transmembrane domain

膜貫通領域、膜貫通ドメイン

関

membrane-spanning domain、MSD、TM domain、TMR、transmembrane region、transmembrane segment

WordNet

1. territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
2. (mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function

PrepTutorEJDIC

1. (国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/18 18:36:28」(JST)

wiki en

[Wiki en表示]

Transmembrane domain usually denotes a single transmembrane alpha helix of a transmembrane protein. Also known as an integral protein. More broadly, a transmembrane domain is any three-dimensional protein structure which is thermodynamically stable in a membrane. This may be a single alpha helix, a stable complex of several transmembrane alpha helices, a transmembrane beta barrel, a beta-helix of gramicidin A, or any other structure. Transmembrane helices are usually about 20 amino acids in length.

Identification of transmembrane helices

Transmembrane helices are visible in structures of membrane proteins determined by X-ray diffraction. They may also be predicted on the basis of hydrophobicity scales. Because the interior of the bilayer and the interiors of most proteins of known structure are hydrophobic, it is presumed to be a requirement of the amino acids that span a membrane that they be hydrophobic as well. However, membrane pumps and ion channels also contain numerous charged and polar residues within the generally non-polar transmembrane segments.

Using hydrophobicity analysis to predict transmembrane helices enables a prediction in turn of the "transmembrane topology" of a protein; i.e. prediction of what parts of it protrude into the cell, what parts protrude out, and how many times the protein chain crosses the membrane. Such prediction methods are commonly applied with a limited success.

Online transmembrane prediction algorithm servers are listed by Expasy [1] under Topology prediction. The resulting predictions often differ and should be used with caution.

References

UpToDate Contents

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• 1. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 2. 多発性内分泌腫瘍2型の分類および遺伝学 classification and genetics of multiple endocrine neoplasia type 2
• 3. 前立腺癌の分子生物学 molecular biology of prostate cancer
• 4. 膜性腎症の原因および診断 causes and diagnosis of membranous nephropathy
• 5. 自己免疫性リンパ増殖症候群(ALPS)：疫学および病因 autoimmune lymphoproliferative syndrome alps epidemiology and pathogenesis

English Journal

• Identification, expression profiling of a grass carp TLR8 and its inhibition leading to the resistance to reovirus in CIK cells.

• Chen X, Wang Q, Yang C, Rao Y, Li Q, Wan Q, Peng L, Wu S, Su J.SourceCollege of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, China.
• Developmental and comparative immunology.Dev Comp Immunol.2013 Sep;41(1):82-93. doi: 10.1016/j.dci.2013.04.015. Epub 2013 Apr 28.
• TLR8 (toll-like receptor 8), a homolog of TLR3, TLR7 and TLR9 as prototypical intracellular members of TLR family, is generally associated with sensing single stranded RNA and plays a pivotal role in antiviral immune response. In this study, a TLR8 gene from grass carp Ctenopharyngodon idella (desig
• PMID 23632252

• Molecular and cellular analyses of a ryanodine receptor from hemocytes of Pieris rapae.

• Wu S, Wang F, Huang J, Fang Q, Shen Z, Ye G.SourceState Key Laboratory of Rice Biology, Key Laboratory of Agricultural Entomology of Ministry of Agriculture, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China.
• Developmental and comparative immunology.Dev Comp Immunol.2013 Sep;41(1):1-10. doi: 10.1016/j.dci.2013.04.006. Epub 2013 Apr 19.
• Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum membrane and are a distinct class of ligand-gated calcium channels controlling the release of calcium from intracellular stores. Intracellular calcium level has a definite role in innate and adaptive immune signaling. H
• PMID 23603125

• Assembling viral channel forming proteins: Vpu from HIV-1.

