リンパ管内皮、リンパ内皮
WordNet
- of or relating to or produced by lymph
- an epithelium of mesoblastic origin; a thin layer of flattened cells that lines the inside of some body cavities
PrepTutorEJDIC
- リンパ[液]の / (人が)不活発な,鈍重な
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/02 00:31:40」(JST)
[Wiki en表示]
The lymphatic endothelium is a specialised form of epithelium, distinct from but similar to vascular endothelium. A lymph capillary endothelial cell is distinct from other endothelial cells in that collagen fibers are directly attached to its plasma membrane.
Although lymphatics were first described by Hippocrates in 400BC and rediscovered as "milky veins in the gut of a well fed dog" in the 17th century by Gasparo Aselli, they were ignored for centuries until in 1937 Howard Florey showed that lymphatics enlarge in inflammation. At this stage vascular and lymphatic endothelia were seen to be morphologically distinct and lymphatic vessels considered less important. Later it was discovered that VEGF-R3 and VEGF-C/VEGF-D were the key growth factors controlling lymphatic endothelial proliferation. Markers of lymphatic endolthelium were not discovered until relatively recently. These being LYVE-1 (Jackson et al.,1999)[1] and podoplanin (Kerjaschki,1999).[2]
See also
Endothelium
References
- ^ "J.Cell Biol: LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan 1".
- ^ "Am. J. Pathol: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic andothelium 2".
Further reading
- Jackson DG (2003). "The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1". Trends Cardiovasc. Med. 13 (1): 1–7. doi:10.1016/S1050-1738(02)00189-5. PMID 12554094.
- Banerji S, Ni J, Wang SX et al. (1999). "LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan". J. Cell Biol. 144 (4): 789–801. doi:10.1083/jcb.144.4.789. PMC 2132933. PMID 10037799.
- Cunnick GH, Jiang WG, Gomez KF, Mansel RE (2001). "Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model". Biochem. Biophys. Res. Commun. 288 (4): 1043–1046. doi:10.1006/bbrc.2001.5869. PMID 11689016.
- Mouta Carreira C, Nasser SM, di Tomaso E et al. (2001). "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis". Cancer Res. 61 (22): 8079–84. PMID 11719431.
- Cursiefen C, Schlötzer-Schrehardt U, Küchle M et al. (2002). "Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin". Invest. Ophthalmol. Vis. Sci. 43 (7): 2127–35. PMID 12091407.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Huang SS, Tang FM, Huang YH et al. (2003). "Cloning, expression, characterization, and role in autocrine cell growth of cell surface retention sequence binding protein-1". J. Biol. Chem. 278 (44): 43855–43869. doi:10.1074/jbc.M306411200. PMID 12912978.
- Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nguyen VA, Kutzner H, Fürhapter C et al. (2006). "Infantile hemangioma is a proliferation of LYVE-1-negative blood endothelial cells without lymphatic competence". Mod. Pathol. 19 (2): 291–298. doi:10.1038/modpathol.3800537. PMID 16424896.
- Gu B, Alexander JS, Gu Y et al. (2007). "Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta". Lymphatic research and biology 4 (1): 11–17. doi:10.1089/lrb.2006.4.11. PMC 3072054. PMID 16569201.
- Llovet JM, Chen Y, Wurmbach E et al. (2007). "A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis". Gastroenterology 131 (6): 1758–1767. doi:10.1053/j.gastro.2006.09.014. PMID 17087938.
UpToDate Contents
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English Journal
- The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis.
- Pak KH1, Jo A2,3, Choi HJ4,5, Choi Y6, Kim H7, Cheong JH8,9,10.
- BMC cancer.BMC Cancer.2015 Jul 4;15(1):498.
- BACKGROUND: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to inv
- PMID 26141595
- Topical fentanyl stimulates healing of ischemic wounds in diabetic rats.
- Gupta M1, Poonawala T2, Farooqui M2, Ericson ME3, Gupta K2.
