WordNet

any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

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Preventive Effects of Egyptian Sweet Marjoram (Origanum majorana L.) Leaves on Haematological Changes and Cardiotoxicity in Isoproterenol-Treated Albino Rats.

Ramadan G, El-Beih NM, Arafa NM, Zahra MM.SourceZoology Department, Faculty of Science, Ain Shams University, Abbasseya, Cairo, 11566, Egypt, gamal_ramadan@hotmail.com.
Cardiovascular toxicology.Cardiovasc Toxicol.2013 Jun;13(2):100-9. doi: 10.1007/s12012-012-9189-4.
We made an attempt to evaluate/compare the cardioprotective activity of two different doses (50 and 100 mg/kg body weight, given orally for 30 consecutive days) of Egyptian sweet marjoram leaf powder (MLP) and marjoram leaf aqueous extract (MLE) against isoproterenol (ISO)-induced myocardial infarc
PMID 23054890

Enhancing antibacterial activity of surface-grafted chitosan with immobilized lysozyme on bioinspired stainless steel substrates.

Yuan S, Yin J, Jiang W, Liang B, Pehkonen SO, Choong C.SourceMulti-phases Mass Transfer & Reaction Engineering Lab, College of Chemical Engineering, Sichuan University, Chengdu 610065, China. yuanshaojun@gmail.com
Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Jun 1;106:11-21. doi: 10.1016/j.colsurfb.2012.12.048. Epub 2013 Jan 20.
Bacterial infections have been widely recognized as a major cause of the failure of medical implants and devices. One promising strategy to reduce the incidence of infections is to impart the material surfaces with bactericidal function for inhibiting bacterial adhesion and biofilm formation. In thi
PMID 23434686

Antityrosinase and antimicrobial activities of furfuryl alcohol, furfural and furoic acid.

Chai WM, Liu X, Hu YH, Feng HL, Jia YL, Guo YJ, Zhou HT, Chen QX.SourceSchool of Life Sciences, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, Xiamen University, Xiamen 361005, China.
International journal of biological macromolecules.Int J Biol Macromol.2013 Jun;57:151-5. doi: 10.1016/j.ijbiomac.2013.02.019. Epub 2013 Mar 4.
The inhibitory kinetics of furfuryl alcohol, furfural and furoic acid on mushroom tyrosinase have been investigated. The results showed that these furan compounds were reversible inhibitors of the enzyme. Furthermore, furfuryl alcohol and furfural were found to be mixed-type inhibitors while furoic
PMID 23466497

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Kizuka Yasuhiko,Kitazume Shinobu,Fujinawa Reiko,Saito Takashi,Iwata Nobuhisa,Saido Takaomi C.,Nakano Miyako,Yamaguchi Yoshiki,Hashimoto Yasuhiro,Staufenbiel Matthias,Hatsuta Hiroyuki,Murayama Shigeo,Manya Hiroshi,Endo Tamao,Taniguchi Naoyuki
EMBO Molecular Medicine 7(2), 175-189, 2015-02-01
… The β-site amyloid precursor protein cleaving enzyme-1 (BACE1), an essential protease for the generation of amyloid-β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). … However, there is a concern that inhibiting BACE1 could also affect several physiological functions. …
NAID 120005549837

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Journal of Applied Glycoscience advpub(0), 2015
… In GH13 SBSs have been seen in 17 subfamilies including SBSs with highly diverse functions in the same enzyme. … Compared to wild-type, W23A/Y44A AnAbf62A-m2,3 retained 45% activity on WAX and was less retarded in AGE by WAX as well as by barley β-glucan and birchwood xylan, which are neither hydrolysed nor inhibiting activity towards WAX. …
NAID 130005060850

Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin

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Biological and Pharmaceutical Bulletin 38(2), 292-297, 2015
… Both CYP enzymes and carboxylesterase 1 (CES1) are involved in the metabolism of clopidogrel, while CES1 is believed to be the enzyme responsible for the activation of simvastatin. … Some in vitro studies have suggested that simvastatin could attenuate clopidogrel activation via inhibiting CYP3A activity. … Moreover, we provided evidence that CES1 is not an efficient enzyme for catalyzing simvastatin activation. …
NAID 130004872259