WordNet

a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
the action of incorporating a racial or religious group into a community (同)integrating, desegregation
an operation used in the calculus whereby the integral of a function is determined

PrepTutorEJDIC

ビールス,ろ過性病原体
統合,集成,完成 / (学校や住居における)人種差別の撤廃

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1. Virus-induced wheezing and asthma: An overview
2. 小児におけるB型肝炎ウイルス感染の概要 overview of hepatitis b virus infection in children
3. 小児におけるA型肝炎ウイルス感染の概要 overview of hepatitis a virus infection in children
4. 性器単純ヘルペスウイルス感染の疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of genital herpes simplex virus infection
5. 新生児単純ヘルペスウイルス感染：臨床的特徴および診断 neonatal herpes simplex virus infection clinical features and diagnosis

English Journal

Transcriptome and miRNA network analysis of familial hypercholesterolemia.

Chen H1, Wang L2, Jiang J1.Author information 1Department of Medical Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, P.R. China.2Department of Cardiovascular Surgery, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.AbstractFamilial hypercholesterolemia (FH) is a genetic disorder characterized by a high serum concentration of low‑density lipoprotein (LDL) cholesterol. The high LDL cholesterol level leads to an excess deposition of cholesterol in the arterial walls and accelerated atherosclerosis, thereby increasing the risk of premature coronary heart disease. In the present study, we used a DNA microarray approach to identify gene expression profiles that distinguish patients with FH from healthy control subjects. Furthermore, transcription factors (TFs), microRNAs (miRNAs), target genes and pathways were analyzed to explore the potential transcriptional interactions occurring in FH. Publicly available microarray and regulation data were used to construct a regulatory network to identify additional genes related to FH and their interactions. The results revealed that specificity protein 1 (SP1), signal transducer and activator of transcription 1 (STAT1) and spleen focus forming virus (SFFV) proviral integration oncogene spi1 (SPI1) play a central role in the FH regulatory network. In addition, the TF, upstream transcription factor 2, c-fos interacting (USF2) and the gene, Wiskott-Aldrich syndrome (WAS), were identified to be associated with FH, although no reports for these proteins exist in the literature. Overall, transcriptional network analysis proved to be effective approach to identify novel targets for FH therapy.
International journal of molecular medicine.Int J Mol Med.2014 Mar;33(3):670-6. doi: 10.3892/ijmm.2013.1610. Epub 2013 Dec 27.
Familial hypercholesterolemia (FH) is a genetic disorder characterized by a high serum concentration of low‑density lipoprotein (LDL) cholesterol. The high LDL cholesterol level leads to an excess deposition of cholesterol in the arterial walls and accelerated atherosclerosis, thereby increasing t
PMID 24378567

Wnt/β-catenin signaling regulates follicular development by modulating the expression of Foxo3a signaling components.

Li L1, Ji SY1, Yang JL1, Li XX1, Zhang J1, Zhang Y1, Hu ZY2, Liu YX3.Author information 1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Graduate School of the Chinese Academy of Sciences, Beijing 100049, China.2State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.3State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: liuyx@ioz.ac.cn.AbstractWnt signaling is an evolutionarily conserved pathway that regulates cell proliferation, differentiation and apoptosis. To investigate the possible role of Wnt signaling in the regulation of ovarian follicular development, secondary follicles were isolated and cultured in vitro in the presence or absence of its activator (LiCl or Wnt3a) or inhibitor (IWR-1). We have demonstrated that activation of β-catenin signals by activators dramatically suppressed follicular development by increasing granulosa cell apoptosis and inhibiting follicle steroidogenesis. In contrast, inhibition of Wnt signaling by IWR-1 was observed with better developed follicles and increased steroidogenesis. Further studies have shown that the transcription factor Forkhead box O3a (Foxo3a) and its downstream target molecules were modulated by the activators or the inhibitor. These findings provide evidence that Wnt signaling might negatively regulate follicular development potentially through Foxo3a signaling components.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Feb 15;382(2):915-25. doi: 10.1016/j.mce.2013.11.007. Epub 2013 Nov 15.
Wnt signaling is an evolutionarily conserved pathway that regulates cell proliferation, differentiation and apoptosis. To investigate the possible role of Wnt signaling in the regulation of ovarian follicular development, secondary follicles were isolated and cultured in vitro in the presence or abs
PMID 24246780

Tailoring the surface properties of tobacco mosaic virions by the integration of bacterially expressed mutant coat protein.

