- adj.
- 単層の
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/16 11:14:36」(JST)
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- 1. 内臓リーシュマニア症の治療 treatment of visceral leishmaniasis
English Journal
- Design and in vitro characterization of small unilamellar niosomes as ophthalmic carrier of dorzolamide hydrochloride.
- Hasan AA.Author information Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University , Al-Ahsa, Hufof , Saudi Arabia and.AbstractThe objective of this work was to formulate and characterize non-ionic surfactant vesicles (niosomes) as an ocular carrier of dorzolamide hydrochloride (Dorzo); one of the antiglaucoma drugs. Niosomes were prepared of Cholesterol (Chol) with sorbitan monoesters (Span 20, 40, 60) or sorbitan trioleate (Span 85) in a molar ratio of 40:150. Those prepared from Span 40 were selected for further investigation on the effect of addition of dicetylphosphate (DCP) and polyoxyethylene fatty acid esters (either Tween 20, 40 or 80). All The batches were prepared using mechanical shaking technique, followed by sonication and then characterized using Zetasizer, transmission electron microscopy (TEM), calculating percent drug entrapment efficiency and cumulative percent released. Z-average sizes of the niosomes were between 25.9 and 165.5 nm. All niosomal formulations showed negative zeta potential charge. Dorzo was successfully entrapped in all of the formulations with entrapment efficiencies ranging between 34.81% and 97.66%. With reference to release profiles, Dorzo-loaded niosomal formulations showed significant reduction in cumulative percent drug released than Dorzo solution. High entrapment efficiencies, biphasic prolonged release rate and small particles size highlight Dorzo-loaded niosomal preparations as a promising ophthalmic carrier to prolong the drug lowering effect on the intraocular pressure.
- Pharmaceutical development and technology.Pharm Dev Technol.2014 Sep;19(6):748-54. doi: 10.3109/10837450.2013.829095. Epub 2013 Aug 22.
- The objective of this work was to formulate and characterize non-ionic surfactant vesicles (niosomes) as an ocular carrier of dorzolamide hydrochloride (Dorzo); one of the antiglaucoma drugs. Niosomes were prepared of Cholesterol (Chol) with sorbitan monoesters (Span 20, 40, 60) or sorbitan trioleat
- PMID 23964893
- Coexistence of two liquid crystalline phases in dihydrosphingomyelin and dioleoylphosphatidylcholine binary mixtures.
- Kinoshita M1, Matsumori N2, Murata M3.Author information 1JST ERATO, Lipid Active Structure Project, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Project Research Center for Fundamental Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan. Electronic address: kinoshi@chem.sci.osaka-u.ac.jp.2JST ERATO, Lipid Active Structure Project, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.3JST ERATO, Lipid Active Structure Project, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Project Research Center for Fundamental Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan. Electronic address: murata@chem.sci.osaka-u.ac.jp.AbstractRecently, DHSM, a minor constituent in naturally occurring SMs, was indicated to form a raft-like ordered phase more effectively than a naturally occurring form of SM because DHSM has greater potential to induce the intermolecular hydrogen bond. In order to examine the influence of the DHSM-induced hydrogen bond on the phase segregation, the thermal phase behavior of stearoyl-DHSM/DOPC binary bilayers was examined using calorimetry and fluorescence observation and compared with that of SSM/DOPC binary bilayers. Results revealed that the DHSM/DOPC bilayers undergo phase segregation between two Lα phases within a limited compositional range. On the other hand, apparent phase separation was not observed above main transition temperature in SSM/DOPC mixtures. Our monolayer measurements showed that the lipid packing of DHSM is less perturbed than that of SSM by the addition of small amount of DOPC, indicating a stronger hydrogen bond between DHSM molecules. Therefore, in DHSM/DOPC binary bilayers, DHSM molecules may locally accumulate to form a DHSM-rich domain due to a DHSM-induced hydrogen bond. On the other hand, excess accumulation of DHSM should be prevented because the difference in the curvature between DHSM and DOPC assemblies causes elastic constraint at the domain boundary between the DHSM-rich and DOPC-rich domains. Competition between the energetic advantages provided by formation of the hydrogen bond and the energetic disadvantage conferred by elastic constraints likely results in Lα/Lα phase separation within a limited compositional range.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 May;1838(5):1372-81. doi: 10.1016/j.bbamem.2014.01.017. Epub 2014 Jan 24.
- Recently, DHSM, a minor constituent in naturally occurring SMs, was indicated to form a raft-like ordered phase more effectively than a naturally occurring form of SM because DHSM has greater potential to induce the intermolecular hydrogen bond. In order to examine the influence of the DHSM-induced
- PMID 24468063
- Cell-free synthesis of membrane proteins: Tailored cell models out of microsomes.
