intracellular fluid

出典: meddic

細胞内液 ICF

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/08 01:15:03」(JST)

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英文文献

  • A8.9 Rheumatoid arthritis synovial IL-21 + CD4+ t cells specifically induce matrix metalloproteinase production by fibroblast-like synoviocytes.
  • Cristina Lebre M1, Vieira PL, Aarrass S, Newsom-Davis T, Tak PP, Screaton GR.Author information 1Amsterdam Rheumatology & Immunology Center.AbstractBACKGROUND/PURPOSE: IL-21 is a cytokine produced by activated CD4+ T cells and T follicular helper cells (TFh) that has been implicated in several autoimmune diseases including rheumatoid arthritis (RA). IL-21 regulates antibody production by B cells and induces osteoclastogenesis, mechanisms that contribute to rheumatoid arthritis (RA) pathology. Importantly, IL-21R blockade ameliorates arthritis in mice. Here we investigated the functional characteristics of synovial CD4+ IL-21 + T cells in RA.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2014 Mar 1;73 Suppl 1:A79. doi: 10.1136/annrheumdis-2013-205124.183.
  • BACKGROUND/PURPOSE: IL-21 is a cytokine produced by activated CD4+ T cells and T follicular helper cells (TFh) that has been implicated in several autoimmune diseases including rheumatoid arthritis (RA). IL-21 regulates antibody production by B cells and induces osteoclastogenesis, mechanisms that c
  • PMID 24489312
  • Physicochemical properties and in vitro intestinal permeability properties and intestinal cell toxicity of silica particles, performed in simulated gastrointestinal fluids.
  • Sakai-Kato K1, Hidaka M2, Un K2, Kawanishi T3, Okuda H3.Author information 1Division of Drugs, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. Electronic address: kumikato@nihs.go.jp.2Division of Drugs, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.3National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.AbstractBACKGROUND: Amorphous silica particles with the primary dimensions of a few tens of nm, have been widely applied as additives in various fields including medicine and food. Especially, they have been widely applied in powders for making tablets and to coat tablets. However, their behavior and biological effects in the gastrointestinal tracts associated with oral administration remains unknown.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1840(3):1171-80. doi: 10.1016/j.bbagen.2013.12.014. Epub 2013 Dec 19.
  • BACKGROUND: Amorphous silica particles with the primary dimensions of a few tens of nm, have been widely applied as additives in various fields including medicine and food. Especially, they have been widely applied in powders for making tablets and to coat tablets. However, their behavior and biolog
  • PMID 24361607
  • Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: Interplay between nanostructure and composition.
  • Pozzi D1, Marchini C2, Cardarelli F3, Salomone F4, Coppola S5, Montani M2, Zabaleta ME2, Digman MA6, Gratton E6, Colapicchioni V1, Caracciolo G7.Author information 1Department of Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy.2Department of Bioscience and Biotechnology, University of Camerino, Via Gentile III da Varano, 62032 Camerino, MC, Italy.3Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy.4Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy; NEST, Scuola Normale Superiore and Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127 Pisa, Italy.5Department of Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy; Department of Anatomy, Histology, Forensic Medicine and Orthopedics, "Sapienza" University of Rome, Via A. Borelli, 50, 00161 Rome, Italy.6Laboratory for Fluorescence Dynamics, Department of Biomedical Engineering, University of California, Irvine, 3120 Natural Sciences 2, Irvine, CA 92697-2715, USA.7Department of Molecular Medicine, "Sapienza" University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy. Electronic address: giulio.caracciolo@uniroma1.it.AbstractHere we present a quantitative mechanism-based investigation aimed at comparing the cell uptake, intracellular trafficking, endosomal escape and final fate of lipoplexes and lipid-protamine/deoxyribonucleic acid (DNA) (LPD) nanoparticles (NPs) in living Chinese hamster ovary (CHO) cells. As a model, two lipid formulations were used for comparison. The first formulation is made of the cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and the zwitterionic lipid dioleoylphosphocholine (DOPC), while the second mixture is made of the cationic 3β-[N-(N,N-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and the zwitterionic helper lipid dioleoylphosphatidylethanolamine (DOPE). Our findings indicate that lipoplexes are efficiently taken up through fluid-phase macropinocytosis, while a less efficient uptake of LPD NPs occurs through a combination of both macropinocytosis and clathrin-dependent pathways. Inside the cell, both lipoplexes and LPD NPs are actively transported towards the cell nucleus, as quantitatively addressed by spatio-temporal image correlation spectroscopy (STICS). For each lipid formulation, LPD NPs escape from endosomes more efficiently than lipoplexes. When cells were treated with DOTAP-DOPC-containing systems the majority of the DNA was trapped in the lysosome compartment, suggesting that extensive lysosomal degradation was the rate-limiting factors in DOTAP-DOPC-mediated transfection. On the other side, escape from endosomes is large for DC-Chol-DOPE-containing systems most likely due to DOPE and cholesterol-like molecules, which are able to destabilize the endosomal membrane. The lipid-dependent and structure-dependent enhancement of transfection activity suggests that DNA is delivered to the nucleus synergistically: the process requires both the membrane-fusogenic activity of the nanocarrier envelope and the employment of lipid species with intrinsic endosomal rupture ability.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Mar;1838(3):957-67. doi: 10.1016/j.bbamem.2013.11.014. Epub 2013 Dec 1.
  • Here we present a quantitative mechanism-based investigation aimed at comparing the cell uptake, intracellular trafficking, endosomal escape and final fate of lipoplexes and lipid-protamine/deoxyribonucleic acid (DNA) (LPD) nanoparticles (NPs) in living Chinese hamster ovary (CHO) cells. As a model,
  • PMID 24296066