Eiben S1, Stitz N2, Eber F3, Wagner J4, Atanasova P5, Bill J6, Wege C7, Jeske H8.Author information 1Institute of Biology, Universität Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany. Electronic address: sabine.eiben@bio.uni-stuttgart.de.2Institute of Materials Science, Universität Stuttgart, Heisenbergstr. 3, 70569 Stuttgart, Germany. Electronic address: stitz@imw.uni-stuttgart.de.3Institute of Biology, Universität Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany. Electronic address: Fabian.j.Eber@gmail.com.4Institute of Materials Science, Universität Stuttgart, Heisenbergstr. 3, 70569 Stuttgart, Germany.5Institute of Materials Science, Universität Stuttgart, Heisenbergstr. 3, 70569 Stuttgart, Germany. Electronic address: atanasova@imw.uni-stuttgart.de.6Institute of Materials Science, Universität Stuttgart, Heisenbergstr. 3, 70569 Stuttgart, Germany. Electronic address: bill@imw.uni-stuttgart.de.7Institute of Biology, Universität Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany. Electronic address: christina.wege@bio.uni-stuttgart.de.8Institute of Biology, Universität Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany. Electronic address: holger.jeske@bio.uni-stuttgart.de.AbstractDue to its small dimensions and high stability, tobacco mosaic virus (TMV) is used as nano-scaffold frequently. Its surface can be engineered to meet specific needs for technical, medical or materials applications. However, not all technically desirable TMV coat protein (CP) mutants can be propagated in plants successfully, if they change the efficiency of virion assembly. In order to circumvent this problem, a novel wild type (wt) CP-assisted and RNA-directed assembly procedure was designed for a recalcitrant CP mutant: Although pure hexahistidine-tagged CP cannot form particles on its own with TMV RNA in vitro, it was integrated into full-length particles if blended with wt CP in different proportions. The resulting rods formed dense monolayers with short range alignment on silicon substrates, substantially different from the largely wavy patterns obtained with wt TMV. Since they also mediated efficient ZnO deposition under mild conditions, the approach has yielded a new class of biotemplates which are amenable to the formation of nanostructured hybrid materials with adjustable texture for various applications.
Virus research.Virus Res.2014 Feb 13;180:92-6. doi: 10.1016/j.virusres.2013.11.019. Epub 2013 Dec 1.
Due to its small dimensions and high stability, tobacco mosaic virus (TMV) is used as nano-scaffold frequently. Its surface can be engineered to meet specific needs for technical, medical or materials applications. However, not all technically desirable TMV coat protein (CP) mutants can be propagate
PMID 24299619

Japanese Journal

Detection of monoclonal integration of bovine leukemia virus proviral DNA as a malignant marker in two enzootic bovine leukosis cases with difficult clinical diagnosis

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Journal of Veterinary Medical Science advpub(0), 2015
… Monoclonal integration of bovine leukemia virus (BLV) proviral DNA into bovine genomes was detected in peripheral blood from two clinical cases of enzootic bovine leukosis (EBL) without enlargement of superficial lymph nodes. … These results suggest that the detection of monoclonal integration of BLV provirus into the host genome may serve as a marker of monoclonal proliferation and malignancy in difficult to diagnose EBL cattle. …
NAID 130004781126

Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia–lymphoma cells

Taniguchi Hiroaki,Hasegawa Hiroo,Sasaki Daisuke,Ando Koji,Sawayama Yasushi,Imanishi Daisuke,Taguchi Jun,Imaizumi Yoshitaka,Hata Tomoko,Tsukasaki Kunihiro,Uno Naoki,Morinaga Yoshitomo,Yanagihara Katsunori,Miyazaki Yasushi
Cancer Science 105(12), 1601-1608, 2014-12-01
… Interestingly, AUY922 induced downregulation of the proviral integration site for Moloney murine leukemia virus (PIM) in ATL cells. …
NAID 120005526601

Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression

Li Ying-Yi,Mukaida Naofumi
World Journal of Gastroenterology 20(28), 9392-9404, 2014-07-28
… Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus (Pim) family proteins that exhibit serine/threonine kinase activity. …
NAID 120005516434