関: tetrahydrozoline、tetrahydrozoline hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/01 17:39:09」(JST)

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Tetrahydrozoline (INN: Tetryzoline), a derivative of imidazoline, is found in over-the-counter eye drops and nasal sprays. Other derivatives include naphazoline, oxymetazoline, and xylometazoline.

Tetrahydrozoline is an alpha agonist and its main mechanism of action is the constriction of conjunctival blood vessels.^[1] This serves to relieve the redness of the eye caused by minor ocular irritants.

An urban legend suggests that tetrahydrozoline can cause violent diarrhea if administered orally, such as by putting a few drops of Visine in an unsuspecting person's beverage. However, the actual results of the "Visine Prank" may be worse, varying from severe nausea and vomiting to seizures or a coma. Diarrhea is not a side effect.^[2]

References

^ Dahlström M; Lindgren F; Berntsson K et al. (July 2005). "Evidence for different pharmacological targets for imidazoline compounds inhibiting settlement of the barnacle Balanus improvisus". J. Exp. Zoolog. Part a Comp. Exp. Biol. 303 (7): 551–62. doi:10.1002/jez.a.163. PMID 15945078.
^ "Visine Prank: Mickey Red Eyes". Snopes. 29 June 2009. Retrieved 28 July 2010.

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English Journal

Determination of antazoline and tetrahydrozoline in ophthalmic solutions by capillary electrophoresis and stability-indicating HPLC methods.

Gumustas M1, Alshana U2, Ertas N3, Goger NG3, Ozkan SA1, Uslu B4.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2016 May 30;124:390-8. doi: 10.1016/j.jpba.2016.02.032. Epub 2016 Feb 27.
Capillary electrophoretic (CE) and high performance liquid chromatographic (HPLC) methods were developed and optimized for the determination of antazoline (ANT) and tetrahydrozoline (TET) in ophthalmic formulations. Optimum electrophoretic conditions were achieved using a background electrolyte of 2
PMID 26952922

Comparative study between recent methods manipulating ratio spectra and classical methods based on two-wavelength selection for the determination of binary mixture of antazoline hydrochloride and tetryzoline hydrochloride.

Abdel-Halim LM1, Abd-El Rahman MK2, Ramadan NK2, El Sanabary HF3, Salem MY2.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2016 Apr 15;159:98-105. doi: 10.1016/j.saa.2016.01.014. Epub 2016 Jan 13.
A comparative study was developed between two classical spectrophotometric methods (dual wavelength method and Vierordt's method) and two recent methods manipulating ratio spectra (ratio difference method and first derivative of ratio spectra method) for simultaneous determination of Antazoline hydr
PMID 26836449

Stability-Indicating RP-HPLC Methods for the Determination of Fluorometholone in Its Mixtures with Sodium Cromoglycate and Tetrahydrozoline Hydrochloride.

El-Bagary RI1, Fouad MA2, El-Shal MA3, Tolba EH3.
Journal of chromatographic science.J Chromatogr Sci.2016 Feb 26. pii: bmw022. [Epub ahead of print]
Two stability-indicating reversed-phase liquid chromatographic methods were developed and validated for the determination of fluorometholone (FLU) in its mixtures with sodium cromoglycate (SCG) and tetrahydrozoline hydrochloride (THZ). The first HPLC method (Method 1) was based on isocratic elution
PMID 26921897

「tetrahydrozoline」

Tetrahydrozoline
Names
	IUPAC name (RS)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
Identifiers
CAS Registry Number	84-22-0
ATC code	R01AA06; S01GA02
ChEBI	CHEBI:28674
ChEMBL	ChEMBL1266
ChemSpider	5226
	InChI InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15) ; Key: BYJAVTDNIXVSPW-UHFFFAOYSA-N ; InChI=1/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15); Key: BYJAVTDNIXVSPW-UHFFFAOYAC ;
Jmol-3D images	Image
KEGG	D08578
PubChem	5419
	SMILES N\1=C(\NCC/1)C3c2ccccc2CCC3 ;
UNII	S9U025Y077
Properties
Chemical formula	C13H16N2
Molar mass	200.28 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references