminescence and Its Application to the Determination of Metacycline

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 21(5), 541-544, 2005-05-10
NAID 10015717745

膿皮症に対するMetacycline Hydrochlorideの臨床的検討

皮膚 7(3), 350-354, 1965-08
NAID 40018447430

膿皮症に対するMetacycline Hydrochlorideの臨床的検討

皮膚 7(3), 350-354, 1965
NAID 130004046207

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★リンクテーブル★

リンク元	「メタサイクリン」「methacycline hydrochloride」

「メタサイクリン」

Metacycline
Systematic (IUPAC) name
	(2Z,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682778
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	J01AA05
PubChem	CID 5281054
ChemSpider	10468596
UNII	IR235I7C5P
ChEMBL	CHEMBL249837
NIAID ChemDB	001301
Chemical data
Formula	C22H22N2O8
Mol. mass	442.419 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-6,10,14-15,17,25,27-29,32H,1H2,2-3H3,(H2,23,31)/t10-,14-,15+,17+,22+/m1/s1 ; Key:MHIGBKBJSQVXNH-IWVLMIASSA-N ;
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