関: isocitrate

WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/15 07:53:22」(JST)

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Isocitric acid is a structural isomer of citric acid. Salts and esters of isocitric acid are known as isocitrates. The isocitrate anion is a substrate of the citric acid cycle. Isocitrate is formed from citrate with the help of the enzyme aconitase, and is acted upon by isocitrate dehydrogenase.

Isocitric acid is commonly used as a marker to detect the authenticity and quality of fruit products, most often citrus juices. In authentic orange juice, for example, the ratio of citric acid to D-isocitric acid is usually less than 130. An isocitric acid value higher than this may be indicative of fruit juice adulteration.^[1]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=TCA Cycle edit]]

File:TCACycle WP78.png

TCA Cycle edit

^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".

References

^ Saavedra, L.; Garcia, A.; Barbas, C. (9 June 2000). "Development and validation of a capillary electrophoresis method for direct measurement of isocitric, citric, tartaric and malic acids as adulteration markers in orange juice". Journal of Chromatography A. 881 (1-2): 395–401. PMID 10905722.

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English Journal

The effect of oxalic and itaconic acids on threo-Ds-isocitric acid production from rapeseed oil by Yarrowia lipolytica.

Kamzolova SV1, Allayarov RK2, Lunina JN2, Morgunov IG2.
Bioresource technology.Bioresour Technol.2016 Apr;206:128-33. doi: 10.1016/j.biortech.2016.01.092. Epub 2016 Feb 1.
The effect of oxalic and itaconic acids, the inhibitors of the isocitrate lyase, on the production of isocitric acid by the wild strain Yarrowia lipolytica VKM Y-2373 grown in the medium containing rapeseed oil was studied. In the presence of oxalic and itaconic acids, strain Y. lipolytica accumulat
PMID 26851896

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.

Yoshimi N1,2, Futamura T2, Bergen SE3, Iwayama Y4, Ishima T1, Sellgren C5, Ekman CJ6, Jakobsson J7, Pålsson E7, Kakumoto K8, Ohgi Y2, Yoshikawa T4, Landén M3,7, Hashimoto K1.
Molecular psychiatry.Mol Psychiatry.2016 Jan 19. doi: 10.1038/mp.2015.217. [Epub ahead of print]
Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, the precise biological basis remains unknown, hampering the search for novel biomarkers. In this study, we performed metabolomics of cerebrospinal fluid (CSF) from male BD patients (n=54)
PMID 26782057

Implication of Metabolomic profiles to wide thermoneutral zone in Mongolian gerbils (Meriones unguiculatus).

Shi Y1,2, Wang D1.
Integrative zoology.Integr Zool.2016 Jan 9. doi: 10.1111/1749-4877.12179. [Epub ahead of print]
Mongolian gerbils (Meriones unguiculatus) have evolved a wide thermoneutral zone (26.5-38.9 ºC) and high upper critical temperature, and appear to have a high tolerance for heat exposure. Here, we use a metabolomic approach to measure global metabolite profiles for gerbils between lower (27 ºC) an
PMID 26749160

Japanese Journal

新規な配位子交換―キャピラリー電気泳動法による有機酸及び単糖の光学異性体分析

小玉修嗣,赤羽麻美,會澤宣一,多賀淳,山本敦,早川和一
分析化学 63(5), 371-382, 2014
キャピラリー電気泳動法は分離効率が高く，多種多様な光学分割剤を任意の濃度で利用できるため，光学異性体分析には有効な方法である．この方法が初めて光学異性体分析に適用されたのは，アミノ酸を配位子に，Cu(II)イオンを中心イオンに用いた配位子交換法によりアミノ酸を光学異性体分離した研究である．その後，配位子交換法はアミノ酸の光学異性体分析法の一つと位置付けられてきた．著者らは，従来の配位子交換法を拡張 …
NAID 130004428005

ハナビラタケ子実体の貯蔵中における炭水化物および有機酸の変化

吉田博,内田美和子,小野優子
日本きのこ学会誌 : mushroom science and biotechnology 14(2), 81-90, 2006-07-25
ハナビラタケ子実体中の5貯蔵温度(30,20,10,5,0℃)における無包装貯蔵および密封包装貯蔵(厚さ100μmのポリエチレンフィルム袋)の低分子炭水化物,酢酸可溶多糖(グリコーゲン様多糖),有機酸含量の変化について検討した.(1)ハナビラタケの無包装貯蔵の鮮度保持期間は,30℃で4日,20℃で7日,10℃で14日,5℃で18日,0℃で19日であった.厚さ100μmのポリエチレンフィルム袋を用い …
NAID 110008675280

ハナビラタケ菌糸体の栄養生長にともなう炭水化物および有機酸の変遷

吉田博
日本きのこ学会誌 : mushroom science and biotechnology 13(3), 149-155, 2005-10-25
ハナビラタケの栄養生長にともなう菌糸体中の低分子炭水化物,グリコーゲンおよび有機酸の分布変化を検討した.培地中にギ酸,酢酸,シュウ酸,コハク酸,フマル酸,リンゴ酸,クエン酸およびイソクエン酸が集積し,シュウ酸の集積は他の有機酸類よりも顕著であった.乾燥重量あたり,栄養生長中の菌糸体の低分子炭水化物含量は9.5〜15.5%の範囲であった.菌糸体からトレハロース,グルコース,フルクトース,アラビトール …
NAID 110008675270

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★リンクテーブル★

リンク元	「isocitrate」

「isocitrate」

Isocitric acid
Names
	IUPAC name 1-Hydroxypropane-1,2,3-tricarboxylic acid
Identifiers
CAS Number	320-77-4 ;
3D model (Jmol)	Interactive image;
ChEBI	CHEBI:30887 ;
ChemSpider	1161 ;
DrugBank	DB01727 °;
ECHA InfoCard	100.005.713
KEGG	C00311 ;
MeSH	Isocitrate
PubChem CID	1198;
	InChI InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13) Key: ODBLHEXUDAPZAU-UHFFFAOYSA-N ; InChI=1/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13) Key: ODBLHEXUDAPZAU-UHFFFAOYAX ;
	SMILES O=C(O)C(CC(=O)O)C(O)C(=O)O ;
Properties
Chemical formula	C6H8O7
Molar mass	192.124
Melting point	105 °C (221 °F; 378 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

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イソクエン酸

関: isocitric acid

[WikiPathways-2] The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".

[Saavedra-1] Saavedra, L.; Garcia, A.; Barbas, C. (9 June 2000). "Development and validation of a capillary electrophoresis method for direct measurement of isocitric, citric, tartaric and malic acids as adulteration markers in orange juice". Journal of Chromatography A. 881 (1-2): 395–401. PMID 10905722.

v t e Citric acid cycle metabolic pathway
			Oxaloacetate			Malate			Fumarate			Succinate			Succinyl-CoA


Acetyl-CoA				NADH + H⁺	NAD⁺			H₂O		FADH₂	FAD		CoA + ATP(GTP)	P_i + ADP(GDP)
	+	H₂O														NADH + H⁺ + CO₂
		CoA														NAD⁺
					H₂O		H₂O			NAD(P)⁺	NAD(P)H + H⁺			CO₂


			Citrate			cis-Aconitate			Isocitrate			Oxalosuccinate			α-Ketoglutarate

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案内

isocitric acid