• Li LH, Hsu HJ, Fischer WB.SourceInstitute of Biophotonics, School of Biomedical Science and Engineering and Biophotonics and Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan.
• Biopolymers.Biopolymers.2013 Aug;99(8):517-29. doi: 10.1002/bip.22210.
• Different routes of assembly are probed for the transmembrane domain (TMD) of the bitopic membrane protein Vpu from HIV-1. Vpu is responsible for the amplification of viral release from the host cell. The mode of action includes (i) heteroassembly with host factors and (ii) the formation of homo-oli
• PMID 23712488

Japanese Journal

• Agonistic Antibodies Reveal the Function of GPR56 in Human Glioma U87-MG Cells

• Ohta Shigeyuki,Sakaguchi Sayaka,Kobayashi Yuki [他],Mizuno Norikazu,Tago Kenji,Itoh Hiroshi
• Biological and Pharmaceutical Bulletin 38(4), 594-600, 2015
• … Co-immunoprecipitation analysis indicated that the interaction between the GPR56 extracellular domain and transmembrane domain was potentiated by agonistic antibodies. …
• NAID 130005062265

• 膜内KcsAカリウムチャネルの原子間力顕微鏡による構造と動態解析

• 角野 歩,山本 大輔,炭竈 享司 [他],岩本 真幸,出羽 毅久,老木 成稔
• 生物物理 55(1), 005-010, 2015
• … The structure of the transmembrane pore-domain of the KcsA channel was examined using atomic force microscopy (AFM) under the membrane-embedded condition. … In the closed conformation, the cytoplasmic end of the pore domain was protruded from the membrane surface. …
• NAID 130004794734

• A case of isolated hypocalciuric hypercalcemia and type 2 diabetes mellitus followed by Grave's disease

• Tojikubo Masayuki,Akazawa Shoichi,Nakano Yuko,Nakamura Satoe,Yamashita Shunichi
• Acta medica Nagasakiensia 59(1), 27-31, 2014-07
• … The patient and her family members did not have any mutations in the extracellular domain or transmembrane domain of the calcium-sensing receptor, which has been reported to play an important role in Ca binding and intracellular signaling. …
• NAID 120005468239

Related Links

• Transmembrane domainとは - goo Wikipedia (ウィキペディア)

Transmembrane domain usually denotes a single transmembrane alpha helix of a transmembrane protein. It is called a "domain" because an alpha-helix in a membrane can fold independently from the rest of the protein, similar to domains of water-soluble proteins

• Transmembrane domain - definition of Transmembrane ...

do·main (d-m n) n. 1. A territory over which rule or control is exercised. 2. A sphere of activity, concern, or function; a field: the domain of history. See Synonyms at field. 3. Physics Any of numerous contiguous regions in a ...

• "DAS" - Transmembrane Prediction server

Miklos "DAS" - Transmembrane Prediction server For brief description of the method read the abstract. Please cite: M. Cserzo, E. Wallin, I. Simon, G. von Heijne and A. Elofsson: Prediction of transmembrane alpha-helices in ...

Related Pictures

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★リンクテーブル★

リンク元	「TMR」「transmembrane region」「TM domain」「transmembrane segment」「membrane-spanning domain」
関連記事	「domain」「transmembrane」「domains」

「TMR」

　　[★]

• 膜貫通領域、((略))(薬品)トラメチルローダミン

関

tetramethylrhodamine、TM domain、transmembrane domain、transmembrane region、transmembrane segment

「transmembrane region」

　　[★]

膜貫通領域、膜貫通部、膜貫通部位

関

TM domain、TMR、transmembrane domain、transmembrane segment

「TM domain」

　　[★]

• 膜貫通領域、膜貫通部位

関

TMR、transmembrane domain、transmembrane region、transmembrane segment

「transmembrane segment」

　　[★]

• 膜貫通領域

関

TM domain、TMR、transmembrane domain、transmembrane region

「membrane-spanning domain」

　　[★]

• 膜貫通ドメイン、膜通過ドメイン

関

MSD、transmembrane domain

「domain」

　　[★]

• n.

• ドメイン、(分子内の)領域、分域

関

area、realm、region、regional、segregation、territory、universe

　 　 　

「transmembrane」

　　[★]

• 膜貫通の、膜貫通型の

関

membrane-spanning、TM、transmembranous

「domains」

　　[★]

関

See also specific type