malignant migraine

悪性片頭痛

WordNet

1. dangerous to health; characterized by progressive and uncontrolled growth (especially of a tumor)
2. a severe recurring vascular headache; occurs more frequently in women than men (同)megrim, sick_headache, hemicrania

PrepTutorEJDIC

1. 悪意のある,敵意のある / (病気が)悪性の
2. 偏頭痛

UpToDate Contents

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• 1. 遺伝性出血性毛細血管拡張症（オースラー・ウェーバー・ランデュ症候群） hereditary hemorrhagic telangiectasia osler weber rendu syndrome
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• 4. 癌疼痛のマネージメント：鎮痛補助剤（鎮痛剤） cancer pain management adjuvant analgesics coanalgesics
• 5. 他の病状に影響を与える心理的要因：臨床的特徴、評価、および診断 psychological factors affecting other medical conditions clinical features assessment and diagnosis

English Journal

• Cortical spreading depression in traumatic brain injuries: Is there a role for astrocytes?

• Torrente D1, Cabezas R1, Avila MF1, García-Segura LM2, Barreto GE1, Guedes RC3.Author information 1Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.2Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain.3Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, Brazil. Electronic address: guedes.rca@gmail.com.AbstractCortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.
• Neuroscience letters.Neurosci Lett.2014 Jan 3. pii: S0304-3940(13)01139-7. doi: 10.1016/j.neulet.2013.12.058. [Epub ahead of print]
• Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain
• PMID 24394907

• Opioids in headache.

• Levin M.Author information Department of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.AbstractOpioid analgesics have long been used to treat head pain of various types. This has been increasing to a significant degree over the past 25 years because of a trend for more liberal use of opioids in non-malignant pain. Opioid treatment for acute headache, as well as prophylactically for refractory chronic headache, is controversial. There are a number of adverse effects associated with acute and chronic opioid treatment. Tolerance, dependence, and addiction are prominent issues. This article attempts to analyze the benefits and disadvantages for opioids in the management of migraine and other headache disorders, relying on known properties of this class of medication as well as clinical data. It will mainly focus on 2 topics: the use of opioid medication for the acute treatment of migraine attacks and continuous prophylactic use for refractory chronic migraine.
• Headache.Headache.2014 Jan;54(1):12-21. doi: 10.1111/head.12266.
• Opioid analgesics have long been used to treat head pain of various types. This has been increasing to a significant degree over the past 25 years because of a trend for more liberal use of opioids in non-malignant pain. Opioid treatment for acute headache, as well as prophylactically for refractory
• PMID 24127913

• Neuromodulation for cephalgias.

• Rasskazoff SY1, Slavin KV.Author information 1Insight Institute of Neurosurgery and Neuroscience, Flint, MI, USA.AbstractHeadaches (cephalgias) are a common reason for patients to seek medical care. There are groups of patients with recurrent headache and craniofacial pain presenting with malignant course of their disease that becomes refractory to pharmacotherapy and other medical management options. Neuromodulation can be a viable treatment modality for at least some of these patients. We review the available evidence related to the use of neuromodulation modalities for the treatment of medically refractory craniofacial pain of different nosology based on the International Classification of Headache Disorders, 2(nd) edition (ICHD-II) classification. This article also reviews the scientific rationale of neuromodulation application in management of cephalgias.
• Surgical neurology international.Surg Neurol Int.2013 Apr 17;4(Suppl 3):S136-50. doi: 10.4103/2152-7806.110662. Print 2013.
• Headaches (cephalgias) are a common reason for patients to seek medical care. There are groups of patients with recurrent headache and craniofacial pain presenting with malignant course of their disease that becomes refractory to pharmacotherapy and other medical management options. Neuromodulation
• PMID 23682340

Related Links

• Malignant migraine: the syndrome of prolonged classical ...

1. Funct Neurol. 1986 Oct-Dec;1(4):481-6. Malignant migraine: the syndrome of prolonged classical migraine, epilepsia partialis continua, and repeated strokes; a clinically characteristic disorder probably due to mitochondrial ...

• A case of "malignant" migraine. - National Center for ...

1. Headache. 2003 Jan;43(1):86-7. A case of "malignant" migraine. Parada V, Hamilton WJ, Rothrock JF. PMID: 12864770 [PubMed - indexed for MEDLINE] Publication Types: Case Reports Letter MeSH Terms Brain ...

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関連記事	「malignant」

「malignant」

　　[★]

• adj.

• 悪性の

関

malignantly、pernicious