関: trimebutine maleate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/08 14:27:59」(JST)

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Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.^[1] The maleic acid salt of trimebutine is marketed under the trademark of Debridat, Recutin, Polybutin,^[2] or Modulon for treatment of irritable bowel syndrome and other gastrointestinal disorders. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine,^[3] which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract.^[4] Both Trimebutine and its metabolite are commercially available.

References[edit]

^ Kaneto H, Takahashi M, Watanabe J. The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. Journal of Pharmacobiodynamics. 1990 Jul;13(7):448-53. PMID 1963196
^ Ok Hwa Jhee, Yun Sik Lee, Leslie M. Shaw, Yong Cheol Jeon, Min Ho Lee, Seung Hoon Lee and Ju Seop Kang The Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC–MS/MS method. Clinica Chimica Acta. 2007 Jan;375(1-2):69-75. PMID 16854404
^ F.J. Roman, S. Lanet, J. Hamon, G. Brunelle, A. Maurin, P. Champeroux, S. Richard, N. Alessandri, and M. Gola Pharmacological Properties of Trimebutine and N-Monodesmethyltrimebutine. The Journal of Pharmacology and Experimental Therapeutics 1999;289:1391–1397. PMID 10336531
^ Hiyama, T.; Yoshihara, M.; Tanaka, S.; Haruma, K.; Chayama, K. (Apr 2009). "Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract.". J Gastroenterol Hepatol 24 (4): 537–46. doi:10.1111/j.1440-1746.2009.05780.x. PMID 19220673.

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1. 成人における過敏性腸症候群の治療 treatment of irritable bowel syndrome in adults

English Journal

End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression.

Lee SH, Lee JH, Cho S, Do SH, Woo YA.SourceKorea United Pharm. Inc., Chungnam, 339-841, Korea.
Archives of pharmacal research.Arch Pharm Res.2012 Sep;35(9):1599-607. doi: 10.1007/s12272-012-0911-3. Epub 2012 Oct 9.
This study showed near Infrared (NIR) and Raman spectroscopy with a multivariate calibration approach were very effective to determine blend uniformity end-point. A set of 36 trimebutine samples containing magnesium stearate, stearic acid, colloidal silicon oxide, talc as excipients (0.9%∼1.8%) wa
PMID 23054717

[Potential severity of self-poisoning with trimebutine].

Glaizal M, Alunni V, Arzalier JJ, Page G, Gaillard Y, Piercecchi-Marti MD, Hayek-Lanthois M, de Haro L.
Presse médicale (Paris, France : 1983).Presse Med.2012 Jun;41(6 Pt 1):662-3. doi: 10.1016/j.lpm.2011.10.010. Epub 2011 Dec 1.
PMID 22137289

Japanese Journal

A Case of Trimebutine-Induced Anaphylaxis

Allergology International 60(4), 555-556, 2011
NAID 130004477120

Inhibitory Effects of Ramosetron, a Potent and Selective 5-HT_3-Receptor Antagonist, on Conditioned Fear Stress-Induced Abnormal Defecation and Normal Defecation in Rats : Comparative Studies With Antidiarrheal and Spasmolytic Agents

Journal of pharmacological sciences 106(2), 264-270, 2008-02-20
NAID 10024318406

シェーグレン症候群患者の口腔乾燥症治療における塩酸セビメリン水和物の副作用発現とその予防に関する臨床的検討

日本口腔科学会雑誌 55(4), 246-252, 2006
NAID 130004335948

「トリメブチン」

Trimebutine
Systematic (IUPAC) name
	2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	39133-31-8
ATC code	A03AA05
PubChem	CID 5573
UNII	QZ1OJ92E5R
ChEMBL	CHEMBL190044
Chemical data
Formula	C22H29NO5
Mol. mass	387.47 g/mol
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