WordNet

any malignant tumor derived from epithelial tissue; one of the four major types of cancer
of or relating to or resembling a lobule

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/15 05:35:51」(JST)

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Lobular carcinoma is a form of tumor which primarily affects the lobules of a gland.

It is sometimes considered equivalent to "terminal duct carcinoma".^[1]

If not otherwise specified, it generally refers to breast cancer. Examples include:

Lobular carcinoma in situ
Invasive lobular carcinoma

References

^ "lobular carcinoma" at Dorland's Medical Dictionary

This article about a neoplasm is a stub. You can help Wikipedia by expanding it.

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1. 乳癌の病理 pathology of breast cancer
2. 異型および上皮内小葉癌：乳癌のハイリスク病変 atypia and lobular carcinoma in situ high risk lesions of the breast
3. 非浸潤性乳管癌：疫学、臨床症状、および診断 breast ductal carcinoma in situ epidemiology clinical manifestations and diagnosis
4. 新たに診断された非転移性乳癌の治療の概要 overview of the treatment of newly diagnosed non metastatic breast cancer
5. 乳癌の臨床的特徴、診断および病期分類 clinical features diagnosis and staging of newly diagnosed breast cancer

English Journal

Indication for relumpectomy-a useful scoring system in cases of invasive breast cancer.

Halevy A, Lavy R, Pappo I, Davidson T, Gold-Deutch R, Jeroukhimov I, Shapira Z, Wassermann I, Sandbank J, Chikman B.SourceDivision of Surgery, Assaf Harofeh Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel), Zerifin, Israel; Comprehensive Breast Care Institute, Assaf Harofeh Medical Center (affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel), Zerifin, Israel. ahalevi@asaf.health.gov.il.
Journal of surgical oncology.J Surg Oncol.2012 Mar 15;105(4):376-80. doi: 10.1002/jso.22027. Epub 2011 Jul 20.
BACKGROUND AND OBJECTIVES: In two-thirds of breast cancer patients undergoing reoperation no residual tumor will be found. A scoring system for selection of patients who might benefit from relumpectomy is proposed.METHODS: This study is based on 293 patients with invasive breast cancer undergoing re
PMID 21780127

Organotropism and prognostic marker discordance in distant metastases of breast carcinoma: fact or fiction? A clinicopathologic analysis.

St Romain P, Madan R, Tawfik OW, Damjanov I, Fan F.AbstractPrior studies have suggested that the type of breast cancer influences the location of distant metastases ("organotropism") and that there may be discordance of estrogen receptor and human epidermal growth factor receptor 2 (Her2) expression between primaries and metastases. Our aims were to investigate the relationship between tumor type and metastatic site and to compare biomarker expression between primary and metastatic tumors. We retrospectively reviewed 102 biopsy-proven cases of breast cancer metastatic to distant sites from 2000 to 2010 and 34 corresponding primaries for histologic subtype, grade, lymphovascular invasion, lymph node metastasis, and expression of estrogen receptor and Her2. Most metastases were of ductal (88) and lobular (11) histologic types. Available data on primaries indicated that the majority were grade III with positive lymph node metastasis and lymphovascular invasion. Biomarkers on 73 metastases showed 37 estrogen receptor positive/Her2-, 6 estrogen receptor positive/Her2+, 8 estrogen receptor negative/Her2+, and 22 estrogen receptor negative/Her2-. The most common metastatic sites were the lung (26%), bone (32%), and liver (21%). We found no association between estrogen receptor/Her2 profile and metastatic site (P = .16). When compared with ductal carcinoma, lobular carcinoma showed a unique metastatic pattern to gastrointestinal tract/gynecologic sites (P = .014). Of 34 cases with paired prognostic markers for primary and metastatic sites, 7 (20%) demonstrated discordance in estrogen receptor-positive/Her2 profile between the primary and the metastasis. Because the estrogen receptor-positive/Her2 profile of metastatic breast cancer did not always match that of the primary tumor, it is important to repeat the prognostic markers of metastasis.
Human pathology.Hum Pathol.2012 Mar;43(3):398-404. Epub 2011 Aug 12.
Prior studies have suggested that the type of breast cancer influences the location of distant metastases ("organotropism") and that there may be discordance of estrogen receptor and human epidermal growth factor receptor 2 (Her2) expression between primaries and metastases. Our aims were to investi
PMID 21840040

Japanese Journal

症例報告腋窩リンパ節転移で発見され胸筋温存乳房切除術を施行した潜在性乳癌の2例

深光岳,野島真治,杉山望 [他],金田好和,須藤隆一郎,亀井敏昭
山口医学 = Yamaguchi medical journal 64(2), 153-157, 2015-05
… Axillary lymph node biopsy revealed invasive lobular breast carcinoma. … Axillary lymph node biopsy revealed invasive ductal breast carcinoma, leading to a diagnosis of latent breast cancer. …
NAID 120005617817

広範な他臓器転移を認めた乳腺浸潤性小葉癌の1剖検例

野口英一郎,神尾孝子,江崎治朗 [他],中島マリア美知子,神尾英則,塚田弘子,大地哲也,澤田達男,亀岡信悟
東京女子医科大学雑誌 85(E1), E19-E26, 2015-03-31
症例は79歳女性。左乳房の局所進行浸潤性小葉癌で手術を施行。術後補助療法として5年間のアロマターゼ阻害剤を内服し、術後5年目の定期検診では明らかな再発所見を認めていなかったが、術後6年4ヶ月に広範な消化管転移と胸膜・腹膜播種を認めた。再発治療後19ヶ月で、膀胱転移による膀胱粘膜よりの出血コントロールがつかず亡くなったが、剖検により直接死因は膀胱内血腫形成に伴う腎後性腎不全と推定された。再発治療後の …
NAID 110009888976