- Journal of diabetes.J Diabetes.2015 Jul;7(4):573-83. doi: 10.1111/1753-0407.12223. Epub 2015 Jan 15.
- BACKGROUND: Topically applied opioids promote angiogenesis and healing of ischemic wounds in rats. We examined if topical fentanyl stimulates wound healing in diabetic rats by stimulating growth-promoting signaling, angiogenesis, lymphangiogenesis and nerve regeneration.METHODS: We used Zucker diabe
- PMID 25266258
- D2-40 negative pyogenic granuloma-like Kaposi's sarcoma: Diagnostic features and histogenetic hypothesis of an uncommon skin tumor in HIV-negative patients.
- Cabibi D1, Giannone AG2, Guarnotta C1, Schillaci O3, Franco V1.
- Pathology, research and practice.Pathol Res Pract.2015 Jul;211(7):528-32. doi: 10.1016/j.prp.2015.03.006. Epub 2015 Apr 2.
- Pyogenic granuloma-like Kaposi's sarcoma (PGLKS) is a recently described skin tumor showing features both of pyogenic granuloma (PG) and Kaposi's sarcoma (KS). The differential diagnosis is often challenging. We reviewed a series of 50 PG and 23 Ks located on distal extremities with the aid of an im
- PMID 25939289
Japanese Journal
- Expression of a monocarboxylate transporter in reticular cells of the mouselymph node and its involvement in the uptake of exogenous particles
- , ,
- Biomedical Research 35(1), 85-90, 2014
- … MCT1-immunoreactive reticular cells also expressed LYVE-1,which is a hyaluronan receptor abundant in both the lymphatic endothelium and hepatic sinusoidalepithelium. …
- NAID 130004903863
- 心嚢を取り囲むように増生した縦隔嚢胞性リンパ管腫の1切除例
- 岡本 圭伍,片岡 瑛子,元石 充,澤井 聡,花岡 淳
- 日本呼吸器外科学会雑誌 28(4), 542-547, 2014
- 症例は62歳，男性．健診で胸部異常陰影を指摘され精査目的に当科を受診した．CT検査で縦隔腫瘍陰影を認め，病変は前上縦隔から心横隔膜角まで，左右方向は心嚢に沿って両側肺門部まで存在していた．経過観察中に，陰影の増大と，安静時胸痛および前胸部絞扼感が出現したため，初診より15ヵ月後に診断，治療目的に手術を施行した．胸骨縦切開で開胸すると，胸腺および周囲脂肪組織内に多房性嚢胞を広範囲に認め，嚢胞内には淡 …
- NAID 130004495404
- 草野 昌男,駒沢 大輔,渡部 敬之,伊藤 広道,土佐 正規,大楽 尚弘,池田 智之,上野 孝治,池谷 伸一,中山 晴夫,樋渡 信夫
- Progress of Digestive Endoscopy 83(1), 146-147, 2013
- … Pathological examination revealed lymphatic spaces separated by a thin septum, lined with flattened endothelium on the ileocecal valve of submucosal tumor, and a mainly well differentiated adenocarcinoma with partially mucinous adenocarcinoma in the ascending colon cancer. …
- NAID 130004652875
Related Links
- The lymphatic endothelium is a specialised form of epithelium, distinct from but similar to vascular endothelium. A lymph capillary endothelial cell is distinct from other endothelial cells in that collagen fibers are directly attached to its plasma ...
- Description, Purified Monoclonal Antibody against Lymphatic Endothelial Marker (Formerly Signet Catalog Nos: 730-001, 730-01, 730-16 L1 Predilute, 730-26 L2 Predilute). Also Known As, podoplanin; T1-alpha; hT1alpha-1; hT1alpha-2; ...
★リンクテーブル★
[★]
- 英
- lymphatic endothelium
- 関
- リンパ管内皮
[★]
- 英
- lymphatic endothelium
- 関
- リンパ内皮
[★]
- 関
- lymph、lymph duct、lymphatic vessel、lymphocytic
[★]
内皮
- 関
- vessel wall