transmembrane segment

• 膜貫通領域

関

TM domain、TMR、transmembrane domain、transmembrane region

WordNet

1. divide or split up; "The cells segmented"
2. one of the parts into which something naturally divides; "a segment of an orange"
3. divide into segments; "segment an orange"; "segment a compound word" (同)section

PrepTutorEJDIC

1. 区分,部分 / 切片(円などの一部);(直線の)線分 / …‘を'分ける / 分かれている,分裂する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/22 11:08:28」(JST)

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[Wiki en表示]

Transmembrane segment usually denotes a single transmembrane alpha helix of a transmembrane protein, also known as an integral protein. More broadly, a transmembrane segment is any three-dimensional protein structure which is thermodynamically stable in a membrane. This may be a single alpha helix, a transmembrane beta barrel, a beta-helix of gramicidin A, or any other structure. Transmembrane helices are usually about 20 amino acids in length.

Identification of transmembrane helices

Transmembrane helices are visible in structures of membrane proteins determined by X-ray diffraction. They may also be predicted on the basis of hydrophobicity scales. Because the interior of the bilayer and the interiors of most proteins of known structure are hydrophobic, it is presumed to be a requirement of the amino acids that span a membrane that they be hydrophobic as well. However, membrane pumps and ion channels also contain numerous charged and polar residues within the generally non-polar transmembrane segments.

Using hydrophobicity analysis to predict transmembrane helices enables a prediction in turn of the "transmembrane topology" of a protein; i.e. prediction of what parts of it protrude into the cell, what parts protrude out, and how many times the protein chain crosses the membrane. Such prediction methods are commonly applied with a limited success.

Online transmembrane prediction algorithm servers are listed by Expasy [1] under Topology prediction. The resulting predictions often differ and should be used with caution.

References

UpToDate Contents

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• 1. ST上昇型心筋梗塞における血栓溶解療法：効果の指標 fibrinolytic thrombolytic agents in acute st elevation myocardial infarction markers of efficacy
• 2. 心電図チュートリアル：心筋虚血および心筋梗塞 ecg tutorial myocardial ischemia and infarction
• 3. 心筋梗塞または不安定狭心症の予後における心電図 electrocardiogram in the prognosis of myocardial infarction or unstable angina
• 4. 心筋虚血および心筋梗塞の診断における心電図 electrocardiogram in the diagnosis of myocardial ischemia and infarction
• 5. 不安定狭心症および非ST上昇型心筋梗塞の分類 classification of unstable angina and non st elevation myocardial infarction

English Journal

• A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport.

• Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, Defelice LJ, Meiler J, Blakely RD.SourceFrom the Departments of Pharmacology.
• The Journal of biological chemistry.J Biol Chem.2011 Sep 2;286(35):30823-36. Epub 2011 Jul 5.
• Na(+)- and Cl(-)-dependent uptake of neurotransmitters via transporters of the SLC6 family, including the human serotonin transporter (SLC6A4), is critical for efficient synaptic transmission. Although residues in the human serotonin transporter involved in direct Cl(-) coordination of human seroton
• PMID 21730057

• Robust post-translocational N-glycosylation at the extreme C-terminus of membrane and secreted proteins in Xenopus laevis oocytes and HEK293 cells.

• Pult F, Fallah G, Braam U, Detro-Dassen S, Niculescu C, Laube B, Schmalzing G.SourceDepartment of Molecular Pharmacology, RWTH Aachen University of Aachen, Wendlingweg 2, D-52074 Aachen, Germany.
• Glycobiology.Glycobiology.2011 Sep;21(9):1147-60. Epub 2011 Feb 8.
• N-Glycosylation is normally a co-translational process that occurs as soon as a nascent and unfolded polypeptide chain has emerged ?12 residues into the lumen of the endoplasmic reticulum (ER). Here, we describe the efficient utilization of an N-glycosylation site engineered within the luminal ext
• PMID 21303814

Japanese Journal

• 電位依存性プロトンチャネルに見る膜電位センサーの謎：細胞膜中に存在する電荷

• 黒川 竜紀,岡村 康司
• 生物物理 51(2), 072-075, 2011
• … The voltage-sensor domain (VSD) is the key module for voltage sensing of transmembrane proteins. … The fourth transmembrane segment (S4) of VSOP contains three arginines (R1, R2, R3). …
• NAID 130000645360

• ミトコンドリア内膜のADP/ATP透過担体のC末端領域の構造特性と機能

• 篠原 康雄,橋本 満,木平 孝高,大倉 一人,真島 英司,寺田 弘
• YAKUGAKU ZASSHI 130(2), 199-204, 2010
• … Furthermore, based on the reactivities of cysteine residues that replaced amino acids in the sixth transmembrane segment, the probable structural features of the C-terminal region of this carrier are discussed. …
• NAID 130000171288

Related Links

• Transmembrane domain - Wikipedia, the free encyclopedia

However, membrane pumps and ion channels also contain numerous charged and polar residues within the generally non-polar transmembrane segments. Using hydrophobicity analysis to predict transmembrane helices enables a prediction ...

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★リンクテーブル★

リンク元	「TMR」「transmembrane domain」「transmembrane region」「TM domain」
関連記事	「segment」「transmembrane」

「TMR」

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• 膜貫通領域、((略))(薬品)トラメチルローダミン

関

tetramethylrhodamine、TM domain、transmembrane domain、transmembrane region、transmembrane segment

「transmembrane domain」

　　[★]

膜貫通領域、膜貫通ドメイン

関

membrane-spanning domain、MSD、TM domain、TMR、transmembrane region、transmembrane segment

「transmembrane region」

　　[★]

膜貫通領域、膜貫通部、膜貫通部位

関

TM domain、TMR、transmembrane domain、transmembrane segment

「TM domain」

　　[★]

• 膜貫通領域、膜貫通部位

関

TMR、transmembrane domain、transmembrane region、transmembrane segment

「segment」

　　[★]

• n.

• セグメント、区域、分節、体節

関

area、metameric、region、segmental、somite、somitic

　 　 　 　

「transmembrane」

　　[★]

• 膜貫通の、膜貫通型の

関

membrane-spanning、TM、transmembranous