- Fenz SF1, Sachse R2, Schmidt T1, Kubick S3.Author information 1Leiden Institute of Physics, Leiden University, PO Box 9504, 2300 RA Leiden, The Netherlands.2Fraunhofer IBMT, Branch Potsdam-Golm, Group of Cell-free Protein Synthesis, Am Mühlenberg 13, 14476 Potsdam, Germany.3Fraunhofer IBMT, Branch Potsdam-Golm, Group of Cell-free Protein Synthesis, Am Mühlenberg 13, 14476 Potsdam, Germany. Electronic address: Stefan.Kubick@ibmt.fraunhofer.de.AbstractIncorporation of proteins in biomimetic giant unilamellar vesicles (GUVs) is one of the hallmarks towards cell models in which we strive to obtain a better mechanistic understanding of the manifold cellular processes. The reconstruction of transmembrane proteins, like receptors or channels, into GUVs is a special challenge. This procedure is essential to make these proteins accessible to further functional investigation. Here we describe a strategy combining two approaches: cell-free eukaryotic protein expression for protein integration and GUV formation to prepare biomimetic cell models. The cell-free protein expression system in this study is based on insect lysates, which provide endoplasmic reticulum derived vesicles named microsomes. It enables signal-induced translocation and posttranslational modification of de novo synthesized membrane proteins. Combining these microsomes with synthetic lipids within the electroswelling process allowed for the rapid generation of giant proteo-liposomes of up to 50μm in diameter. We incorporated various fluorescent protein-labeled membrane proteins into GUVs (the prenylated membrane anchor CAAX, the heparin-binding epithelial growth factor like factor Hb-EGF, the endothelin receptor ETB, the chemokine receptor CXCR4) and thus presented insect microsomes as functional modules for proteo-GUV formation. Single-molecule fluorescence microscopy was applied to detect and further characterize the proteins in the GUV membrane. To extend the options in the tailoring cell models toolbox, we synthesized two different membrane proteins sequentially in the same microsome. Additionally, we introduced biotinylated lipids to specifically immobilize proteo-GUVs on streptavidin-coated surfaces. We envision this achievement as an important first step toward systematic protein studies on technical surfaces.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 May;1838(5):1382-8. doi: 10.1016/j.bbamem.2013.12.009. Epub 2013 Dec 25.
- Incorporation of proteins in biomimetic giant unilamellar vesicles (GUVs) is one of the hallmarks towards cell models in which we strive to obtain a better mechanistic understanding of the manifold cellular processes. The reconstruction of transmembrane proteins, like receptors or channels, into GUV
- PMID 24370776
Japanese Journal
- スモールユニラメラベシクル(SUV)のMDシミュレーションから脂質膜の弾性係数の曲率依存性を計算する手法
- 中村 壮伸
- アンサンブル : 分子シミュレーション研究会会誌 15(4), 230-236, 2013-10
- NAID 40019845923
- Improved membrane fluidity of ionic polysaccharide bead-supported phospholipid bilayer membrane systems
- Haratake Mamoru,Takahira Ekuko,Yoshida Sakura,Osei-Asante Samuel,Fuchigami Takeshi,Nakayama Morio
- Colloids and Surfaces B: Biointerfaces 107, 90-96, 2013-07-01
- … Supported phospholipid bilayer membranes on polysaccharide-based cationic polymer beads (cationic group: -[OCH2CH(OH)CH2]2N+(CH3)3·X-, 45-165μm in diameter) were prepared using small unilamellar vesicles from mixtures of phosphatidylserine (PS) and phosphatidylcholine (PC). … The lateral diffusion coefficients (D) for the PS/PC-bead complexes were lower than that for the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine giant unilamellar vesicles without solid supports. …
- NAID 120005231014
- Fluorescence microscopic characterization of ionic polymer bead-supported phospholipid bilayer membrane systems
- Haratake Mamoru,Osei-Asante Samuel,Fuchigami Takeshi,Nakayama Morio
- Colloids and Surfaces B: Biointerfaces 100, 190-196, 2012-12-01
- … The lateral diffusion coefficients (D) for the PS/PC-bead complexes were one-half or less than that for 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine giant unilamellar vesicles without solid supporting materials. …
- NAID 120005231015
Related Links
- unilamellar (biology) Having a single layer or lamella. Retrieved from "https://en.wiktionary.org/w/index.php?title=unilamellar&oldid=21161725" Categories: English lemmas English adjectives en:Biology Navigation menu Log in ...
- unilamellar の発音 再生されない時は こちら をクリックしてください Copyright 2013 ライフサイエンス辞書プロジェクト ...
Related Pictures
★リンクテーブル★
| リンク元 | 「monolayer」「単層」 |
| 拡張検索 | 「unilamellar vesicle」「unilamellar liposome」 |
「monolayer」
「単層」
- 英
- monolayer、unilamellar
- 関
- 単分子膜