和文文献

  • Combined effects of flow-induced shear stress and micropatterned surface morphology on neuronal differentiation of human mesenchymal stem cells(CELL AND TISSUE ENGINEERING)
  • Jeon Kang Jin,Park So Hee,Shin Ji Won,Kang Yun Gyeong,Hyun Jin-Sook,Oh Min Jae,Kim Seon Yeon,Shin Jung-Woog
  • Journal of bioscience and bioengineering 117(2), 242-247, 2014-02
  • … Functional evaluations were also performed by monitoring the intracellular calcium concentration and the expression of synaptophysin, β-tubulin III, and MAP2. …
  • NAID 110009804080
  • Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses
  • Koga Hikari,Miyahara Nobuaki,Fuchimoto Yasuko,Ikeda Genyo,Waseda Koichi,Ono Katsuichiro,Tanimoto Yasushi,Kataoka Mikio,Gelfand Erwin W.,Tanimoto Mitsune,Kanehiro Arihiko
  • Respiratory Research 14, 2013-01-24
  • … PAR-2 expression in the lung tissues was enhanced following secondary challenge, and that PAR-2 intracellular expression on peribronchial lymph node (PBLN) T cells was also increased following allergen challenge of sensitized mice. … Levels of IL-4, IL-5 and IL-13, and eotaxin in BAL fluid 6 hr after secondary allergen challenge were significantly suppressed by the treatment. …
  • NAID 120005324791
  • Angiotensin II Induces Modulation of Calcium Channel Currents in Osteoblasts
  • Tazaki Masakazu,Endoh Takayuki,Kobayashi Hiroshi,Ohkubo Mai,Sueishi Kenji
  • The Bulletin of Tokyo Dental College 54(4), 275-278, 2013
  • … Angiotensin II (Ang II) plays a major role in the maintenance of extracellular fluid volume and blood pressure. … Osteoblasts play a major role in bone formation, employing intracellular Ca2+ as a second messenger to modulate hormonal responses and as a cofactor for mineralization. …
  • NAID 130004471740

関連リンク

...among the cells and the extracellular fluids of the body. The human body is basically a collection of cells grouped together into organ systems and bathed in fluids, most notably the blood. The intracellular fluid is the fluid contained ...
In this lesson you will find the definition of intracellular fluid. In addition, the composition of intracellular fluid and how water moves in and... ... What is Intracellular Fluid? Human cells are bathed in fluids both inside the cell and out. In ...

関連画像

Body Fluids and Fluid Compartments - VOERTranscellular FluidIntracellular Fluid Related Keywords Intracellular Fluid Related Keywords Various Body Fluid Compartments submited Extracellular Fluid (Interstitial Fluid)


★リンクテーブル★
リンク元細胞内液」「ICF」「intracellular solution」「ICE
関連記事fluid」「intracellular」「flu

細胞内液」

  [★]

intracellular fluid ICF
細胞外液

体液量

  新生児 乳児 幼児 成人 高齢者
全体液量 80 70 65 60 50
 細胞内液40 40 40 40 35
 細胞外液40 30 25 20 15
  組織間液 35 25 20 15 10
  血漿 5 5 5 5 5

性差、年齢

  • 女性、肥満者は脂肪細胞(水分を保持しない)のために体液量が男性より少ない
  • 新生児には組織間液が多い

細胞内液の組成

  • 細胞内液の陰イオンはリン酸イオンが大半を占め、次いで蛋白質、であり重炭酸イオンや塩素イオンはわずかである。(SP.761)。リン酸イオンが多いのは細胞内のATPの合成に使われる他、pH緩衝にも用いられるため、と思う。



ICF」

  [★]


intracellular solution」

  [★]

intracellular fluid


ICE」

  [★]

intracellular fluid


fluid」

  [★]

BALF

WordNet   license wordnet

「subject to change; variable; "a fluid situation fraught with uncertainty"; "everything was unstable following the coup"」
unstable

WordNet   license wordnet

「a substance that is fluid at room temperature and pressure」

WordNet   license wordnet

「continuous amorphous matter that tends to flow and to conform to the outline of its container: a liquid or a gas」

PrepTutorEJDIC   license prepejdic

「『流体』,流動体 / 『流動性の』,流動する / 流体の,流動体から成る / 変わりやすい,固定していない,浮動する」

WordNet   license wordnet

「in cash or easily convertible to cash; "liquid (or fluid) assets"」
liquid

WordNet   license wordnet

「affording change (especially in social status); "Britain is not a truly fluid society"; "upwardly mobile"」
mobile

WordNet   license wordnet

「characteristic of a fluid; capable of flowing and easily changing shape」
runny

intracellular」

  [★]

  • adj.
  • 細胞内の、細胞内での
adv. intracellularly

WordNet   license wordnet

「located or occurring within a cell or cells; "intracellular fluid"」


flu」

  [★]

grippeinfluenza

PrepTutorEJDIC   license prepejdic

「インフルエンザ,流感」




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