English Journal

Target-Specific Ligands and Gadolinium-Based Complexes for Imaging of Dopamine Receptors: Synthesis, Binding Affinity, and Relaxivity.

Zigelboim I, Weissberg A, Cohen Y.SourceSchool of Chemistry, the Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University , Ramat Aviv, Tel-Aviv 69978, Israel.
The Journal of organic chemistry.J Org Chem.2013 Jul 9. [Epub ahead of print]
Magnetic resonance imaging (MRI) and positron emission tomography (PET) are two extremely important imaging modalities with unlimited tissue penetration. Molecular imaging is a field by which specific targets or biological processes are imaged. MRI, which is used for functional imaging and for the d
PMID 23777225

Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.

Gopishetty B, Zhang S, Kharkar PS, Antonio T, Reith M, Dutta AK.SourceWayne State University, Department of Pharmaceutical Sciences, 259 Mack Ave, Detroit, MI 48202, USA.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Jun 1;21(11):3164-74. doi: 10.1016/j.bmc.2013.03.059. Epub 2013 Apr 1.
The goal of the present study was to explore, in our previously developed hybrid template, the effect of introduction of additional heterocyclic rings (mimicking catechol hydroxyl groups as bioisosteric replacement) on selectivity and affinity for the D3 versus D2 receptor. In addition, we wanted to
PMID 23623679

French AN, Ashby RS, Morgan IG, Rose KA.SourceDiscipline of Orthoptics, Faculty of Health Sciences, University of Sydney, Lidcombe, NSW 2011, Australia.
Experimental eye research.Exp Eye Res.2013 May 2. pii: S0014-4835(13)00106-1. doi: 10.1016/j.exer.2013.04.018. [Epub ahead of print]
Recent epidemiological evidence suggests that children who spend more time outdoors are less likely to be, or to become myopic, irrespective of how much near work they do, or whether their parents are myopic. It is currently uncertain if time outdoors also blocks progression of myopia. It has been s
PMID 23644222

Japanese Journal

ANALYSIS OF BUTYROPHENONES IN WHOLE BLOOD SPECIMENS BY LC/MS/MS USING A NEW POLYMER COLUMN

Hattori Hideki,Arinobu Tetsuya,Iwai Masae,Masuda Kenji,Suzuki Osamu,Seno Hiroshi
2005-01-31
… The quantitation was made by mass chromatography for each product ion, The recoveries were more than 50% for haloperidol, bromperidol, moperone and spiroperidol at 80 ng/ml in whole blood, but less than 10% for pimozide. …
NAID 120005314065

谷垣範子 [他],萬野賢児,杉原邦夫,三木直正,市田成志,吉田博
日本薬理学雑誌 89(4), 175-180, 1987
… On the other hand, paroxetine showed almost no inhibitory action on the binding of the [3H]-labeled ligands examined in this study ([3H]quinuclidinyl benzilate, [3H]5-HT, [3H]ketanserine, [3H]pyrilamine, [3H]dihydroalprenolol, [3H]prazosin, [3H]clonidine and [3H]spiroperidol). …
NAID 130000759507

山脇泰秀
岡山医学会雑誌 94(3・4), p301-314, 1982-04-00
… In this study, the cross reactivities of numerous centrally acting drugs in dopamine-radioreceptor assay were different from those in spiroperidol-radioreceptor assay. … Manganese enhanced the specific binding of [3H]-dopamine dramatically by 300% even at low concentrations, although manganese did not influence the specific binding of [3H]-spiroperidol. …
NAID 120002306195