WordNet

(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
relating to or applicable to or concerned with the administration of a city or town or district rather than a larger area; "local taxes"; "local authorities"
public transport consisting of a bus or train that stops at all stations or stops; "the local seemed to take forever to get to New York"
affecting only a restricted part or area of the body; "local anesthesia"
of or belonging to or characteristic of a particular locality or neighborhood; "local customs"; "local schools"; "the local citizens"; "a local point of view"; "local outbreaks of flu"; "a local bus line"
any of several vasoconstrictor substances (trade name Hypertensin) that cause narrowing of blood vessels (同)angiotonin, Hypertensin
a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure

PrepTutorEJDIC

〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
『一地方の』,ある土地の,(特に)自分の住んでいる土地の;地方に特有な / (全体からみて)『部分的な』,局部の,狭い部分の / 《米》各駅停車の / 《話》《しばしば複数形で》その土地に住んでいる人々 / 《米話》(新聞の)地方記事 / 《話》(各駅停車の)列車,電車,バス / 《米》(労働組合などの)支部
低カロリーの

UpToDate Contents

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1. Overview of the renin-angiotensin system
2. 高血圧治療におけるレニン・アンギオテンシン系阻害 renin angiotensin system inhibition in the treatment of hypertension
3. 心臓におけるアンギオテンシンⅡの作用 actions of angiotensin ii on the heart
4. 心不全の病態生理：神経体液性の適応 pathophysiology of heart failure neurohumoral adaptations
5. 低レニン性原発性（本態性）高血圧 low renin primary essential hypertension

English Journal

Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421.

Lambert DW, Lambert LA1, Clarke NE1, Hooper NM1, Porter KE2, Turner AJ1.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Aug;127(4):243-9. doi: 10.1042/CS20130420.
ACE2 (angiotensin converting enzyme 2) plays a critical role in the local tissue RAS (renin-angiotensin system) by hydrolysing the potent hypertensive and mitogenic peptide AngII (angiotensin II). Changes in the levels of ACE2 have been observed in a number of pathologies, including cardiovascular d
PMID 24564768

Identification of bona fide alternative Renin transcripts expressed along cortical tubules and potential roles in promoting insulin resistance in vivo without significant plasma Renin activity elevation.

Ishigami T1, Kino T2, Chen L2, Minegishi S2, Araki N2, Umemura M2, Abe K2, Sasaki R2, Yamana H2, Umemura S2.
Hypertension.Hypertension.2014 Jul;64(1):125-33. doi: 10.1161/HYPERTENSIONAHA.114.03394. Epub 2014 Apr 28.
Renin belongs to a family of aspartyl proteases and is the rate-limiting enzyme in the synthesis of the potent vasoactive peptide angiotensin II. Processing of renal renin has been extensively investigated in juxtaglomerular granular cells, in which prorenin and active renin are present in secretory
PMID 24777979

Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease.

Eriguchi M1, Tsuruya K2, Haruyama N1, Yamada S1, Tanaka S1, Suehiro T1, Noguchi H1, Masutani K1, Torisu K1, Kitazono T1.
Kidney international.Kidney Int.2014 Jun 18. doi: 10.1038/ki.2014.220. [Epub ahead of print]
We elucidate the underlying mechanisms of bidirectional cardiorenal interaction, focusing on the sympathetic nerve driving disruption of the local renin-angiotensin system (RAS). A rat model of Nω-nitro-L-arginine methyl ester (L-NAME; a nitric oxide synthase inhibitor) administration was used to i
PMID 24940798

Japanese Journal

Involvement of Renin–Angiotensin System in Damage of Angiotensin-Converting Enzyme Inhibitor Captopril on Bone of Normal Mice

Liu Jin-Xin,Wang Liang,Zhang Yan
Biological and Pharmaceutical Bulletin 38(6), 869-875, 2015
… This study was performed to investigate the effect of angiotensin-converting enzyme inhibitor, captopril, on bone metabolism and histology, and the action of captopril on the components of the skeletal renin–angiotensin system (RAS) and bradykinin receptor in normal male mice. …
NAID 130005072666

腎臓レニン・アンジオテンシン系（RAS）：生命の環を支え，脅かすもの

香美祥二
日本小児腎臓病学会雑誌 26(2), 227-231, 2014
… レニン・アンジオテンシン系（RAS）は，腎臓レニンの発見以来，血圧や体液調節に必須の全身性調節機構（systemic RAS）という古典的コンセプトの時代を経て，RAS阻害に基づく降圧剤の開発とその臨床応用，新たな局所RAS（local RAS）コンセプトの時代へと目覚ましい展開を遂げている。 …
NAID 130004495413

Effects of Telmisartan on Inflammatory Cytokines and Coronary Plaque Component as Assessed on Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients

Yamaguchi Koji,Wakatsuki Tetsuzo,Soeki Takeshi,Niki Toshiyuki,Taketani Yoshio,Oeduka Hiroyasu,Kusunose Kenya,Ise Takayuki,Iwase Takashi,Yamada Hirotsugu,Sata Masataka
Circulation Journal 78(1), 240-247, 2014
… Background: Telmisartan has unique pleiotropic effects in addition to renin-angiotensin system (RAS)-inhibition effects. … The aim of this study was to evaluate the effects of telmisartan on the coronary plaque component and local inflammatory cytokines. … Conclusions: Decreased local inflammatory response and plaque stabilization on IB imaging were observed after 6 months of telmisartan treatment. …
NAID 130003382181