ketamine

出典: meddic

ケタミン

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「a general anesthetic and tranquilizer (not a barbiturate) that is administered intravenously or intramuscularly; used mainly by veterinarians or for minor surgery with geriatric or pediatric patients; taken in large doses it causes hallucinations similar to those associated with the use of PCP」
ketamine hydrochloride, Ketalar

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/29 11:13:31」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/15 11:49:11」(JST)

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英文文献

  • Sex-specific alterations in behavioral and cognitive functions in a "three hit" animal model of schizophrenia.
  • Kekesi G1, Petrovszki Z2, Benedek G3, Horvath G4.
  • Behavioural brain research.Behav Brain Res.2015 May 1;284:85-93. doi: 10.1016/j.bbr.2015.02.015. Epub 2015 Feb 16.
  • Whereas schizophrenia affects both human sexes, there are known sex-dependent disparities. We developed a chronic animal model that shows some schizophrenia-related deficits in rats by applying selective breeding after subchronic ketamine administration connected with postweaning social isolation (c
  • PMID 25698594
  • Drug development in schizophrenia: are glutamatergic targets still worth aiming at?
  • Goff DC1.
  • Current opinion in psychiatry.Curr Opin Psychiatry.2015 May;28(3):207-15. doi: 10.1097/YCO.0000000000000152.
  • PURPOSE OF REVIEW: The ketamine model has dominated drug discovery in schizophrenia over the past decade, supported by genetic and postmortem evidence implicating glutamatergic transmission. This review assesses recent successes and disappointments of glutamatergic agents and identifies promising ne
  • PMID 25710242
  • The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia.
  • Hadi SM1, Saleh AJ1, Tang YZ1, Daoud A2, Mei X1, Ouyang W3.
  • International journal of pediatric otorhinolaryngology.Int J Pediatr Otorhinolaryngol.2015 May;79(5):671-6. doi: 10.1016/j.ijporl.2015.02.012. Epub 2015 Feb 19.
  • BACKGROUND: Postoperative emergency agitation (EA) is a common problem often observed in children undergoing general anesthesia. The purpose of this study was to evaluate whether a bolus of intraoperative low-dose ketamine followed by dexmedetomidine i.v. could reduce the incidence of EA in children
  • PMID 25770644
  • Comparison of hollow fiber liquid-phase microextraction and ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction for the determination of drugs of abuse in biological samples by gas chromatography-mass spectrometry.
  • Meng L1, Zhang W2, Meng P3, Zhu B4, Zheng K4.
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2015 May 1;989:46-53. doi: 10.1016/j.jchromb.2015.02.039. Epub 2015 Mar 9.
  • Two microextraction techniques based on hollow fiber liquid-phase microextraction (HF-LPME) and ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction (UA-LDS-DLLME) had been applied for the determination of drugs of abuse (methamphetamine, amphetamine, 3,4-methylenedioxyme
  • PMID 25801996

和文文献

関連リンク

Ketamine is a drug used in human and veterinary medicine. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar. Pharmacologically, ketamine is classified as an NMDA receptor antagonist. At high, fully anesthetic level doses, ...
ケタミン(Ketamine)はフェンサイクリジン系麻酔薬のひとつで、第一三共株式会社から 塩酸塩としてケタラール®の名で販売されている医薬品。解離性麻酔薬(大脳皮質など を抑制し、大脳辺縁系に選択的作用を示す)のひとつ。静注用・筋注用として提供されて ...

関連画像

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★リンクテーブル★
リンク元ケタミン
拡張検索ketamine hydrochloride

ケタミン」

  [★]

ketamine
塩酸ケタミン ketamine hydrochloride
ケタラール Ketalar


分類

  • 解離性静脈麻酔薬

概念

  • 中枢神経に作用して、意識消失、鎮痛作用をもたらす
  • 大脳皮質や視床を抑制する(体性知覚抑制)
  • 大脳辺縁系・網様体賦活系は活性化(向精神作用)
  • そのため、覚醒時に不快な夢や幻覚を伴う
  • 呼吸抑制が弱い(小児検査麻酔にも筋肉内注射で使用される)
  • 血圧を上昇させることから、ハイリスク患者の麻酔導入や喘息患者の麻酔導入で使用される
  • カタレプシ様。目は半開き。→独特の顔貌を呈する
  • ○:注射できる(筋肉注射)。呼吸抑制がない。強力な鎮痛作用
  • ×:精神症状出現。唾液分泌亢進。血圧↑。心拍↑。肺動脈圧↑。脳内圧↑。

薬理作用

  • 催眠作用、鎮痛作用

注意

  • 頭蓋内圧が上昇するため、脳外科の手術には推奨されない

相互作用

添付文書

  • ケタラール静注用50mg/ケタラール静注用200mg
[display]http://www.info.pmda.go.jp/go/pack/1119400A1031_3_07/1119400A1031_3_07?view=body


ketamine hydrochloride」

  [★]

ketamine




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