infliximab

出典: meddic

インフリキシマブ


WordNet   license wordnet

「a monoclonal antibody (trade name Remicade) used to treat Crohn''s disease and rheumatoid arthritis; administered by infusion; use and dosage must be determined by a physician」
Remicade

WordNet   license wordnet

「an anti-TNF compound (trade name Remicade) consisting of an antibody directed against TNF; it is given intravenously at one-month to three-month intervals; used in treatment of regional enteritis and rheumatoid arthritis」
Remicade

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/03 09:46:57」(JST)

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英文文献

  • Infliximab in ulcerative colitis: real-life analysis of factors predicting treatment discontinuation due to lack of response or colectomy: ECIA (ACAD Colitis and Infliximab Study).
  • Fernández-Salazar L1, Muñoz F2, Barrio J3, Muñoz C4, Pajares R5, Rivero M6, Prieto V7, Legido J8, Bouhmidi A9, Herranz M10, Fernández N2, Sánchez-Ocaña R3, Joao D2, Santos F3.
  • Scandinavian journal of gastroenterology.Scand J Gastroenterol.2016 Feb;51(2):186-95. doi: 10.3109/00365521.2015.1070900. Epub 2015 Jul 22.
  • OBJECTIVE: To describe clinical practice with infliximab (IFX) in ulcerative colitis (UC); identification of predictive factors for IFX treatment discontinuation due to insufficient response and for colectomy.MATERIAL AND METHODS: Retrospective, multicentric and observational study including every U
  • PMID 26200929
  • Biologic Therapies: Anti-Tumor Necrosis Factor-α, Anti-Interleukins, Rituximab and Others.
  • Bhatt N, Tucker W, Sen HN, Nussenblatt RB.
  • Developments in ophthalmology.Dev Ophthalmol.2016;55:252-64. doi: 10.1159/000431201. Epub 2015 Oct 26.
  • Biologic agents are a group of therapeutic agents targeting mediators of inflammation, including soluble factors (e.g. cytokines and chemokines), cytokine/chemokine receptors and immune cell surface markers. The purpose of this chapter is to introduce the use of biologic therapies for the treatment
  • PMID 26501216
  • The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course.
  • Guinet-Charpentier C1, Champigneulle J2, Williet N3, Peyrin-Biroulet L3, Morali A1.
  • Scandinavian journal of gastroenterology.Scand J Gastroenterol.2016 Jan;51(1):33-40. doi: 10.3109/00365521.2015.1058415. Epub 2015 Jul 8.
  • OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory condition. Previous reports suggested that UC may have a worse prognosis when associated with auto-immune diseases. We compared characteristics at diagnosis and natural history of the disease between classical ulcerative colitis (CUC) and
  • PMID 26152794
  • Association between tobacco smoking and response to tumour necrosis factor α inhibitor treatment in psoriatic arthritis: results from the DANBIO registry.
  • Højgaard P1, Glintborg B2, Hetland ML3, Hansen TH4, Lage-Hansen PR5, Petersen MH6, Holland-Fischer M7, Nilsson C8, Loft AG9, Andersen BN10, Adelsten T11, Jensen J12, Omerovic E13, Christensen R14, Tarp U15, Østgård R16, Dreyer L17.
  • Annals of the rheumatic diseases.Ann Rheum Dis.2015 Dec;74(12):2130-6. doi: 10.1136/annrheumdis-2014-205389. Epub 2014 Jul 25.
  • OBJECTIVES: To investigate the association between tobacco smoking and disease activity, treatment adherence and treatment responses among patients with psoriatic arthritis (PsA) initiating the first tumour necrosis factor α inhibitor therapy (TNFi) in routine care.METHODS: Observational cohort stu
  • PMID 25063827

和文文献

  • TNF阻害薬 (特集 膠原病・リウマチ性疾患の治療の現状と展望) -- (生物学的製剤)
  • 天野 宏一
  • 日本内科学会雑誌 100(10), 2966-2971, 2011-10-10
  • NAID 40019038636
  • 症例 インフリキシマブとエトレチナートの併用にてコントロールしえた汎発性膿疱性乾癬の1例
  • 山本 瑞穂,多田 弥生,管 析 [他]
  • 皮膚科の臨床 53(10), 1415-1419, 2011-10
  • NAID 40019022249
  • クローン病に対するインフリキシマブ療法の内視鏡的モニタリング
  • Bjorkesten Clas-Goran af,Nieminen Urpo,Turunen Ulla [他]
  • Inflammatory bowel diseases 2(3), 12-19, 2011-09
  • NAID 40019036670

関連リンク

Infliximab has adverse effects, some life-threatening, common to drugs in the class of immunosuppressants (which also includes etanercept (Enbrel) and adalimumab (Humira)). Some of the most severe are: serious and sometimes ...
イド依存性潰瘍性大腸炎患者に対し,寛解導入ならびに寛解維持目的で Infliximab 投与を施行した. 第 5 回目の Infliximab 投与後に多関節痛,リンパ球減少,抗二本鎖 DNA 抗体陽性,抗核抗体陽性を. 呈し薬剤誘発性ループスと診断した ...
Infliximab is a prescription medication used to treat conditions in which the immune system attacks the body causing... ... Infliximab is a prescription medication used for patients with: Rheumatoid Arthritis - adults with moderately to ...

関連画像

KCRA | INFLIXIMABInfliximabInfliximab recibe la autorización europea Infliximab. Causes, symptoms, treatment REMICADE® (Infliximab), Powder, 100mg Infliximab (Remicade): effetti collaterali Infliximab: Efficacy in psoriasis Arsiwala infliximab - sandalyan


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infliximab
レミケード


  • TNF受容体に結合したTNFαに結合するモノクローナル抗体
  • マウスとヒトのキメラ抗体

特徴

構造

作用機序

薬理作用

抗菌スペクトル

動態

効能又は効果

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  • 既存治療で効果不十分な下記疾患
  • 関節リウマチ(関節の構造的損傷の防止を含む)
  • ベーチェット病による難治性網膜ぶどう膜炎
  • 尋常性乾癬、関節症性乾癬、膿疱性乾癬、乾癬性紅皮症
  • 強直性脊椎炎
  • 次のいずれかの状態を示すクローン病の治療及び維持療法(既存治療で効果不十分な場合に限る)
  • 中等度から重度の活動期にある患者
  • 外瘻を有する患者
  • 中等症から重症の潰瘍性大腸炎の治療(既存治療で効果不十分な場合に限る)

注意

禁忌

副作用

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