vesicular glutamate transporter

• 小胞グルタミン酸輸送体、小胞グルタミン酸トランスポーター

関

vesicular glutamate transport protein、VGLUT

WordNet

1. move something or somebody around; usually over long distances
2. an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
3. move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
4. transport commercially (同)send, ship
5. a long truck for carrying motor vehicles (同)car transporter
6. a crane for moving material with dispatch as in loading and unloading ships
7. of or relating to or involving vesicles; "normal vesicular breathing"
8. a salt or ester of glutamic acid

PrepTutorEJDIC

1. (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
2. 自動車運搬用大型トラック
3. 小嚢の小胞の,小嚢(小胞)状の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/27 23:10:51」(JST)

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SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	MGI: 1920211 HomoloGene: 113454 GeneCards: SLC17A7
Gene ontology Molecular function • inorganic phosphate transmembrane transporter activity • sodium:inorganic phosphate symporter activity • extracellular-glutamate-gated chloride channel activity • symporter activity • L-glutamate transmembrane transporter activity • sodium-dependent phosphate transmembrane transporter activity Cellular component • postsynapse • integral component of membrane • membrane • synaptic vesicle • plasma membrane • synapse • excitatory synapse • synaptic vesicle membrane • cerebellar mossy fiber • presynaptic active zone • cell junction • intracellular organelle • neuron projection • clathrin-sculpted glutamate transport vesicle membrane • cytoplasmic vesicle • integral component of synaptic vesicle membrane Biological process • phosphate ion transport • synaptic transmission, glutamatergic • sodium-dependent phosphate transport • sodium ion transport • chloride transmembrane transport • ion transport • glutamate secretion • synaptic vesicle lumen acidification • brain development • long-term memory • excitatory postsynaptic potential • transport • neurotransmitter transport • neural retina development • L-glutamate import • sequestering of neurotransmitter • sodium ion transmembrane transport • transmembrane transport • chemical synaptic transmission • phosphate ion transmembrane transport • L-glutamate transmembrane transport • neurotransmitter loading into synaptic vesicle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57030	72961
Ensembl	ENSG00000104888	ENSMUSG00000070570
UniProt	Q9P2U7	Q3TXX4
RefSeq (mRNA)	NM_020309	NM_182993
RefSeq (protein)	NP_064705	NP_892038.2 NP_892038
Location (UCSC)	Chr 19: 49.43 – 49.44 Mb	Chr 7: 45.16 – 45.18 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.

See also

• Solute carrier family

References

Further reading

• Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.". Science. 289 (5481): 957–60. doi:10.1126/science.289.5481.957. PMID 10938000. 
• Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons.". Nature. 407 (6801): 189–94. doi:10.1038/35025070. PMID 11001057. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons.". Schizophrenia Research. 73 (2-3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. 
• Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex.". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236. 
• Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis.". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361. 
• Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters.". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMC 2206968 . PMID 17660252. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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English Journal

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Japanese Journal

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• NAID 120005767003

• The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways

• Biological and Pharmaceutical Bulletin 39(5), 770-777, 2016
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Related Pictures

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★リンクテーブル★

リンク元	「小胞グルタミン酸輸送体」「VGLUT」「小胞グルタミン酸トランスポーター」
拡張検索	「vesicular glutamate transporter 1」「vesicular glutamate transporter 2」
関連記事	「transport」「glutamate transporter」「glutamate」「transporter」「vesicular」

「小胞グルタミン酸輸送体」

　　[★]

英

vesicular glutamate transporter、VGLUT

関

小胞グルタミン酸輸送タンパク質、小胞グルタミン酸トランスポーター

「VGLUT」

　　[★]

• 小胞グルタミン酸輸送体

関

vesicular glutamate transport protein、vesicular glutamate transporter

「小胞グルタミン酸トランスポーター」

　　[★]

英

vesicular glutamate transporter

関

小胞グルタミン酸輸送体

「vesicular glutamate transporter 1」

　　[★]

• 小胞グルタミン酸輸送体1、小胞グルタミン酸トランスポーター1

関

vesicular glutamate transport protein 1、VGLUT1

「vesicular glutamate transporter 2」

　　[★]

• 小胞グルタミン酸輸送体2、小胞グルタミン酸トランスポーター2

関

vesicular glutamate transport protein 2、VGLUT2

「transport」

　　[★]

• n.

• 輸送、運搬

• v.

• 輸送する、運搬する、運ぶ

関

bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

　 　 　 　 　

「glutamate transporter」

　　[★]

• グルタミン酸トランスポーター、グルタミン酸輸送体

関

amino acid transport system X-AG、glutamate-aspartate transporter

「glutamate」

　　[★]

グルタミン酸、グルタメート、グルタメイト、(化合物)グルタミン酸塩

　

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein

　 　 　

「vesicular」

　　[★]

• adj.

• 小胞の

関

vesicle